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Traditional Chinese medicine composition comprising grape extract products and preparation method thereof

A composition and extract technology, applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as liver loss, metabolic disorders in the body, increase the economic burden of patients, etc., and achieve lower blood lipids and better curative effects. , Quality controllable effect

Active Publication Date: 2014-09-24
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a good effect of lowering blood lipids, but long-term use will cause muscle toxicity such as myalgia, muscle inflammation, and even rhabdomyolysis, as well as side effects such as metabolic disorders in the body, gastrointestinal adverse reactions, and liver damage.
At the same time, the price of statins is high, and long-term use will correspondingly increase the economic burden of patients

Method used

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  • Traditional Chinese medicine composition comprising grape extract products and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Get the grape skin raw material, add ethyl acetate and 70% ethanol with a volume ratio of 1:2 after pulverizing it, heat and reflux for extraction twice, the first time is 1.5 hours, the second time is 1 hour, and the filtrates are combined to obtain extract I. Add 70% ethanol to the residue, heat and reflux to extract twice, the first time for 1 hour, and the second time for 0.5 hours, the filtrates are combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and the extract is dissolved with 50% methanol , using macroporous resin AB-8 for separation, first eluted with 65% ethanol to obtain eluent I; then eluted with 85% ethanol at a flow rate of 2.5BV / h to obtain eluent II, recovered , concentrated under reduced pressure, dried, that is.

[0040] After testing, the resveratrol content is 12.01%, and the anthocyanin content is 4.46%.

Embodiment 2

[0042] Get the grape seed raw material, add ethyl acetate and 70% ethanol with a volume ratio of 1:2 after pulverizing it, heat and reflux to extract 2 times, the first time is 1.5 hours, the second time is 1 hour, and the filtrates are combined to obtain extract I. Add 70% ethanol to the residue, heat and reflux to extract twice, the first time for 1 hour, and the second time for 0.5 hours, the filtrates are combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and the extract is dissolved with 50% methanol , using macroporous resin X-5 for separation, first eluted with 70% ethanol to obtain eluent I; then eluted with 90% ethanol at a flow rate of 2BV / h to obtain eluent II, recovered, Concentrate under reduced pressure, dry, that is.

[0043] After testing, the resveratrol content was 11.18%, and the anthocyanin content was 5.53%.

Embodiment 3

[0045] Take grape skin and grape seed raw materials, crush them, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and reflux for extraction twice, the first time is 2 hours, the second time is 1 hour, and the filtrates are combined to obtain the extract I, add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 1 hour, the second time is 0.5 hours, the filtrate is combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and the extract is extracted with 50% ethanol Dissolve the extract, use macroporous resin X-5 to separate, first elute with 65% ethanol to get eluent I; then elute with 90% ethanol, the eluent flow rate is 2BV / h, get eluent II , recovery, concentration under reduced pressure, drying, that is.

[0046] After testing, the resveratrol content is 19.92%, and the anthocyanin content is 7.90%.

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Abstract

The invention discloses a traditional Chinese medicine composition comprising grape extract products, and the traditional Chinese medicine composition comprises the following components by weight: 5-20% of resveratrol and 2-8% of anthocyanins. The invention also discloses a preparation method of the traditional Chinese medicine composition, and the preparation method comprises the extraction of the effective components and the preparation of a finished product in accordance with the formula. The traditional Chinese medicine composition is prepared by full use of raw material medicines for scientific proportioning, the coordination effect is produced, the blood fat is reduced, and compared with a traditional preparation, the traditional Chinese medicine composition has better effect, and is more controllable in quality, and suitable for industrialized production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition containing grape extract and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24.7% of the to...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P3/06
Inventor 杨国元李莹白洁黄永亮郁正刚崔卜东
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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