Preparation method of palladium-carbon catalyst for synthesizing meropenem

Abstract

The invention discloses a preparation method of a palladium-carbon catalyst for synthesizing meropenem. The preparation method comprises the following steps: (1) putting wood charcoal into a boiling alkali compound water solution, carrying out backflow treatment, washing by virtue of pure water, and drying to obtain an active carbon carrier; (2) preparing an active ingredient solution, and regulating the pH value of the active ingredient solution; (3) pulping the active carbon carrier, and stabilizing the active carbon carrier at a stirring condition, so as to obtain active carbon slurry; (4) adding the active ingredient solution into the active carbon slurry after the pH value of the active ingredient solution is regulated, and stirring to obtain a catalyst precursor; and (5) aging the catalyst precursor, and reducing the catalyst precursor by virtue of a reducing agent, so as to obtain a catalyst finished product. According the preparation method, a low-content alkali compound is utilized for processing the carrier so as to obtain a proper carrier with a reasonable surface chemical structure, so that the consumption of a reagent is reduced; chelated palladium ions of a certain size are prepared by regulating the pH value of the active component solution, so that purposes of controlling the activity and selectivity of the catalyst are realized; the preparation method has no special control point, is simple in process and is beneficial to the industrial large scale production.

Description

technical field [0001] The invention belongs to the technical field of catalyst preparation, and in particular relates to a preparation method of a palladium-carbon catalyst used for the synthesis of meropenem. Background technique [0002] Carbapenem antibiotics mainly include meropenem, imipenem, panipenem, biapenem, ertapenem, faropenem, doripenem, etc. Among them, meropenem has the largest market demand and the most widely used widely. In the last step of its chemical synthesis, it is necessary to use palladium carbon catalyst for hydrogenolysis reaction, as shown in the following reaction formula, while removing the protecting groups PNB (p-nitrobenzyl) and PNZ (p-nitrobenzyloxycarbonyl) ), the palladium-carbon specification used to produce this product on the market is generally 5% to 7% palladium-carbon, and the catalyst charging amount is generally about 20% of the substrate quality, and the product yield is about 48%. The amount of palladium carbon catalyst used i...

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Problems solved by technology

[0007] At present, the yield of the existing system is generally about 49%. Because of the adsorption effect of palladium carbon itself, selectivity, and the dissolution of mixed solvents, it is very difficult to increase the yield of the target product; The price is 20,000 / Kg, every increase of 1 percentage point can increase the net profit by 200 yuan, the performance of the catalyst is directly related to the production cost and competitiveness of the product

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