Serum protein marker for early diagnosis of lung cancer

A serum protein and early diagnosis technology, applied in the field of serum protein markers, can solve the problems that human proteins cannot be studied, it is difficult to use clinical disease early diagnosis, lack of protein quantitative technology, etc., to achieve time-sensitive cost, high complexity, pain Reduced effect

Inactive Publication Date: 2014-09-24
张海震
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

More than 95% of human proteins cannot be studied due to current lack of reliable protein quantification techniques
There are a large number of human proteins that have been proven to be biomarkers associated with certain diseases, but due to the lack of effective protein quantification techniques, it is difficult for them to be used for early diagnosis of clinical diseases

Method used

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Embodiment Construction

[0013] The specific embodiment of the present invention will be described in further detail below through specific examples.

[0014] A serum protein marker for early diagnosis of lung cancer, wherein the marker is composed of the following components:

[0015] CD44, SCC, CEA, CYFRA21-1, NNMT, CA125, NSE, FDG, TPS, GRP.

[0016] A serum protein marker for early diagnosis of lung cancer, wherein the detection method is:

[0017] Quantitative detection of serum protein was performed by immunomultiple reaction mass spectrometry, the above-mentioned markers were added to the analyte, and the captured samples were eluted using magnetic beads with immobilized anti-polypeptide antibodies and analyzed by MRM-MS to obtain the final detection results.

[0018] For immuno-MRM, biological samples contain abundant peptide analytes, stable isotope-labeled standards are added to the analytes, and the captured samples are eluted using magnetic beads immobilized with anti-peptide antibodies f...

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Abstract

The invention relates to a serum protein marker for the early diagnosis of lung cancer. The marker comprises CD44, SCC, CEA, CYFRA21-1, NNMT, CA125, NSE, FDG, TPS and GRP. The biological protein marker in the serum of a suspected patient is analyzed to realize the early diagnosis of lung cancer. The probability of transformation of a lung cyst into a malignant tumor can be sensitively detected by virtue of changes in the protein concentration of the biological marker, so that the time for the diagnosis and treatment of lung cancer is gained.

Description

technical field [0001] The invention relates to a marker, in particular to a serum protein marker for early diagnosis of lung cancer. Background technique [0002] The mortality rate of lung cancer is the highest in the world. One of the main reasons is that the early diagnosis of lung cancer does not have mature means. When the tumor is discovered, most of them are in the middle and late stages. Coupled with the extremely fast lesion rate of lung cancer tumors, early diagnosis of lung cancer becomes the key to diagnosis and treatment of lung cancer and prolonging the life of patients. [0003] Early diagnosis of cancer is an international problem. However, early diagnosis of diseases plays a vital role in the treatment and prevention of diseases. For example, early diagnosis of cancer can more effectively remove tumor cells in tissues, which can double the survival rate of patients. However, tumor cells in the early stage of cancer are small in size and difficult to dete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/57423G01N33/57488G01N33/6848
Inventor 张海震
Owner 张海震
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