Hemoside compounds and application thereof

A technology of hualuoside and its compounds, which are applied in the field of hualuoside compounds and their applications, to achieve the effect of increasing curative effect, significantly multidrug-resistant tumor cells, and sensitizing anticancer drugs to inhibit multidrug-resistant tumor cells

Active Publication Date: 2014-08-27
广州中医药大学热带医学研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The development of new tumor drug synergists with clear structure and excellent curative effect is one of the ideal ways to realize the ideal, but so far there is no example of the development of tumor chemotherapy drug synergists from natural sources into commercial drugs

Method used

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  • Hemoside compounds and application thereof
  • Hemoside compounds and application thereof
  • Hemoside compounds and application thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0023] Hualuoside compound, the structural general formula of described Hualuoside compound is as follows:

[0024]

[0025] In the formula: thick solid line represents β substituent, dotted line represents α substituent, corrugated line represents α substituent or β substituent, Me is methyl; X is hydroxyl or sugar chain; Z is hydrogen or hydroxyl; Y , Y 1 are independently hydrocarbon groups with 0 to 4 carbons; W and W1 are independently aromatic hydrocarbon groups or heterocyclic aromatic hydrocarbon groups.

[0026] Preferably, Y, Y in the general formula of the above-mentioned hualuoside compounds 1 independently contain at most one ethylenic bond; in particular, Y is vinyl.

[0027] Preferably, W and W in the general formula of the above-mentioned hualuoside compounds 1 is independently a phenyl group or a heterocyclic aromatic hydrocarbon group in which one C atom is replaced by a N, O or S atom.

[0028] Preferably, the sugar chains in the general formula of th...

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Abstract

The invention discloses hemoside compounds and an application thereof. The structure general formula of the hemoside compounds are as shown in the description, wherein the heavy solid line represents a beta substituent group, the dash line represents an alpha substituent group, the wavy line represents an alpha substituent group or a beta substituent group, and Me is a methyl; X is a hydroxyl or a carbohydrate chain; Z is hydrogen or a hydroxyl; Y and Y1 are independently alkyls with 0-4 carbon atoms; and W and W1 are independently aryl groups or heterocyclic aryl groups. The compounds claimed in the invention have significant effect on enhancing sensitization of anticancer drugs for inhibiting tumor cells with multidrug resistance, and provide new chemotherapeutic sensitizer selection for tumor chemotherapy. These compounds, which are used as active components, can be used alone, or can be used with anti-tumor chemotherapeutic drugs to realize combined action, and thus to reach the purpose of improving efficacy of anti-tumor chemotherapeutic drugs.

Description

technical field [0001] The present invention relates to a compound and its application, in particular to a hualuoside compound and its application. Background technique [0002] Chemotherapeutic drugs play an important role in the treatment of malignant tumors, but the problems of toxic side effects and drug resistance arising from the chemical structure of tumor chemotherapeutic drugs are difficult to solve. On the one hand, most chemotherapeutic drugs have different degrees of toxic and side effects, and they also have different degrees of killing effects on normal human cells while inhibiting tumors; on the other hand, the drug resistance of tumor cells to drugs is acquired. It is a huge obstacle to the ideal curative effect. The main reason for the failure of chemotherapy for malignant tumors is the drug resistance that exists in the tumor cells themselves or produced during chemotherapy. In the use and research and development of tumor drugs, "enhancing efficiency and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J43/00A61K31/706A61K31/58A61P35/00
Inventor 胡英杰吴斯东沈小玲符林春
Owner 广州中医药大学热带医学研究所
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