Early bladder cancer serum miRNAs specific expression profile and diagnostic model
A technology of specific expression profile and diagnostic model, which is applied in the field of specific expression profile of serum miRNAs in early bladder cancer, which can solve the problems of low sensitivity, difficulty in finding bladder, and limited prediction of bladder cancer staging.
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[0052] 1. Research object
[0053] Serum samples were collected from 175 bladder cancer patients (BC) and 165 controls who excluded urological tumors with the consent of the subjects. All bladder cancer patients were inpatients from the Urology Department of Qilu Hospital of Shandong University (hereinafter referred to as our hospital). They were all patients admitted to the hospital for treatment for the first time. Or postoperative pathological examination confirmed. Controls included 37 patients with benign prostatic hyperplasia, 25 patients with urolithiasis, 19 patients with cystitis and 84 healthy individuals. Among them, urine samples were obtained from 75 patients with bladder cancer, 16 patients with benign prostatic hyperplasia, 13 patients with urinary calculi, 8 patients with cystitis and 38 healthy individuals. All serum and urine samples were obtained before patients received any medical or surgical treatment.
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