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A thixotropic hydrogel loaded with dual drugs for local tumor treatment and preparation method thereof

A local treatment and thixotropic technology, applied in the field of biomedicine, can solve the problems of reducing the therapeutic efficiency of chemotherapy drugs, low solubility of curcumin, poor bioavailability, etc., and achieve good biocompatibility, biodegradability and biosafety Maintain and reduce the effect of dosage

Active Publication Date: 2016-05-18
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Systematic chemotherapy is one of the main methods of clinical treatment of cancer today. However, systemic administration of chemotherapy drugs through intravenous injection has great defects: first, intravenous injection of the maximum tolerated dose of anti-tumor drugs will cause serious damage to healthy organs, Such as cardiomyopathy, leukopenia, etc.; secondly, because systemic administration is not targeted, and various barriers such as blood circulation system and reticuloendothelial tissue need to be overcome, the therapeutic efficiency of chemotherapy drugs is reduced
However, the solubility of curcumin in water is extremely low (11ng / mL), resulting in poor bioavailability, which limits clinical use

Method used

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  • A thixotropic hydrogel loaded with dual drugs for local tumor treatment and preparation method thereof
  • A thixotropic hydrogel loaded with dual drugs for local tumor treatment and preparation method thereof
  • A thixotropic hydrogel loaded with dual drugs for local tumor treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Dissolve curcumin powder in 0.5mol / L sodium hydroxide aqueous solution, add it to 2% silk fibroin solution by mass fraction, mix well, add 0.1mol / L hydrochloric acid solution to adjust the pH to 7.2, and obtain a curcumin concentration of 100μg / mL curcumin / silk fibroin aqueous solution.

[0031] (2) Doxorubicin hydrochloride was dissolved in 2% hydroxypropyl cellulose aqueous solution by mass fraction, and mixed uniformly to obtain a doxorubicin / hydroxypropyl cellulose aqueous solution with a doxorubicin hydrochloride concentration of 100 μg / mL.

[0032] (3) Mix the silk fibroin solution and hydroxypropyl cellulose solution with the same mass fraction obtained in step (1) and step (2) at a mass ratio of 6:4, and the mass fraction of silk fibroin in the final mixed solution is 1.2% , the mass fraction of hydroxypropyl cellulose was 0.8%, the concentration of curcumin was 60 μg / mL, and the concentration of doxorubicin hydrochloride was 40 μg / mL. Keep the temperature...

Embodiment 2

[0034] (1) Dissolve curcumin powder in 0.5mol / L sodium hydroxide aqueous solution, add it to 20% silk fibroin protein solution by mass fraction, mix evenly, add 0.1mol / L hydrochloric acid solution to adjust the pH to 7.2, and obtain a curcumin concentration of 2100μg / mL curcumin / silk fibroin aqueous solution.

[0035] (2) Doxorubicin hydrochloride powder was dissolved in 20% hydroxypropyl cellulose aqueous solution by mass fraction, and mixed evenly to obtain a doxorubicin / hydroxypropyl cellulose aqueous solution with a doxorubicin hydrochloride concentration of 8000 μg / mL.

[0036] (3) Mix the silk fibroin solution and hydroxypropyl cellulose solution with the same mass fraction obtained in step (1) and step (2) at a mass ratio of 9:1, and the mass fraction of silk fibroin in the final mixed solution is 18% , the mass fraction of hydroxypropyl cellulose was 2%, the concentration of curcumin was 1890 μg / mL, and the concentration of doxorubicin hydrochloride was 800 μg / mL. Pl...

Embodiment 3

[0038] (1) Dissolve curcumin powder in 0.5mol / L sodium hydroxide aqueous solution, add it to 2% silk fibroin aqueous solution by mass fraction, mix well, add 0.1mol / L hydrochloric acid solution to adjust the pH to 7.2, and obtain a curcumin concentration of 200μg / mL curcumin / silk fibroin aqueous solution.

[0039] (2) Doxorubicin hydrochloride powder was dissolved in 2% hydroxypropyl cellulose aqueous solution by mass fraction, and mixed uniformly to obtain a doxorubicin / hydroxypropyl cellulose aqueous solution with a doxorubicin hydrochloride concentration of 100 μg / mL.

[0040] (3) Mix the silk fibroin solution and hydroxypropyl cellulose solution with the same mass fraction obtained in step (1) and step (2) at a mass ratio of 9:1, and the mass fraction of silk fibroin in the final mixed solution is 1.8% , the mass fraction of hydroxypropyl cellulose was 0.2%, the concentration of curcumin was 180 μg / mL, and the concentration of doxorubicin hydrochloride was 10 μg / mL. Keep t...

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Abstract

The invention belongs to the technical field of biomedicines, and particularly relates to a double-drug loaded thixotropic hydrogel for tumor local treatment and a preparation method thereof. The thixotropic hydrogel can be used for treating tumors by local injection including but not limited to intratumor injection, peritumoral injection and the like), and comprises the following components in percentage by mass: 1.2-18 percent of silk fibroin and 0.2-8 percent of hydroxy propyl cellulose, wherein the mass ratio of silk fibroin to hydroxy propyl cellulose is 1.5-9; and the anti-cancer medicament comprises 60-1900 mu g / mL curcumin and 10-3200 mu g / mL of doxorubicin hydrochloride. The drug loaded hydrogel has thixotropic syringeability and long-time drug sustained-release effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a thixotropic hydrogel loaded with dual drugs for local treatment of tumors and a preparation method thereof. Background technique [0002] Cancer is a leading cause of human death, currently claiming more than 8 million lives worldwide each year. Systematic chemotherapy is one of the main methods of clinical treatment of cancer today, but systemic administration of chemotherapy drugs through intravenous injection has great defects: first, intravenous injection of the maximum tolerated dose of anti-tumor drugs will cause serious damage to healthy organs, Such as cardiomyopathy, leukopenia, etc.; secondly, because systemic administration is not targeted, and various barriers such as blood circulation system and reticuloendothelial tissue need to be overcome, the therapeutic efficiency of chemotherapy drugs is reduced. Local drug delivery to tumors has attracted mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/10A61P35/00A61K31/12
Inventor 邵正中曹涵杨宇红陈新吴江涛
Owner FUDAN UNIV
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