Method of separating chiral drug penicillamine enantiomer based on functional gold nanochannel

A gold nanochannel and chiral drug technology, which is applied in the field of materials and nanometers, can solve problems such as limitations, time-consuming, and complex detection, and achieve the effects of simple device, easy operation, and good application prospects

Inactive Publication Date: 2014-06-25
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present in this patented technology improves upon how certain chemical compounds are separated by modifying them with an amino group that can be attached at one end or both ends. This results in strong interactions between these molecules which makes it difficult for other substances from entering into their structure without being detected.

Problems solved by technology

Technologies related to this patented technical problem addressed by this patents involve developing an efficient way to separate specific types of small particles called cholesterols from other substances like proteins through nanoporous channels made up of metal atom pairs connected together. These techniques allow scientists to study various aspects such as drug discovery, environmental pollution control, medical diagnosis, etc., providing valuable insights into their origins and potential uses within medicine fields.

Method used

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  • Method of separating chiral drug penicillamine enantiomer based on functional gold nanochannel
  • Method of separating chiral drug penicillamine enantiomer based on functional gold nanochannel
  • Method of separating chiral drug penicillamine enantiomer based on functional gold nanochannel

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Embodiment

[0023] (1) Preparation of gold nanochannel membrane

[0024] Gold was deposited on a polycarbonate film with an inner diameter of 50 nm by chemical deposition. The specific process is as follows: immerse the polycarbonate membrane in anhydrous methanol and oscillate ultrasonically for 5 minutes to wash away the impurities adsorbed on the base membrane and activate the membrane; the cleaned polycarbonate membrane is immersed in SnCl 2 solution for 45min, and constantly shake the solution slightly during the soaking process to make the Sn 2＋ Uniformly adsorbed on the surface of basement membrane and membrane pores; 2 The film was immersed in Ag(NH 3 ) 2 ＋ In the solution for 10min, wash 3 times with methanol, then wash 3 times with water, the immersion concentration is 7.9×10 －3 mol / L gold plating solution (pH=10.0). Gold-plated at 4°C, removed and washed 3 times with water, and washed with 25% HNO 3 Soak for 12 hours, and finally blow dry or air dry to get Au nanochannel...

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Abstract

The invention discloses a method of separating chiral drug penicillamine enantiomer based on a functional gold nanochannel. The method comprises the steps of by taking a polycarbonate (PC) film as a template, adopting a chemical deposition method to prepare a gold (Au) nanochannel film, and modifying L-cysteine (L-Cys) in the Au nanochannel by utilizing action of an Au-S bond to obtain the nanochannel with chiral site selectivity. The modifier L-cysteine has selective adsorption effect on D- penicillamine (D-Pen), but has repulsive action on L-penicillamine (L-Pen); in mixed liquor containing D-pen and L-Pen, the L-penicillamine can preferably passes through the nanochannel which is modified with the L- cysteine, so that complete separation of the penicillamine enantiomer is realized by utilizing the property. The method disclosed by the invention can be used for separating the penicillamine enantiomer, adopts a simple device, is simple to operate and easy to implement, and has better application prospect.

Description

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Claims

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Application Information

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Owner SHANGHAI NORMAL UNIVERSITY
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