The invention discloses a knife rest for a multi-wire cutting machine and the multi-wire cutting machine with the same. The knife rest is divided into a knife rest lower body and a knife rest upper body, the knife rest lower body and the knife rest upper body are rotationally connected through a shaft assembly, the shaft body assembly includes a shaft body and a shaft seat assembly, the shaft bodyis rotationally connected with the shaft seat assembly, the shaft body sequentially comprises a lower shaft body, an upper shaft body, a top fixing disc and a pulling head which are coaxial from bottom to top, and the shaft seat assembly comprises a bearing seat, a bearing, an oil seal cover, an oil seal and an end cover. The multi-wire cutting machine includes the above knife rest. According tothe requirement for slicing sheets with different thicknesses, in particular to the requirement for slicing sheets with large thicknesses, the spacing between steel wires is adjusted, the adjusted steel wires are reliably wound in wire troughs, scraping with wire trough walls is not prone to happening, moving to other wire troughs is not prone to happening, accurate cutting is achieved, the cutting precision and efficiency are greatly improved, and the service life of an upper winding main shaft, a lower winding main shaft and the steel wires is prolonged.