Extract of total flavonoids of coromandel coast falsemallow as well as preparation method and application of extract

A technology for total flavonoids and extracts, applied in the field of Sai Kui extract, can solve the problem of no relevant literature reports on the active components or effective parts of Sai Kui, and achieve the effects of simple and feasible extraction process, stable quality and clear efficacy.

Active Publication Date: 2014-06-04
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no relevant literature report on the active ingredients or effective parts in saguaro

Method used

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  • Extract of total flavonoids of coromandel coast falsemallow as well as preparation method and application of extract
  • Extract of total flavonoids of coromandel coast falsemallow as well as preparation method and application of extract
  • Extract of total flavonoids of coromandel coast falsemallow as well as preparation method and application of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 saguaro extract (reflux extraction method)

[0023] Weigh 20g of Sai Kui, add 200ml of 70% ethanol to soak for 30min, then heat and reflux on a water bath to extract twice. Each time for 1h, filter while hot, wash the residue 2-3 times, combine the filtrate and recover until there is no alcohol smell, add water Dissolve until each 1mL contains 0.5g crude drug, centrifuge (4000r / min) for 15min, filter, and set aside. Take 1.0mL and put it in a 25mL measuring bottle, add 6.0mL of water; add 1.0mL of 5% (mass fraction) sodium nitrite solution, mix well, and let stand for 6min; add 10% (mass fraction) aluminum nitrate 1.0mL, shake well , placed for 6min; then add 10.0mL of 4% (mass fraction) NaOH solution, add water to the mark, shake well, and place for 15min; measure the absorbance A at a wavelength of 500nm according to spectrophotometry (Appendix VB of Chinese Pharmacopoeia 2010 Edition) . The extraction rate of total flavonoids in the ...

Embodiment 2

[0024] The preparation of embodiment 2 saguaro extract (Soxhlet extraction method)

[0025] Weigh 5g of Saikui, add 50ml of 70% ethanol to soak for 30min, control the temperature at 85°C, extract for 4h, and suction filter while it is hot. The residue was washed 2 to 3 times with the corresponding solvent, and the combined filtrate was recovered until there was no alcohol smell, dissolved in water to contain 0.5g crude drug per 1 mL, centrifuged (4000r / min) for 15min, filtered, and set aside. Determination of total flavonoids by the above-mentioned spectrophotometric method, the total extract quality of Sai Kui extracted by this method is about 0.9g, the content of total flavonoids is 0.140g in terms of rutin, accounting for 16% of the total extract, and the extraction rate of total flavonoids is 2.79% %.

Embodiment 3

[0026] Preparation of Example 3 Saikui Extract (Ultrasonic Extraction Method)

[0027] Weigh 20g of Saikui, add 200ml of 70% ethanol to soak for 30min, extract with ultrasonic (300W) twice, 30min each time, and filter while hot. The residue was washed 2 to 3 times with the corresponding solvent, and the combined filtrate was recovered until there was no alcohol smell, dissolved in water to contain 0.5g crude drug per 1 mL, centrifuged (4000r / min) for 15min, filtered, and set aside. Determination of total flavonoids by the above-mentioned spectrophotometric method, the total flavonoids quality extracted by this method is about 3.5g, the content of total flavonoids is 0.716g in terms of rutin, accounting for 20% of the total extract, and the extraction rate of total flavonoids is 3.58 %.

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Abstract

The invention provides an extract of total flavonoids of coromandel coast falsemallow. The weight percent content of the total flavonoids is no less than 1% by taking the weight percent of rutin as a reference. The invention further provides a preparation method and an application of the extract. The extract is stable and controllable in quality as well as simple and feasible in extraction process and cannot perform pollution on the environment, thereby being suitable for large-scale extraction. The extract is used for treating prostatic diseases, and particularly has definite and safe medicinal effects for treating prostatic hyperplasia, prostatitis, prostatic cancers and abacterial prostatitis, thereby providing a new medicine selection for clinical applications.

Description

technical field [0001] The invention relates to a saguaro extract, which belongs to the field of medicine. Background technique [0002] Malvastrum coromandelianum (L.) Garcke is a subshrub plant of Malvaceae, also known as yellow flower grass or yellow cotton. It is a perennial mallow herb, native to the Americas, and now widely distributed in tropical regions of the world. my country is mainly distributed in Taiwan, Fujian, Guangdong, Hong Kong, Hainan, Guangxi, and Yunnan. Saikui is used as medicine with the whole herb, which is bitter, light and cool in nature. It has the effects of clearing away heat and promoting dampness, detoxifying and dissipating blood stasis. Indications for damp-heat diarrhea, jaundice, lung-heat cough, sore throat, hemorrhoids, carbuncle sores, bruises, prostatitis. It is commonly used to treat jaundice hepatitis among the people, and pharmacological experiments have reported that Saikui has antipyretic, analgesic and anti-inflammatory effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P13/08A61P35/00
Inventor 徐伟洪振丰
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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