Use of plasma treated silicone oil as a coating in a medical injection device
A technology of injection device and plasma, applied in the direction of coating, syringe, medical packaging, etc., can solve the problem of unresolved particles
Inactive Publication Date: 2014-07-30
BECTON DICKINSON FRANCE
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- Abstract
- Description
- Claims
- Application Information
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[0042] However, this document does not address the aforementioned particle problem
Method used
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[0113] refer to figure 1 , the injection device comprises a container (such as a barrel 2) and a bung 3 slidingly engaged within the barrel 2.
[0114] The container 2 of the injection device may be made of any kind of glass or plastic suitable for medical applications.
[0115] The plug 3 can be made of any elastomeric material (eg rubber, butyl rubber, silicone rubber).
[0116] The container 2 and / or the stopper 3 may be laminated with any suitable coating, such as hydrophilic coatings, hydrophobic coatings and fluorinated coatings.
[0117] For example, the stopper 3 may be adapted to be connected to the plunger rod of a syringe or syringe pump.
[0118] For this purpose, it comprises any suitable connection means, such as a threaded portion 31 or the like.
[0119] The end 20 of the barrel 2 opposite the bung 3 may be adapted to be connected to a needle 4, cap or catheter, or may comprise a staked needle.
[0120] The inner wall 21 of the cylinder 2 is coated with a lub...
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Abstract
The invention relates to the use of plasma treated silicone oil as a coating in a medical injection device comprising a barrel and a stopper in gliding engagement within the barrel, for limiting the number of particles present on the surface of the coating and for limiting the number of particles released in a pharmaceutical composition contained in the injection device. The invention also relates to a medical injection device having: a barrel having an inner surface; a stopper in gliding engagement with the barrel; and a pharmaceutical composition within the medical injection device and in contact with the inner surface of the barrel, the inner surface of the barrel comprising a coating of plasma treated silicone oil in contact with the composition, wherein the plasma treatment of silicone oil reduces the number of particles present on the surface of the coating and the number of particles released into the pharmaceutical composition contained in the medical injection device as compared to silicone oil that is not plasma treated. The invention further relates to a method of treating a medical injection device, the device comprising a barrel having a coated inner surface, a stopper in gliding engagement with the barrel, and to a method of reducing a number of particles present on a surface of a coating or a number of particles released into a pharmaceutical composition contained in such a medical injection device.
Description
technical field [0001] The present invention relates to the use of a layer of plasma treated silicone oil as a coating for a medical injection device comprising a barrel and a stopper with a gliding engagement within said barrel , the silicone oil is used to limit the number of particles released into the pharmaceutical composition contained in the injection device. Background technique [0002] Medical injection devices comprising a sealing bung in sliding engagement within a container are widely used to deliver medicaments to patients by injection. [0003] Such injection devices include syringes, cartridges, but also auto-injectors. [0004] Many different types of injection devices have been designed for administering drugs. Injection devices generally comprise a container intended to contain a product to be injected, and a plunger rod intended to move a stopper within said container to expel the product therefrom upon injection. Empty and prefilled single-use injecti...
Claims
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IPC IPC(8): A61M5/31A61M5/315
CPCA61M2005/3131F04C2270/041A61M5/3129A61J1/05A61L31/14A61M2205/0222A61L2400/10A61L2420/02A61L31/10A61M2005/3117A61L2400/18
Inventor S·让维耶P·曼贾加利S·茹弗雷C·富歇Y·昂富
Owner BECTON DICKINSON FRANCE