Artemisia argyi leaf oil transdermal patch, preparation method and detection method for active ingredients in the patch

A technology of transdermal patch and mugwort leaf oil, which is applied in the field of mugwort leaf oil transdermal patch, can solve the problems of affecting drug efficacy, poor adhesion, cohesion and permeability, and achieve significant dose-dependent anti-inflammatory and The effect of promoting blood circulation and removing blood stasis, high accuracy and excellent effect

Active Publication Date: 2017-08-01
葛月宾 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Artemisia argyi volatile oil (referred to as Artemisia argyi oil) is one of its main active ingredients. It is known that it has pharmacological effects such as antitussive and asthma, liver and gallbladder protection, antibacterial and antiviral, and immune function enhancement. However, at present, Artemisia argyi oil is mainly prepared into soft capsules , dripping pills, nanoemulsions and other dosage forms affect their efficacy. Although there are a small number of transdermal patch dosage forms, the formulas are relatively simple, and their performance in adhesion, cohesion and permeability is not good, and continuous improvement is still needed

Method used

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  • Artemisia argyi leaf oil transdermal patch, preparation method and detection method for active ingredients in the patch
  • Artemisia argyi leaf oil transdermal patch, preparation method and detection method for active ingredients in the patch
  • Artemisia argyi leaf oil transdermal patch, preparation method and detection method for active ingredients in the patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of mugwort leaf oil transdermal patch

[0030] Add 0.4 parts of glyoxate and 0.09 parts of ethylenediaminetetraacetic acid sodium salt into 40 parts of propylene glycol and stir to disperse, then add 8 parts of sodium polyacrylate NP-7000, and stir evenly to form a humectant phase; mix 10 parts of mugwort leaf oil with Tween 4 Mix evenly, then add ultrapure water equal to the volume of mugwort leaf oil to emulsify, add water to dilute to the required amount, add 6 parts of kaolin and 3 parts of gelatin in turn, stir and mix well, as the water phase; slowly add the water phase Stir and mix the humectant phase to obtain a colloid, which is coated on a clean non-woven fabric, covered with a protective film, left to cure for 12 hours, and a mugwort leaf oil transdermal patch is obtained.

Embodiment 2

[0031] Example 2 Preparation and prescription optimization of mugwort leaf oil transdermal patch (single factor investigation test)

[0032] 1. Prescription composition

[0033] The test prescription of this embodiment is divided into 7 groups: basic group: humectant (glycerin), filler (kaolin), patch skeleton (NP-700), cross-linking regulator (EDTA-2Na), cross-linking agent (glycolic acid The matrix weight percent of aluminum), tackifier (PVP-K90), pH regulator (tartaric acid) is 30%: 5%: 5%: 0.05%: 0.3%: 2%: 0.2%.

[0034] Moisturizer (glycerol), filler (kaolin), patch skeleton (NP-700), cross-linking regulator (EDTA-2Na), cross-linking agent (aluminum glycerol), tackifier (PVP-K90) And the matrix content of the pH regulator (tartaric acid) is a variable, and the proportion of the matrix content of other auxiliary materials of the patch is constant, and the prescription matrix sample is prepared.

[0035]2. Preparation process: Disperse the prescribed amount of aluminum gl...

Embodiment 3

[0047] Example 3 Preparation and prescription optimization of mugwort leaf oil transdermal patch (orthogonal test of four factors and three levels)

[0048] (1) See Table 2 for the level table

[0049] Table 2 Factor level table

[0050]

[0051] (2) Prescription composition: Except for the above-mentioned four level factors, other matrix components are based on the basic group in Example 2, and are combined according to Table 3 matrix.

[0052] (3) Preparation process: with embodiment 2.

[0053] (4) Orthogonal experiment result and analysis: see table 3, table 4 and table 5, the result proves, the optimum combination of four factors of this orthogonal experiment is: A 2 B 2 C 2 D. 1 Namely glycerin 30%, NP-7005%, aluminum glycylate 0.3%, EDTA 0.03%. Through single factor experiment and orthogonal experiment, the dosage of excipients for optimal prescription was finally determined to be moisturizing agent glycerin 30%, hydrogel patch skeleton sodium polyacrylate NP-7...

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Abstract

The invention discloses a blumea oil transdermal patch, a preparation method thereof and a method for detecting active components contained in the blumea oil transdermal patch. The blumea oil transdermal patch comprises a back lining material, a medicated layer and a protective film, wherein the medicated layer comprises a humectant, a filling agent, a patch skeleton, a cross-linking regulating agent, a cross-linking agent, a thickening agent, an emulsifying agent and blumea oil. The blumea oil transdermal patch disclosed by the invention has the advantages of high medicine permeability and good adhesion without stimulation. The preparation method of the blumea oil transdermal patch comprises the following steps: respectively preparing a humectant phase composed of the cross-linking agent, the cross-linking regulating agent, the humectant and the patch skeleton and a water phase composed of the blumea oil, the emulsifying agent, ultrapure water, the filling agent and the thickening agent; slowly adding the humectant to the water phase, uniformly stirring and mixing to obtain a colloid, coating the colloid to the back lining material, adhering the protective film, and standing to solidify for 6-12 hours. According to the method for measuring the pharmacological active components contained in the blumea oil transdermal patch, an HP-INNOWAX capillary chromatographic column is adopted, the flowing phase is N2, the flow velocity is 0.7-1 mL.min<-1>, and the content of eucalyptol, camphor and borneol can be accurately measured.

Description

technical field [0001] The invention relates to a mugwort leaf oil transdermal patch, a preparation method and a detection method for active components in the patch. Background technique [0002] Transdermal drug delivery system refers to a class of preparations in which drugs are absorbed through the skin through capillaries at a certain rate and enter the systemic circulation to produce drug effects. In China, transdermal drug delivery systems are collectively referred to as patches or patches. In recent years, the transdermal drug delivery system has developed rapidly, and the number of varieties has increased rapidly, which has not only attracted the attention of medical scientists, but also been welcomed by clinicians and patients. Clinical practice has proved that the transdermal drug delivery system has many advantages, such as avoiding the damage of the drug in the gastrointestinal tract by avoiding the "hepatic first-pass effect", reducing the peak and valley of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/282A61K9/70A61P29/00A61P19/02A61P9/14G01N30/02
Inventor 葛月宾李兵
Owner 葛月宾
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