Artemisia argyi leaf oil transdermal patch, preparation method and detection method for active ingredients in the patch

Abstract

The invention discloses a blumea oil transdermal patch, a preparation method thereof and a method for detecting active components contained in the blumea oil transdermal patch. The blumea oil transdermal patch comprises a back lining material, a medicated layer and a protective film, wherein the medicated layer comprises a humectant, a filling agent, a patch skeleton, a cross-linking regulating agent, a cross-linking agent, a thickening agent, an emulsifying agent and blumea oil. The blumea oil transdermal patch disclosed by the invention has the advantages of high medicine permeability and good adhesion without stimulation. The preparation method of the blumea oil transdermal patch comprises the following steps: respectively preparing a humectant phase composed of the cross-linking agent, the cross-linking regulating agent, the humectant and the patch skeleton and a water phase composed of the blumea oil, the emulsifying agent, ultrapure water, the filling agent and the thickening agent; slowly adding the humectant to the water phase, uniformly stirring and mixing to obtain a colloid, coating the colloid to the back lining material, adhering the protective film, and standing to solidify for 6-12 hours. According to the method for measuring the pharmacological active components contained in the blumea oil transdermal patch, an HP-INNOWAX capillary chromatographic column is adopted, the flowing phase is N2, the flow velocity is 0.7-1 mL.min<-1>, and the content of eucalyptol, camphor and borneol can be accurately measured.

Description

technical field [0001] The invention relates to a mugwort leaf oil transdermal patch, a preparation method and a detection method for active components in the patch. Background technique [0002] Transdermal drug delivery system refers to a class of preparations in which drugs are absorbed through the skin through capillaries at a certain rate and enter the systemic circulation to produce drug effects. In China, transdermal drug delivery systems are collectively referred to as patches or patches. In recent years, the transdermal drug delivery system has developed rapidly, and the number of varieties has increased rapidly, which has not only attracted the attention of medical scientists, but also been welcomed by clinicians and patients. Clinical practice has proved that the transdermal drug delivery system has many advantages, such as avoiding the damage of the drug in the gastrointestinal tract by avoiding the "hepatic first-pass effect", reducing the peak and valley of th...

AI Technical Summary

Problems solved by technology

[0004] Artemisia argyi volatile oil (referred to as Artemisia argyi oil) is one of its main active ingredients. It is known that it has pharmacological effects such as antitussive and asthma, liver and gallbladder protection, antibacterial and antiviral, and immune function enhancement. However, at present, Artemisia argyi oil is mainly prepared into soft capsules , dripping pills, nanoemulsions and other dosage forms affect their efficacy. Although there are a small number of transdermal patch dosage forms, the formulas are relatively simple, and their performance in adhesion, cohesion and permeability is not good, and continuous improvement is still needed

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