A kind of pharmaceutical composition and its application

A composition and drug technology, applied in the direction of drug combination, active ingredients of anhydride/acid/halide, nervous system diseases, etc., can solve the problems of child ADHD without atomoxetine hydrochloride and taurine, and achieve Effects of promoting SOD activity, reducing spontaneous hyperactivity behavior, and inhibiting MDA level

Active Publication Date: 2016-08-31
CHONGQING TECH & BUSINESS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is currently no research on the combination of atomoxetine hydrochloride and taurine for the treatment of ADHD in children, and the study of the combination of the two has good prospects and application value for ADHD in children

Method used

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  • A kind of pharmaceutical composition and its application
  • A kind of pharmaceutical composition and its application
  • A kind of pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 The effect of the pharmaceutical composition provided by the present invention on the juvenile stage SHR rat ADHD model

[0045] 1), experimental design

[0046] 54 newborn 21-day-old SHR rats ADHD model and 9 WKY rats were taken. After 3 days of adaptive feeding, 52 SHR rats were randomly divided into 6 groups according to body weight, 8-9 rats / group.

[0047] In the experiment, WKY rats were used as negative control;

[0048] The ADHD model of SHR rats without administration was used as the blank control;

[0049] The rats given only atomoxetine hydrochloride were used as the positive control group;

[0050] Three experimental groups with different dosages were set up: among them, experimental group 1 was given a high dose of the pharmaceutical composition, experimental group 2 was given a middle dose of the pharmaceutical composition, and experimental group 3 was given a low dose of the pharmaceutical composition. Administration dosage is as shown in ...

Embodiment 2

[0087] As shown in Table 5, compared with the blank control group, using atomoxetine hydrochloride alone can significantly (P<0.05) up-regulate the brain DBH, TH and Fos expression, and the pharmaceutical composition provided by the invention can be more significant (P<0.05) 0.01) up-regulate the expression of DBH, TH and Fos in the brain, suggesting that atomoxetine hydrochloride, taurine or taurine combined with atomoxetine have a positive effect on noradrenergic neurons and dopaminergic neurons in ADHD rats Protective effect, and the combination of the two drugs has a more significant effect than the single drug. Example 2 Effect of the pharmaceutical composition provided by the present invention on 6-OHDA neonatal rat ADHD model 1), animal modeling and group administration

[0088] When the newborn rats were 5 days old, they were randomly divided into 7 groups, which were: normal control group, model control group, positive control group, and experimental groups 1-3.

[0...

Embodiment 3

[0119] Embodiment 3 Pharmacokinetics and brain distribution research of the pharmaceutical composition provided by the present invention

[0120] In accordance with the relevant content requirements of the "Measures for the Administration of Drug Registration" and the "Guiding Principles for Non-clinical Pharmacokinetic Research of Chemical Drugs", SD rats were used as the subjects, and the effects of atomoxetine hydrochloride alone and in combination with taurine Preliminary study on pharmacokinetics and brain distribution.

[0121] Ten SD rats were randomly divided into two groups, A and B, and fasted for 12 hours before the experiment. Group A was orally administered atomoxetine hydrochloride at a dose of 5 mg / kg; group B was orally administered atomoxetine hydrochloride and taurine at a single dose of 5 mg / kg and 0.9 g / kg, respectively. During the administration process, ensure that the SD rats take the medicine completely. Collect blank blood before administration, collec...

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Abstract

The invention relates to the technical field of medicines, in particular to a medicine composition and its application. The pharmaceutical composition provided by the invention comprises: atomoxetine hydrochloride and taurine. The combination of the two can produce a synergistic effect. The present invention finds through experiments that, compared with the administration of atomoxetine hydrochloride alone, the combination of taurine and atomoxetine hydrochloride can more significantly increase the SOD activity and GSH content in the brain tissue of juvenile ADHD model rats, and down-regulate the MDA content (P<0.01), played an anti-oxidation role, increased the expression of DBH and TH in the brain of juvenile ADHD model rats, and up-regulated the expression of Fos protein in the prefrontal cortex of the brain (P<0.01). Compared with single administration, the effect of the pharmaceutical composition is more obvious. Therefore, the pharmaceutical composition of the present invention can be used as a candidate drug for treating ADHD in children.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a medicine composition and its application. Background technique [0002] ADHD, also known as attention deficit hyperactivity disorder (ADHD) or mild brain dysfunction syndrome, is a common abnormal disease in children, and its main impact is to cause abnormal behavior in children. The main clinical manifestations of ADHD in children are: attention deficit, hyperactivity, perception disorder, emotional disturbance, maladaptation, learning difficulties, etc. The causes of the disease may be as follows: dysplasia of brain nerves, insufficient quantity of brain neurotransmitters, organic damage of brain tissue, genetic factors, and other factors. It occurs mostly in children of school age, and the age group with the highest prevalence is 6-12 years old. [0003] At present, many studies have shown that attention deficit hyperactivity disorder (ADHD) in children is mainly a mild ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/185A61P25/00A61P25/14A61K31/138
Inventor 汪程远郑旭煦殷钟意
Owner CHONGQING TECH & BUSINESS UNIV
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