Peritoneal dialysate containing gsk-3 inhibitors

A technology of peritoneal dialysis fluid and peritoneum, which is applied in the field of peritoneal dialysis fluid, and can solve problems such as weakening cellular defense mechanisms

Active Publication Date: 2019-05-03
ZYTOPROTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Interestingly, however, incubation with standard glucose-based PD solution resulted in the downregulation of HSP expression in mesothelial cells, resulting in weakened cellular defense mechanisms

Method used

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  • Peritoneal dialysate containing gsk-3 inhibitors
  • Peritoneal dialysate containing gsk-3 inhibitors
  • Peritoneal dialysate containing gsk-3 inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0050] method

[0051] cell culture

[0052] The human Met-5a cell line was purchased from the American Type Culture Collection (ATCC, Rockville, MD). All the cells were cultured in the M199 medium supplemented with L-glutamine (0.1 gram / liter), penicillin (100 U / ml), streptomycin (100 μg / ml), 10% fetal bovine serum (FBS), and at 37°C with 5% CO 2 Breed in humid air in an incubator. Unless otherwise stated, standard chemicals were purchased from Sigma-Aldrich (St. Louis, MO, USA). Falcon TM Tissue culture plastic (Becton Dickinson Company, Franklin Lakes, NJ, USA) was used for all cell culture procedures.

[0053] PDF exposed

[0054] For culturing with PDF, glucose-based low pH (5.5) 3.86% fluid (peritoneal dialysate PD4 solution), icodextrin-based low pH (5.5) fluid (polysaccharide dialysate); from BAXTER AG, Vienna, Austria Amino acid-based fluid (pH 6.7) (amino acid dialysis fluid) and glucose-based neutral pH lactic acid / bicarbonate buffer (physiological dual-chamb...

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Abstract

The present invention relates to a peritoneal dialysis solution comprising a compound that inhibits the activity of glycogen synthase kinase (GSK)-3, in particular (GSK)-3β, for the prevention of infectious and non-infectious Peritoneal complications such as peritonitis, peritoneal injury, damage and failure, barrier dysfunction and mesothelial cell shedding.

Description

technical field [0001] The present invention relates to a peritoneal dialysis solution (hereinafter also referred to as "PDF"). Background technique [0002] Compared with hemodialysis, peritoneal dialysis (PD) is a safe, cost-effective renal replacement therapy that provides better quality of life. However, peritoneal dialysis treatment often results in a progressive decline in the ultrafiltration function of the membrane, often associated with peritoneal tissue changes and loss of peritoneal integrity (1). [0003] Currently, more than two-thirds of patients suffer from PD-related infectious or non-infectious complications (such as peritonitis, degeneration of peritoneal function, or technical deficits) during the first two years of their treatment. [0004] Different kinds of fluids are available for PD. The difference between these fluids is the type of osmotic agent, its concentration and the type of buffer and pH value in the PD fluid. [0005] In clinical practice,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/433A61K31/718A61K33/14A61K45/06A61P7/08A61P31/00
CPCA61K45/06A61K31/433A61K31/718A61K33/14A61M1/287A61P31/00A61P39/00A61P43/00A61P7/08A61K2300/00
Inventor 克里斯蒂娜·西拉维亚·鲁绍伊克里斯托弗·奥弗里希特
Owner ZYTOPROTEC
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