128results about How to "Conducive to industrial scale-up production" patented technology

The invention discloses a low-density deketoxime type silicone sealant. The sealant comprises components in parts by weight as follows: 100 parts of alpha, omega-dyhydroxyl polydimethylsiloxane, 1-40 parts of dimethyl silicone oil, 0.1-4 parts of thermal expansion microcapsules, 1-25 parts of a cross-linking agent, 20-180 parts of reinforcing filler, 0.01-5 parts of a coupling agent and 0.005-1 part of a catalyst. The invention further discloses a preparation method of the low-density deketoxime type silicone sealant. The low-density deketoxime type silicone sealant has excellent mechanical property and adhesive property, the density of the sealant is remarkably reduced, the foaming effect is excellent, and the stability is high. According to the preparation method, a process is simple and easy to implement, equipment is conventional, operation is facilitated, and industrial large-scale production is facilitated.

The invention discloses an S@NPC / CNT composite material and a preparation method and application thereof. The S@NPC / CNT composite material is obtained from an NPC / CNT composite material by sulfur loading. The NPC / CNT composite material is composed of nitrogen doped porous carbon and carbon nanotubes in the interweaving mode. The nitrogen doped porous carbon is a carbon material derived from a Zn / Co-bimetallic organic framework. The nitrogen doped carbon material is obtained by stirring, drying, calcining and acid treatment of a methyl alcohol and water mixed solution containing zinc and / or cobalt transition metal salt, organic ligand and a carbon material, and finally the high sulfur loaded S@NPC / CNT composite material is prepared by a melt diffusion method. The material exhibits extremelyhigh sulfur content. In addition, the invention also discloses the application of the high sulfur loaded nitrogen doped carbon material prepared by the method in a lithium sulfur battery. The composite material is used for an anode material of the lithium sulfur battery. The obtained battery has high area capacity and good electrochemical performance. The efficient method for preparing the nitrogen doped carbon material with high performance and high sulfur content is provided.

The invention discloses a support catalyst with active metals in atomic-scale dispersion in a carrier. The support catalyst comprises active metal species and carrier metal oxides, wherein active metals comprise one or more of Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, Ru, Rh, Pd, Ag, W, Ir, Pt and Au; and the carrier metals comprise one or more of Ti, Zr, Nb, Ce, Al, Ga, In, Si, Ge and Sn. The invention furthermore discloses a preparation method and application of the catalyst. By virtue of an in-situ carrier generation method, the support catalyst with the active metals in atomic-scale dispersion in the carrier is prepared, and the catalyst is free of aggregate particles of which the granularity is greater than 1nm, of the active metal species. The supportcatalyst is low in raw material cost, simple in reaction operation and high in safety, no after-treatment step is needed, and industrial enlarged production is facilitated. Meanwhile, the application range of the catalyst is wide, and scientific researches and enlarged production for different catalytic systems are facilitated.

The invention discloses a preparation method of nitrogen-containing phosphaphenanthrene derivative flame retardant. The preparation method includes the following steps that 1, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide is added to a reaction kettle, and heating is performed to reach a molten state; 2, triallylisocyanurate and a catalyst are added, full stirring reaction is performed to obtain a coarse product; 3, the coarse product is subjected to washing, filtering and drying to obtain DOPO-TAIC, namely the nitrogen-containing phosphaphenanthrene derivative flame retardant is obtained. The preparation method adopts a melting method to prepare the nitrogen-containing phosphaphenanthrene derivative flame retardant, a reaction principle of the method is consistent to a solvent method, the adopted DOPO is a raw material and is also a solvent in the reaction process, the complicated solvent removing process in the solvent method is omitted, the yields of the same volume of reaction kettles within unit time are greatly increased, the production cost is effectively reduced, harmful organic solvents are not needed, an operation method and production processes are simple, and the method is beneficial to industrialized enlarged production.

The invention provides a novel preparation method of Apalutamide. According to the novel preparation method, 2-fluoro-4-bromo-N-methyl benzene methanamine amide, 1-amino cyclobutyl carboxylate hydrochloride, and the like are taken as initial raw materials, and substitution reaction is carried out so as to obtain 1-((3-fluoro-4-(methyl carbamyl)phenyl)amino) cyclobutane-1-carboxylic acid, wherein synthesis yield is higher than 70%, and purity is higher than 97.2%; then esterification is carried out so as to obtain 1-((3-fluoro-4-(methyl carbamyl)phenyl)amino) cyclobutane-1-carboxylic ester, wherein synthesis yield is higher than 83%, and purity is higher than 97.8%; and at last, ring closing reaction with 2-cyan-3-trifluoromethyl-5-isothiocyano pyridine is carried out so as to obtain Apalutamide, wherein yield is higher than 68%, and purity is higher than 98.1%. The preparation method possesses following advantages: the raw materials are easily available; technology is simple; operationis convenient; yield is high; and cost is low.

The invention discloses a transparent and mildew-proof silane-modified polyether sealant. The transparent and mildew-proof silicone-modified polyether sealant is prepared from the following components in parts by weight: 55 to 80 parts of a basic polymer, 0 to 12 parts of a plasticizer, 8 to 20 parts of filler, 0.3 to 2 parts of a water removing agent, 0 to 1 part of an ultraviolet absorbent, 0 to 1 part of an antioxidant, 0.2 to 2 parts of a catalyst and 0.2 to 5 parts of a coupling agent. The product disclosed by the invention has a transparent appearance, is green and environment-friendly, has good weather resistance, high caking property, no corrosion, good mildew-proof effect and no toxin and harms, and is very applicable to occasions with relatively high mildew-proof environment-friendly requirements, including kitchens, bathrooms and the like.

The invention discloses a preparation method of a palladium-carbon catalyst for synthesizing meropenem. The preparation method comprises the following steps: (1) putting wood charcoal into a boiling alkali compound water solution, carrying out backflow treatment, washing by virtue of pure water, and drying to obtain an active carbon carrier; (2) preparing an active ingredient solution, and regulating the pH value of the active ingredient solution; (3) pulping the active carbon carrier, and stabilizing the active carbon carrier at a stirring condition, so as to obtain active carbon slurry; (4) adding the active ingredient solution into the active carbon slurry after the pH value of the active ingredient solution is regulated, and stirring to obtain a catalyst precursor; and (5) aging the catalyst precursor, and reducing the catalyst precursor by virtue of a reducing agent, so as to obtain a catalyst finished product. According the preparation method, a low-content alkali compound is utilized for processing the carrier so as to obtain a proper carrier with a reasonable surface chemical structure, so that the consumption of a reagent is reduced; chelated palladium ions of a certain size are prepared by regulating the pH value of the active component solution, so that purposes of controlling the activity and selectivity of the catalyst are realized; the preparation method has no special control point, is simple in process and is beneficial to the industrial large scale production.

The invention provides a preparation method of 3-(methyl alkoxy phosphoryl) propionic acid ester compound (I). Methyl ferro phosphoric acid dialkyl ester (III) and acrylic acid (II) are taken as raw materials to react under anhydrous and anaerobic conditions at 0 DEG C to 30 DEG C; and the reaction process is shown as the formula, wherein, R1 in the formula is equal to R2 and is methyl or ethyl. The product yield of the method can reach 96% and the operation is simple with no generation of three wastes, thus being beneficial to industrial amplifying production.

The invention belongs to the biochemical industry field and discloses a Bacillus subtilis and an application thereof in biocatalytic production of L-lactic acid. The method in biocatalytic production of L-lactic acid by using the Bacillus subtilis (the preservation number is CGMCC No.3242) comprises the steps as follows: taking immobilized cells or flocculated cells of the Bacillus subtilis (the preservation number is CGMCC No.3242) as a biocatalyst, catalyzing substrate lactonitrile to obtain L-lactic acid, dehydrating the reaction solution in a falling film evaporator, distilling and dehydrating by a molecular still to obtain the L-lactic acid with the product purity of over 95% and the product yield of over 90%. The invention has the advantages of simple technique operation, mild reaction condition, high utilization degree of the substrate, low energy consumption, high product purity, safety and environment protection, and wide application potential.

The invention provides a hierarchical pore SAPO-34 molecular sieve synthesis method which is characterized in that an aluminum source, a silicon source, a phosphorus source, an organic template agentand water are mixed and added into a hydrothermal reactor, and in-situ synthesis is performed to form an SAPO-34 molecular sieve with hierarchical pores. According to the hierarchical pore SAPO-34 molecular sieve synthesis method, a hierarchical pore structure can be formed without acid or alkali post-treatment process or addition of other components, raw material cost and subsequent separation steps are reduced, industrial amplifying production is facilitated, substance diffusion and heat conduction in methanol-to-olefin reaction are facilitated by formation of the hierarchical pores, and theservice life of the molecular sieve is greatly prolonged.

The invention discloses a high-temperature-resistant methanation catalyst. The high-temperature-resistant methanation catalyst comprises an active component, a carrier and / or an assistant. Nickel serves as the active component, the carrier is mesoporous nickel aluminate spinel, and the assistant is one or more of oxides of alkaline earth metals magnesium, calcium, strontium and barium. The invention further discloses a preparation method of the high-temperature-resistant methanation catalyst. Soluble nickel salt and soluble salt of the assistant are dissolved in water to form impregnation liquid; the mesoporous nickel aluminate spinel carrier is added to the impregnation liquid for impregnation, then drying and calcination are conducted, and then the high-temperature-resistant methanation catalyst is obtained. The high-temperature-resistant methanation catalyst is used at high temperature, the anti-sintering capacity of active center nickel is high, and activity is stable. The production method is simple, and industrial enlarged production is promoted.

The invention discloses a preparation method of Tirzepatide, and belongs to the technical field of peptide synthesis. According to the method, amino resin is adopted as starting resin, a solid-phase polypeptide synthesis method is adopted for preparation, Tirzepatide peptide resin is obtained by a polypeptide solid-phase synthesis method, then Tirzepatide resin is subjected to acidolysis to obtaina Tirzepatide crude product, and finally, the Tirzepatide crude product is purified to obtain a Tirzepatide pure product. According to the method disclosed by the invention, special protective aminoacids, namely Boc-Tyr (tBu)-Aib-OH and Fmoc-Lys (AEEA-AEEA-gamma Glu (alpha-OtBu)-Eicosanedioicacid (mon-tBu))-OH, Fmoc-Tyr-Ser (pro-me-me)-OH and Fmoc-(Dmb)Gly-OH, are adopted. According to the method, the purity of the crude peptide is improved, the material cost and the purification cost are greatly reduced, and industrial large-scale production is facilitated.

The invention discloses a synthetic method for teduglutide and belongs to the field of polypeptide drug synthesis. The method comprises the following steps of by taking amino acids at 2-3 positions ofa teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 5-6 positions of the teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 22-23 positions of the teduglutide sequence as pseudo-proline-dipeptide, or amino acids at 27-28 positions of the teduglutide sequence as pseudo-proline-dipeptide or amino acids at 29-30 positions of the teduglutide sequence as pseudo-proline-dipeptide, sequentially performing solid-phase synthesis on amino acids at other positions of the teduglutide sequence according to a sequence, synthesizing full-protection teduglutide, and performing cracking precipitation to obtain the teduglutide. The method provided by the invention improves the purity of crude peptide, greatly lowers the material cost and the purification cost and is beneficial to industrial amplification production.

The invention belongs to the technical field of industrial catalysis and provides a method for synthesizing dimethyl carbonate and co-producing ethylene glycol by catalyzing transesterification with a loaded ionic liquid. The supported ionic liquid is based on chlorine-containing resin particles as a carrier, and an ionic liquid in which a hydroxyl anion structural unit and an imidazolium cation structural unit are paired as a catalytic active center, and is supported by a chemical bond to prepare a functionalized supported ionic liquid catalyst. It is used to catalyze the transesterification reaction of ethylene carbonate and methanol to simultaneously synthesize two chemical products of dimethyl carbonate and ethylene glycol. The catalyst preparation process is simple and easy to operate, and the catalyst can be recovered by simple filtration, which is very beneficial to solve the problem of difficult separation of the product and the catalyst. It will have great application potential and market prospect.

The invention provides a method for rapid preparation of sodium hyaluronate from a sodium hyaluronate fermentation broth, and the method comprises the following steps: 1) heating the sodium hyaluronate fermentation broth to 100-121 DEG C, maintaining for 10 to 30 minutes, and then quickly performing plate-frame pressure filtration; 2) diluting the filtrate with purified water of 2-4 times, adding 1%-5% of activated carbon for adsorption for 1-5 hours, performing the plate-frame pressure filtration; 3) adsorbing the filtrate with resin for 1 to 2 hours, proportionally adding 0.4mol / L sodium chloride into the adsorption solution; 4) precipitating the sodium hyaluronate with 2-3 times of ethanol, washing, curing and drying to obtain powdery sodium hyaluronate. The method for extraction and preparation of the sodium hyaluronate has the advantages that: redissolving of a crude product is omitted in the whole extraction process, the extraction time is greatly reduced, and the obtained sodium hyaluronate is high in purity, low in protein content, simple in process, less in preparation time, and conducive to large-scale industrial production.

The invention relates to a novel preparation method of 4-cyclopropyl-1-naphthylamine. The raw materials needed for the preparation method are cheap in price and easy to obtain, the reaction step operation is simple, and the total yield is better than that of the prior art level. Moreover, the nitrification, hydrogenation reduction, Suzuki coupling and other reactions are avoided to use, and thus the production difficulty and production cost is greatly reduced. A relatively economical, efficient, safe and environment-friendly synthetic route is provided for the preparation of 4-cyclopropyl-1-naphthylamine.

The invention discloses HMB-Ca production process method, which comprises the following steps that HMB is dissolved in water; calcium salt is added; stirring, filtering and concentration are performedto obtain an HMB-Ca crude product; the HMB-Ca crude product is added into an alcohol solvent; after stirring, filtering and concentration are performed, an organic solvent is added; stirring and filtering are performed; solid drying is performed to obtain an HMB-Ca product; during the filtering, the hole diameter is 1 to 100 micrometers. The HMB-Ca production process method has the advantages that the production operation and purification filtering conditions of the HMB-Ca product are optimized; the mechanical impurities and the metal ion residues in the HMB-Ca product are effectively reduced; the safety when the HMB-Ca product is used as a health care product and food additive is improved; the process conditions are mild; the operation is easy; the production operation safety degrade isreduced; green and environment-friendly effects are achieved; the industrialization is favorably realized.

The invention belongs to the field of biochemical engineering and discloses bacillus subtilis and application thereof in preparation of niacin by biocatalysis. The niacin is prepared by reacting 3-cyanopyridine serving as a substrate with bacillus subtilis KR2 (CGMCC NO.3242) serving as a biocatalyst at 5 to 35 DEG C and 100 to 300rpm for 15 to 96h, wherein the final yield of the niacin is over 90 percent and the purity of the obtained niacin is over 98 percent. The method of the invention is simple in operation and mild in reaction condition, and is suitable for application in scale industrial production.

The invention discloses a supported imidazole ionic liquid catalyst and a method for synthesizing a 2-amino-3-cyano-4H-pyran compound. Malononitrile, aryl aldehyde and ethyl acetoacetate are used as raw materials, and condensation and Michael addition reactions are carried out under the catalytic action of a KIT-6 supported imidazole ionic liquid to synthesize the 2-amino-3-cyano-4H-pyran compound. The method has the advantages of simple operation, mild reaction conditions, low catalyst consumption and high catalytic efficiency, is clean and environment-friendly, and is a green and environment-friendly preparation method.

The invention discloses a method for synthesizing naphthoquinone sulfonyl chloride and belongs to the technical field of organic synthesis.The method includes the step that naphthoquinone sulfonyl chloride is synthesized by naphthoquinone sulfonic acid and di(trichloromethyl) carbonic ester in an inert solvent under the condition that organic base serves as a catalyst.Naphthoquinone sulfonic acid serves as a raw material, safe and environment-friendly di(trichloromethyl) carbonic ester serves as an acylating chlorination reagent, the organic base is used, naphthoquinone sulfonyl chloride is prepared at moderate temperature under simple and convenient operating conditions, industrial production of the compound is promoted, and the whole reaction process meets the requirements on safety and environment friendliness.The yield of the prepared naphthoquinone sulfonyl chloride product is larger than 80%, and the purity of the prepared naphthoquinone sulfonyl chloride product is larger than 95%.

The invention relates to a spherical heteroatom Ni-SAPO-34 molecular sieve, and a preparation method and an application thereof. The preparation method comprises the following synthesis steps: (1) dissolving nickel nitrate hexahydrate in deionized water, and dropwise adding a chelating agent at room temperature while stirring to obtain a Ni chelate solution A; (2) mixing an aluminum source, a phosphorous source, a silicon source, a template and deionized water, and heating and stirring the obtained mixture to obtain an initial sol B; (3) adding the solution A to the initial sol B, and heating and stirring the solution A and the initial sol B to obtain a sol C; and (4) filling a reaction kettle with the sol C, carrying out a crystallization reaction, filtering and washing a product obtained after the reaction is completed until the product is neutral, and drying, calcining and cooling the neutral product to obtain the spherical heteroatom Ni-SAPO-34 molecular sieve. The spherical heteroatom Ni-SAPO-34 molecular sieve with a high crystallinity is synthesized by a sol-hydrothermal synthesis technology, the pressure drop of an accumulated catalyst bed is effectively reduced, the introduction of metallic nickel provides many active sites for the reaction, and the molecular sieve has an important application in an NH3-SCR reaction. The synthesis method has the advantages of simple steps, and easiness in operation.

The invention discloses a (S)-pantoprazole sodium dihydrate the chemically general name of which is (S)-5-difluoromethoxy-2[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium dihydrate. The invention also discloses a preparation method of the (S)-pantoprazole sodium dihydrate. The preparation method comprises the step of cooperatively salifying and crystallizing at a proper temperature by using dichloromethane as a solvent and an alkaline compound of metal sodium as a salifying reagent, thereby obtaining the (S)-pantoprazole sodium dihydrate. The preparation method is simple to operate and mild in reaction condition; the prepared (S)-pantoprazole sodium dihydrate is good in appearance and color, high in purity and stable in quality when stored at room temperature; and industrial production scale can recur.

The invention relates to medical compounds and organic chemical synthesis, in particular to an avibactam intermediate compound and a preparation method thereof. The preparation method of the avibactamintermediate compound comprises the following steps: (1) carrying out a hydrogenation sulfonation reaction on (2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-formamide; (2) after the reactionin the previous step is completed, carrying out washing once, and adding quaternary ammonium bromide for a reaction; and (3) after the reaction is finished, performing extracting, and then carrying out rotary evaporation and crystallizing. Compared with the prior art, the method of the invention has the advantages that operation is simple, raw materials are easy to obtain, cost is low, the purityof an obtained sulfonic acid quaternary ammonium salt is high, and the purity of avibactam sodium generated by sodium salt exchange of the sulfonic acid quaternary ammonium salt is 99.5T, so the method is suitable for large-scale production.

The present invention relates to a separation method of gaseous mixture in the preparation of chlorinated pyridine compounds. Pyridine and derivatives are used as raw materials and react with a chlorating agent in a reactor to prepare the gaseous products of the category of chlorinated pyridine. Under the condition with nitrogen, the gaseous products directly enter at least two distillation units that are connected orderly to realize online distillation and purification; the distillation units respectively comprise a distillation system that consists of a distillation reactor and a distillation tower. The operating temperature of each distillation unit that is arranged orderly is respectively lower than the boiling point of the collected distillate but higher than the boiling point of the adjacent distillate; the distillation unit that are arranged orderly are respectively used for collecting the corresponding distillates with the boiling points decreasing orderly. The operation is simple; the separation and the reaction can operate simultaneously, thus shortening the total time of the process; the target compound with high content can be prepared at one time. And the separation method has the advantages of low coking rate of the product, less loss, low energy consumption, small occupied space, high utilization rate, high operation safety, and suitability for the industrial production.

The invention discloses a treatment process of VOCs (volatile organic chemicals) waste gas. The treatment process includes the steps: removing water-soluble VOCs; removing water-insoluble VOCs. Two steps adopt at least two serially connected waste gas absorption units. In the same removal step, absorbing agents enter from a tail end waste gas absorption unit, waste gas enters the waste gas absorption unit and contacts with the absorbing agents, one part of generated absorption liquid absorbing the VOCs cycles to the waste gas absorption unit and serves as the absorbing agents to be used, and the rest absorption liquid cycles to the front waste gas absorption unit and serves as absorbing agents of the front waste gas absorption unit to be used. The process has the advantages that the purification efficiency of the VOCs is improved, the consumption of the absorbing agents is reduced, energy consumption is reduced, and the height of an absorption tower is reduced.

The invention discloses a synthesis process of a phosphinate containing alkylaryl in a molecular structure. The phosphinate has the structure as shown in the specification, wherein R1 represents the alkyl of C1-C6, R2 represents hydrogen or the alkyl of C1-C5, and M represents aluminum, zinc, tin (II) or iron; phosphinate is prepared from raw materials aryl phosphorus dichloride and C1-C6 alkanol by virtue of three reactions of esterification, rearrangement and salifying precipitation. Compared with the traditional process in which olefins and phosphinic acid or the metal salts are taken as the raw materials and the synthesis method of free radical addition is adopted, the synthesis process of phosphinate containing alkylaryl in the molecular structure has the advantages that high-pressure reactions are avoided, the operations are simple, the raw materials are richer in source, and the synthesis process is suitable for industrial production.

The invention relates to a synthetic method of beraprost. The synthetic method comprises the following steps: with an intermediate I as an initial raw material, carrying out selective primary alcoholoxidation and a Witting reaction to obtain an intermediate V; carrying out reduction and column chromatography purification on the intermediate V to obtain an intermediate IV; and hydrolyzing the intermediate IV to obtain beraprost. According to the synthetic method disclosed by the invention, two hydroxyl groups of the intermediate I are selectively oxidized, so a hydroxyl protection reagent is prevented from being used; in the oxidation step, ultralow-temperature (-60 to -80 DEG C) reactions and use of a reagent DCC with relatively high toxicity are avoided; in the reduction step, diisobutylaluminum hydride is prevented from being used; process operation units are greatly reduced, reaction steps are shortened, emission of three wastes is reduced, and the reactions are more efficient andenvironment-friendlier; and the main peak content of the prepared beraprost reaches 99.0% or above, and total process yield reaches 26% or above. The invention provides the synthetic method which ismore beneficial for industrial production.

The invention discloses an organic red light micromolecule based on feidazole-trans-diphenyl dicyanide ethylene and a preparation method and application thereof in an electroluminescent device, and belongs to the technical field of organic electroluminescence. Beginning from phenanthrenequinone, a one-pot method is adopted for preparing feidazole raw materials, feidazole and trans-diphenyl dicyanide ethylene are connected through a Suzuki condensation reaction to obtain a novel feidazole derivative of the D-pi-A-pi-D structure adopting feidazole as a donor and adopting the trans-diphenyl dicyanide ethylene as a receptor. The obtained compound has the high fluorescence quantum yield and can be adopted as a luminous layer to be applied in a non-doped or doped organic light-emitting device (OLED), and the prepared device has the advantages of being high in efficiency, low in driving voltage and the like.

The invention relates to the field of catalysts, and discloses a lanthanum oxycarbonate catalyst as well as a preparation method and application thereof. The lanthanum oxycarbonate catalyst is of a rod-like nano structure. The preparation method of the lanthanum oxycarbonate catalyst comprises the following steps of: performing a hydrothermal reaction on a mixed solution of a lanthanum-containing compound, optional alcohol and water under an alkaline condition, and then sequentially drying and roasting a solid material obtained after the hydrothermal reaction to obtain the lanthanum oxycarbonate catalyst. The lanthanum oxycarbonate catalyst provided by the invention can be used for efficiently carrying out methane oxidative coupling reaction at a relatively low temperature.