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A kind of carrageenan and gelatin microsphere embolic agent and preparation method thereof

A technology of embolic agent and carrageenan, which is applied in the field of medicine to achieve the effects of slow degradation, improved effect, and slow release

Active Publication Date: 2016-03-02
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Embolization microspheres are the first choice in the treatment of some unresectable tumors, and there are no reports on carrageenan red and gelatin microspheres and their preparation processes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of carrageenan-gelatin microsphere embolism by emulsification crosslinking method

[0027] Weigh 60mg PLA and 60μL iodized oil and dissolve in 2mL dichloromethane solution, sonicate in an ice bath for 1min to make the inner oil phase. Weigh 0.6g of gelatin and 0.6g of carrageenan powder, slowly sprinkle the powder in 10mL of pure water, swell at 55°C for 20min, add 0.1g of Tween60 dropwise to make a water phase. Measure 50mL of liquid paraffin, add 0.5g of Span60 dropwise, and preheat at 55°C to make the outer oil phase. Slowly inject the inner oil phase into the water phase, stir at 55°C and 800rpm for 30min, and form O / W colostrum after dichloromethane volatilizes. Add colostrum dropwise to the external oil phase preheated to 55°C, adjust the rotation speed to 500rpm, and continue stirring at 55°C for 15 minutes to form O / W / O type double emulsion. Stir and cool for 30 min, add 1.5 ml of 25% glutaraldehyde solution dropwise, and continue sti...

Embodiment 2

[0028] Example 2: Preparation of carrageenan-gelatin microsphere embolism by emulsification crosslinking method

[0029] Weigh 45mg of PLA and dissolve in 2mL of dichloromethane solution, and ultrasonicate in ice bath for 1min to make the inner oil phase. Weigh 0.9g of gelatin and 0.3g of carrageenan powder, slowly sprinkle the powder in 10mL of pure water, swell at 55°C for 20min, add 0.08g of Tween80 dropwise to make a water phase. Measure 50mL of liquid paraffin, add 0.4g of Span80 dropwise, and preheat at 55°C to make the outer oil phase. Slowly inject the inner oil phase into the water phase, stir at 55°C and 800rpm for 30min, and form O / W colostrum after dichloromethane volatilizes. Add colostrum dropwise to the external oil phase preheated to 55°C, adjust the rotation speed to 500rpm, and continue stirring at 55°C for 15 minutes to form O / W / O type double emulsion. Stir and cool for 30 min, add 1.5 ml of 25% glutaraldehyde solution dropwise, and continue stirring for 1...

Embodiment 3

[0030] Example 3: Preparation of carrageenan-gelatin microsphere embolism by emulsification cross-linking method

[0031]Weigh 50 mg of PLA and dissolve it in 2 mL of dichloromethane solution, and sonicate in an ice bath for 1 min to form an internal oil phase. Weigh 1.0g of gelatin and 0.2g of carrageenan powder, slowly sprinkle the powder in 10mL of pure water, swell at 55°C for 20min, add 0.1g of Tween60 dropwise to make a water phase. Measure 50mL of liquid paraffin, add 0.5g of Span60 dropwise, and preheat at 55°C to make the outer oil phase. Slowly inject the inner oil phase into the water phase, stir at 55°C and 800rpm for 30min, and form O / W colostrum after dichloromethane volatilizes. Add colostrum dropwise to the external oil phase preheated to 55°C, adjust the rotation speed to 500rpm, and continue stirring at 55°C for 15 minutes to form O / W / O type double emulsion. Stir and cool for 30 min, add 1.5 ml of 25% glutaraldehyde solution dropwise, and continue stirring ...

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Abstract

The invention discloses a carrageenan and gelatin microsphere embolization agent and a preparation method thereof. The carrageenan and gelatin microsphere embolization agent comprises mixed glue formed by carrageenan and gelatin, a biodegradable polymer, an emulsifier and a crosslinking agent. The carrageenan and gelatin microsphere embolization agent is a novel microsphere integrated with embolism and medicine administration functions, and can be applied to treatment of diseases such as tumors and the like. By adopting the preparation method of the microsphere, the novel microsphere, which has the advantages of wide grain diameter distribution range, large drug loading capacity, long embolization time, controllable in-vivo degradation time and the like can be prepared. The function of the existing microsphere is perfected, the carrageenan and gelatin microsphere embolization agent is prepared by using an emulsion crosslinking method, the carrageenan and gelatin microsphere embolization agent is simple in process, and convenient to operate, and good news is brought about for a patient.

Description

technical field [0001] The invention relates to a composite microsphere embolic agent and a preparation method thereof, in particular to a composite microsphere embolic agent containing carrageenan gelatin in different proportions and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Transcatheter arterial chemoembolization (transcatheter arterial chemoembolization TACE) was proposed by the Japanese scholar Dr. Yamada in 1977. It was first used in the treatment of liver cancer. Embolization not only blocks the blood supply of the tumor, making the tumor lack the necessary nutrient supply, but also enhances the lethality of the drug to the tumor and reduces the systemic toxicity of the drug. Compared with traditional chemotherapy, it has obvious advantages. The basic principle is that most of the blood supply to liver tumors (95-99%) comes from the hepatic artery, while the normal liver actually has a dual blood supply f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/36A61K9/113A61K9/16A61L31/06
Inventor 熊非刘坤良顾宁高喜乐
Owner SOUTHEAST UNIV
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