Florfenicol nanoemulsion and preparation method thereof

Abstract

The invention belongs to the field of medicine and pharmacy, and relates to a florfenicol nanoemulsion and a preparation method thereof. The florfenicol nano-emulsion has the prominent advantages that the grain diameter of the emulsion is smaller than 220nm, sterilization can be performed in production by a filter membrane sterilization mode, the production cost can be reduced, and the market competitiveness of the product can be strengthened; N-methyl-2-pyrrolidone, dimethylformamide, dimethyl sulfoxide and other organic solutions with high toxicity are not used as a solvent, so that the safety is high; the product is stable, and has a good water solubility; the nanoemulsion has a long-acting sustained-release effect, the dosage can be reduced, and residues of the nanoemulsion in an organism can be reduced, so that the curative effect can be improved.

Description

technical field [0001] The invention belongs to the field of pharmacy and pharmacy, and relates to a nanoemulsion containing florfenicol and a preparation method thereof. Background technique [0002] Although antibacterial drugs play a vital role in the control and treatment of some infectious diseases, due to the abuse of antibacterial drugs, the resistance of bacteria continues to increase, reducing the efficacy of antibacterial drugs, especially in the field of edible poultry. , bringing great hidden dangers to the health of the people. [0003] Florfenicol (florfenicol, florfenicol) is a synthetic thiamphenicol monofluoride derivative, the third generation of chloramphenicol broad-spectrum antibiotics successfully developed by Schering-Plough in the United States, and it is exclusively for animals. Because the para-nitro group on the aromatic ring of chloramphenicol can cause adverse effects such as aplastic anemia and immunosuppression in animals, it has been banned i...

AI Technical Summary

Problems solved by technology

The existence of organic solutions increases the irritation of drugs to animals, and also brings major hidden dangers to food safety

Guo Kuan prepared florfenicol suspension injection by high-pressure homogenization method, but the particle size is 1.83 microns. According to the requirements of veterinary drug GMP, the injection needs to be produced in a sterile environment, and the particle size is too large to pass through the 0.22 micron membrane method. Sterilization, on the other hand florfenicol is sensitive to heat, which limits the production of florfenicol suspension injection under aseptic conditions throughout the process, which increases the production cost burden (Guo Kuan, Jin Qianyue, Jiang Shanxiang et al., "Shanghai Animal Husbandry and Veterinary Newsletter", Issue 5, 2009: 7-9)