Tritium labeling reaction device

Abstract

The invention belongs to a preparation technology of tritium labeled compounds, and in particular relates to a tritium labeling reaction device. Reaction flasks, three uranium powder bottles and a vacuum pump are connected into a closed system through metal pipes and valves, and are connected to a main pipeline formed by the metal pipes, wherein the three uranium powder bottles are a tritium storage uranium powder bottle, a tritium recovery uranium powder bottle and a spare uranium powder bottle respectively, are arranged in parallel, are connected with the main pipeline, and are provided with a control valve respectively; a surge flask and a cold trap are arranged on the metal pipe, connected with the vacuum pump, of the main pipeline. The device is completely connected through components such as the metal pipes and the vales in clamping and sleeving ways, so that the vacuum tightness of the system is ensured, and the tritium labeling efficiency, stability and safety are improved.

Description

technical field [0001] The invention belongs to the preparation technology of tritium-labeled compounds, in particular to a tritium-labeled reaction device. Background technique [0002] Tritium-labeled compounds have many advantages such as low toxicity, high specific activity, easy synthesis, and superior autoradiography properties. They are ideal tracers and have been widely used in various fields of industry, agriculture, medicine, and scientific research. . Especially in recent years, tritium-labeled compounds have played an increasingly important role in the development of new drugs. In the process of new drug development, pharmacokinetic and pharmacological research is an essential research content for new drug applications. The application of tritium-labeled Compound pharmacokinetics and pharmacology research is an important research method at present. Tritium-labeled compounds play a vital role in the study of the absorption, distribution, metabolism and excretion...

AI Technical Summary

Problems solved by technology

[0004] 1) Easily damaged: due to the fragile glass, once the system is damaged during the tritium marking process, tritium leakage will occur, causing safety accidents

[0005] 2) Poor system stability: Since the glass valve needs to be coated with vacuum grease to strengthen the seal, it is easy to reduce the sealing performance of the system due to the damage of the vacuum grease coating during frequent switching, and cannot maintain a good sealing performance for a long time

[0006] 3) The vacuum degree of the system is poor: the vacuum degree of the system is difficult to reach the order of 10-1Pa, which affects the tritium marking time

[0007] 4) The pressure of the system is low: the glass system cannot withstand high positive pressure. Once the abnormal situation of excessive pressure occurs during the operation of tritium gas, serious accidents such as valve collapse are prone to occur

[0008] 5) The system is greatly affected by temperature: when the room temperature is low in winter, the vacuum degree of the system is difficult to meet the requirements due to the increase in the viscosity of the vacuum grease applied to the valve and the decrease in lubricity

In order to protect the safety of the environment, staff and the public, and reduce the risk of tritium leakage to the lowest possible level, the glass vacuum system device can no longer meet the requirements of tritium labeling reaction

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