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Traditional Chinese medicine composition for treating stroke, and preparation method, pharmaceutical preparation and application thereof

The technology of a pharmaceutical preparation and composition is applied in the field of traditional Chinese medicine composition for treating stroke and its preparation field, which can solve the problems of heavy medical treatment, economic and social burden, large dosage for patients, endangering the health of patients, etc. Clear ingredients and controllable quality

Active Publication Date: 2014-10-01
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the results of the third sampling survey on causes of death among Chinese residents released in 2008, stroke has become the number one cause of death among Chinese nationals, with a death rate 4-5 times higher than that in European and American countries, and the vast majority of stroke survivors will have hemiplegia , aphasia and even blindness and other serious sequelae, which seriously endanger the health of patients and affect their quality of life, and also bring heavy medical, economic and social burdens to patients' families and society
[0006] A Chinese patent CN1507910A discloses a pharmaceutical composition for the treatment of stroke. The active ingredients of the pharmaceutical composition are made of pangolin and Acanthopanax. It adopts the traditional extraction method, and the ointment rate is high, but the patient takes a large dose.

Method used

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  • Traditional Chinese medicine composition for treating stroke, and preparation method, pharmaceutical preparation and application thereof
  • Traditional Chinese medicine composition for treating stroke, and preparation method, pharmaceutical preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049]Take 10kg of pangosaurus, crush it into a coarse powder, add 100L of 70% v / v ethanol to extract three times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to a relative density of 1.03-1.08 (60°C), add water to dilute to the concentration of the sample solution 2g / mL (based on crude drug amount), adsorbed with 10L D101 macroporous resin (resin diameter-to-height ratio 1:8), adsorption flow rate 2BV / h, first eluted with 5BV water, then 50%v / v ethanol 5BV, The elution flow rate is 2BV / h, the 50% v / v ethanol eluate is collected, the ethanol is recovered, and dried under reduced pressure to obtain 500 g of the effective part of Pangosaurus. It contains 260g of pangolin total saponins.

[0050] Take another 5kg of Acanthopanax, crush it into coarse powder, add 35L of 75% v / v ethanol, reflux extraction 3 times, each time for 4 hours, filter, combine the filtrates, recover ethanol, and concentrate under reduced pressure to a relative density o...

Embodiment 2

[0054] Take 10kg of the herb, crush it into a coarse powder, add 80L of 30% v / v ethanol to reflux and extract three times, each time for 1 hour, filter, combine the extracts, recover the solvent, concentrate until there is no alcohol smell, dilute with water to 20L, centrifuge, and pour The supernatant was diluted with water to a concentration of 1 g / mL (calculated as the amount of crude drug), adsorbed with 10LHPD100 macroporous resin (resin diameter-to-height ratio 1:4), and the adsorption flow rate was 1BV / h. Elution with v / v ethanol 4BV, elution flow rate 4BV / h, collect 70% v / v ethanol eluate, recover ethanol, spray dry, and obtain 470g of effective parts of pangolinus. It contains 280g of pangolin total saponins.

[0055] Take another 6kg of Acanthopanax, crush it into coarse powder, add 30L of 50% v / v ethanol, cold soak and extract three times, 24 hours each time, combine the extracts, recover the solvent, concentrate under reduced pressure until no alcohol smell, add wa...

Embodiment 3

[0059] Take 8kg of pangosaurus, crush it into a coarse powder, add 80L50%v / v ethanol for cold extraction three times, 24h each time, filter, combine the three extracts, recover the solvent, concentrate until there is no alcohol smell, add water to dilute to the concentration of the sample solution 1.5g / mL (based on crude drug amount), adsorbed with 5L NKA-9 macroporous resin (resin diameter-to-height ratio 1:15), adsorption flow rate 5BV / h, first eluted with 4BV of water, and then washed with 8BV of 60%v / v ethanol Elution, the elution flow rate is 1BV / h, collect 60% v / v ethanol eluate, concentrate, and freeze-dry to obtain 320g of the effective part of pangolinus. It contains 231g of pangolin total saponins.

[0060] Another 10kg of Acanthopanax senticosus was crushed into coarse powder, decocted in 100L water three times, 2 hours each time, filtered, combined three times, recovered solvent, concentrated to relative density 1.2 (60°C), added ethanol to make it contain alcohol...

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Abstract

The invention provides a traditional Chinese medicine composition for treating stroke; the traditional Chinese medicine composition comprises an effective part of rhizoma dioscoreae nipponicae and an effective part of acanthopanax as the active components, wherein the sum of total saponins of rhizoma dioscoreae nipponicae in the effective part of rhizoma dioscoreae nipponicae and general flavones of acanthopanax in the effective part of acanthopanax is 50-90% w / w of the traditional Chinese medicine composition. The invention further provides a preparation method of the traditional Chinese medicine composition, a pharmaceutical preparation containing the traditional Chinese medicine composition, and an application of the traditional Chinese medicine composition or the pharmaceutical preparation in preparation of a medicine for treating qi deficiency and blood stasis in the recovery phase of stroke (cerebral infarction). Pharmacological experimental results show that the traditional Chinese medicine composition has good effects for protecting cerebral ischemia, invigorating the circulation of blood and dispersing blood stasis; furthermore, the material basis is more definite; the chemical components are more clear; the quality is more controllable; the dosage is reduced; and the traditional Chinese medicine composition disclosed by the invention is convenient to take, corresponds with modern requirements, and has a good development prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine composition for treating apoplexy, a preparation method, a pharmaceutical preparation and application thereof. Background technique [0002] Stroke is one of the major diseases that threaten human life and health in today's society. The number of stroke deaths in developing countries is twice that of developed countries. 1 / 3 of stroke patients die within six months of onset, 90% of survivors have sequelae of varying degrees, and half of them lose the serious sequelae of self-care and work ability; 1 / 3 of stroke patients relapse within 3-5 years seizures until death. Due to the high morbidity rate, high mortality rate, high disability rate, high recurrence rate and many complications of this disease, the medical community listed it as one of the three major diseases threatening human health along with coronary heart disease and cancer. At present, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P9/10
Inventor 孙卫郑雅楠廖茂梁张铁军
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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