Composition for promoting physiologically regulative regeneration of damaged tissue as well as preparation method and use thereof

A damaged tissue, regulating technology, applied in the biological field of physiological regulation regeneration of damaged tissue, can solve problems such as poor effect, wound scars, loss of normal skin function, etc., to improve the quality of wound healing and accelerate wound healing. Effect

Active Publication Date: 2014-09-24
高忠翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the disadvantages of existing tissue regeneration preparations, such as poor effect, easy side effects, wound scars, loss of normal skin function, and abnormal tis...

Method used

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  • Composition for promoting physiologically regulative regeneration of damaged tissue as well as preparation method and use thereof
  • Composition for promoting physiologically regulative regeneration of damaged tissue as well as preparation method and use thereof
  • Composition for promoting physiologically regulative regeneration of damaged tissue as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A varnish 1 for promoting physiologically regulated regeneration of damaged tissue, which contains the following components and contents: 5g / L albumin, 10mg / L epidermal growth factor, 5mg / L transforming growth factor α, 20mg / L keratinocyte growth Factors, 15mg / L basic fibroblast growth factor, 10mg / L platelet-derived growth factor, 10mg / L vascular endothelial growth factor, 20mg / L interleukin-8, 15mg / L granulocyte macrophage colony-stimulating factor, 3g / L collagen, 3g / L monocitric acid hydrate, 120g / L glycerin, 80g / L ethanol, and the balance is water.

Embodiment 2

[0030] The varnish 2 for promoting the physiologically regulated regeneration of damaged tissues contains the following components and contents: 12g / L albumin, 20mg / L epidermal growth factor, 40mg / L transforming growth factor α, 75mg / L keratinocyte growth Factors, 70mg / L basic fibroblast growth factor, 25mg / L platelet-derived growth factor, 22mg / L vascular endothelial growth factor, 28mg / L interleukin-8, 30mg / L granulocyte macrophage colony-stimulating factor, 12g / L hydroxyethyl cellulose, 1g / L trisodium citrate, and the balance is phosphate buffered saline (PBS).

Embodiment 3

[0032] Spray 3 that promotes the physiological regulatory regeneration of damaged tissues, the components and content of which are: 20g / L albumin, 100mg / L epidermal growth factor, 50mg / L transforming growth factor α, 100mg / L keratinocyte growth Factors, 80mg / L basic fibroblast growth factor, 80mg / L platelet-derived growth factor, 30mg / L vascular endothelial growth factor, 90mg / L interleukin-8, 75mg / L granulocyte macrophage colony-stimulating factor, 7g / L hydroxyethyl cellulose, 2g / L collagen, 3g / L trisodium citrate, and the balance is water.

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PUM

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Abstract

The invention discloses a composition for promoting physiologically regulative regeneration of a damaged tissue. The composition comprises such components as albumin, epidermal growth factor, transforming growth factor alpha, keratinocyte growth factor, basic fibroblast growth factor, platelet-derived growth factor, vascular endothelial growth factor, interleukin-8 and granulocyte-macrophage colony stimulating factor. The eight protein factors are combined for use to comprehensively develop the physiological tissue repair function; the eight protein factors functionally promote each other; based on the own physiological tissue recovery mechanism of the human body, the wound healing is accelerated and the wound healing quality is improved, including recovering the structure and the functions of the normal skin tissue. Each cell factor-containing component has clear mechanism of action without any potential toxic and side effect and objectionable odor. Such a combined recovery agent is capable of recovering the normal structure and the physiological functions of tissues more quickly under the physiological conditions of the human body.

Description

technical field [0001] The invention relates to the biotechnical field of physiologically regulated regeneration of damaged tissue, in particular to a composition for promoting the physiologically regulated regeneration of damaged tissue, a preparation method and application. Background technique [0002] Skin ulcer is a common refractory disease caused by a variety of reasons. It is a skin or mucosal defect caused by ischemia or necrosis of the dermis or deep skin tissue. Causes of skin ulcers include vascular ulcers (arteriosclerotic ulcers, varicose ulcers), traumatic ulcers, infectious ulcers, chemical ulcers, radiation ulcers, pressure ulcers, neurotrophic ulcers, diabetic ulcers, Snakebite ulcers, ulcers on scars after burns, etc. Due to the poor nutritional status of local tissues, blood circulation disorders and low resistance, repeated infections are prone to form a vicious circle. [0003] In patients with skin ulcers, it usually takes several months for an ulcer...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61P17/02A61K38/18A61K38/20
Inventor 高忠翔冯翔石建芳
Owner 高忠翔
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