Carrageenan and gelatin microsphere embolization agent and preparation method thereof

Abstract

The invention discloses a carrageenan and gelatin microsphere embolization agent and a preparation method thereof. The carrageenan and gelatin microsphere embolization agent comprises mixed glue formed by carrageenan and gelatin, a biodegradable polymer, an emulsifier and a crosslinking agent. The carrageenan and gelatin microsphere embolization agent is a novel microsphere integrated with embolism and medicine administration functions, and can be applied to treatment of diseases such as tumors and the like. By adopting the preparation method of the microsphere, the novel microsphere, which has the advantages of wide grain diameter distribution range, large drug loading capacity, long embolization time, controllable in-vivo degradation time and the like can be prepared. The function of the existing microsphere is perfected, the carrageenan and gelatin microsphere embolization agent is prepared by using an emulsion crosslinking method, the carrageenan and gelatin microsphere embolization agent is simple in process, and convenient to operate, and good news is brought about for a patient.

Description

technical field

[0001] The invention relates to a composite microsphere embolic agent and a preparation method thereof, in particular to a composite microsphere embolic agent containing carrageenan gelatin in different proportions and a preparation method thereof, belonging to the technical field of medicine. Background technique

[0002] Transcatheter arterial chemoembolization (TACE) was proposed by Japanese scholar Dr. Yamada in 1977. It was first applied to the treatment of liver cancer. It refers to perfusing chemotherapy drugs through a catheter inserted into the target artery under X-ray fluoroscopy. Embolization with embolic agents not only blocks the blood supply of the tumor, making the tumor lack the necessary nutrient supply, but also enhances the lethality of the drug to the tumor and reduces the systemic toxicity of the drug, which has obvious advantages over traditional chemotherapy. The basic principle is that most of the blood supply to liver tumors (95-99%)...