Folic acid-nano-TiO2 composite photocatalyst and its preparation method and use

A catalyst and composite light technology, applied in chemical instruments and methods, organic compound/hydride/coordination complex catalysts, physical/chemical process catalysts, etc., can solve toxic and side effects, easy recurrence, and difficult to completely eradicate with surgical therapy and other problems, to achieve the effects of strong targeting, cheap reagents, and improved photocatalytic efficiency

Inactive Publication Date: 2014-07-09
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Cancer is a serious threat to human health. In recent years, the incidence and mortality of cancer have remained high. However, traditional cancer treatment methods such as radiotherapy and chemotherapy have serious toxic and side effects on the human body; and surgical treatment is often difficult. Completely eradicated, and easy to relapse after treatment

Method used

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  • Folic acid-nano-TiO2 composite photocatalyst and its preparation method and use
  • Folic acid-nano-TiO2 composite photocatalyst and its preparation method and use
  • Folic acid-nano-TiO2 composite photocatalyst and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] TiO 2 / SiO 2 preparation of

[0032] 0.5g nano-TiO 2 , 10ml of deionized water, and ultrasonically oscillate for 20 minutes. Add 0.5% Na(PO 3 ) 6 solution and sonicated aqueous tetraethyl silicate (TEOS) with controlled mass percent SiO 2 / TiO 2=1 / 5, add ammonia water with a concentration of 25% as a catalyst, and stir for 4h. Then 2ml of ethanol was added, and the slurry was filtered, washed, dried, and ground to obtain SiO 2 Coated Nano TiO 2 Powder.

[0033] TiO 2 / SiO 2 -NH 2 preparation of

[0034] (1) Weigh 0.1g nano-TiO 2 / SiO 2 The complex was dissolved in distilled water in a 150ml round-bottomed flask, and an excess of 3-aminopropyltriethoxysilane was added, sonicated at 40kHz for 10min, heated to 60°C under nitrogen protection, and reacted for 6h in a water bath with constant stirring , cooled to room temperature after the reaction,

[0035] (2) Suction filter the product generated in step (1), and wash repeatedly with ...

Embodiment 2

[0042] TiO 2 / SiO 2 The preparation is with embodiment 1.

[0043] TiO 2 / SiO 2 -NH 2 preparation of

[0044] (1) Weigh 0.1g nano-TiO 2 / SiO 2 The complex was dissolved in distilled water in a 150ml round-bottomed flask, and excess 3-aminopropyltriethoxysilane was added, sonicated at 40kHz for 20min, heated to 100°C under nitrogen protection, and reacted for 24h in a water bath with constant stirring , cooled to room temperature after the reaction,

[0045] (2) Suction filter the product generated in step (1), and wash repeatedly with DMSO to remove unreacted 3-aminopropyltriethoxysilane,

[0046] (3) The product of step (2) was vacuum-dried at 100°C for 12 hours to obtain nano-titanium dioxide (TiO2) with amino groups attached to the surface. 2 / SiO 2 -NH 2 );

[0047] FA-CONH-TiO 2 / SiO 2 Preparation of complex

[0048] (4) Dissolve 0.093g of dicyclohexylcarbodiimide (DCC) and 0.077g of N-hydroxysuccinimide (NHS) in 27ml of DM...

Embodiment 3

[0052] TiO 2 / SiO 2 The preparation is with embodiment 1.

[0053] TiO 2 / SiO 2 -NH 2 preparation of

[0054] (1) Weigh 0.1g nano-TiO 2 / SiO 2 The complex was dissolved in distilled water in a 150ml round-bottomed flask, and excess 3-aminopropyltriethoxysilane was added, sonicated at 40kHz for 15min, heated to 80°C under nitrogen protection, and reacted for 15h in a water bath with constant stirring , cooled to room temperature after the reaction,

[0055] (2) Suction filter the product generated in step (1), and wash repeatedly with DMSO to remove unreacted 3-aminopropyltriethoxysilane,

[0056] (3) The product of step (2) was vacuum-dried at 70°C for 12 hours to obtain nano-titanium dioxide (TiO2) with amino groups attached to the surface. 2 / SiO 2 -NH 2 );

[0057] FA-CONH-TiO 2 / SiO 2 Preparation of complex

[0058] (4) Dissolve 0.093g of dicyclohexylcarbodiimide (DCC) and 0.077g of N-hydroxysuccinimide (NHS) in 27ml of DMF ...

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Abstract

The invention relates to a folic acid-nano-TiO2 composite photocatalyst. The folic acid-nano-TiO2 composite photocatalyst comprises TiO2/SiO2 nanoparticles of which the surfaces are modified by folic acid and has a structural formula of FA-CONH-TiO2/SiO2. Through amination coupling of a nano-TiO2/SiO2 composite material and folic acid, compound stability and targeting properties are improved. Nano-TiO2 surfaces are coated with SiO2 so that nano-TiO2 photocatalytic efficiency is improved, nano-TiO2 thermostability is improved and agglomeration caused by nano-TiO2 surface properties is avoided. The folic acid-nano-TiO2 composite photocatalyst can be used for photocatalysis killing of cancer cells and has high killing efficiency and strong targeting properties.

Description

technical field [0001] The invention belongs to the field of new materials and their preparation, in particular, relates to a folic acid targeted amination nano-TiO 2 / SiO 2 Composite photocatalyst, preparation method and application. Background technique [0002] TiO 2 Photocatalytic killing of cancer cells is a new method of cancer treatment under exploration. The principle is that ultraviolet light excites TiO 2 Formation of photogenerated holes (h + ) - electron (e - ) right. Under the action of the space electric field, holes and electrons can be separated, and react with water and dissolved oxygen to generate OHH 2 o 2 、HO 2 (Reactive oxygen species, ROS) components. These active oxygen components react with biomacromolecules, destroying biological structures directly or through a series of peroxidative chain reactions, thereby killing cancer cells. [0003] Due to nano TiO 2 It has the advantages of good band gap, strong photocatalytic ability, non-toxic, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/38A61K41/00A61K9/14A61P35/00
Inventor 张爱平王娟仝月菊韩冬付正卿
Owner SHANXI MEDICAL UNIV
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