Mesoporous hemostatic particles having antibacterial properties and their preparation method and use

Abstract

The invention discloses mesoporous hemostatic particles having antibacterial properties and their preparation method and use. The mesoporous hemostatic particle comprises silver and mesoporous silica and silver is uniformly distributed in the skeleton of the mesoporous silica. The mesoporous hemostatic particles having antibacterial properties are spherical and have an average particle size of 450-700 micrometers. By self-assembling and modeling effects of a surfactant, a silver source and a silicon source as raw materials are subjected to a sol-gel process to form sol, the sol is aged and dried to form silver-containing silica xerogel powder, the xerogel powder and an assistant are mixed, a binder is sprayed on the mixture, the mixture is subjected to granulation, and the hemostatic particle blanks are subjected to sintering setting to form the mesoporous hemostatic particles having antibacterial properties. The mesoporous hemostatic particles having antibacterial properties can be directly used or be used after being put into a non-woven fabric bag, and has the advantages of good hemostatic effects, no agglomeration, no flying dust, low hygroscopicity, operation easiness, storage easiness, carrying easiness, low cost and process simpleness.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a mesoporous hemostatic particle with antibacterial properties and its preparation method and application. Background technique [0002] Bleeding is a prominent manifestation of trauma, therefore, hemostasis is the basic task of trauma care. Effective hemostasis can reduce bleeding, preserve effective blood volume, and prevent shock. Therefore, timely and effective hemostasis is an important technology to save lives, reduce mortality, and win further treatment time for the wounded. In addition, because the surface of the wound generally has a warm and humid environment, pathogens such as Staphylococcus aureus, Candida, and Escherichia coli multiply quickly on the wound and easily cause wound infection. Therefore, while stopping bleeding, wound infection should also be avoided. [0003] Most of the existing hemostatic agents are used in the form of powder, which has thre...

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Problems solved by technology

[0004] (1) Scattering: Whether the powdered hemostatic product is used for home use or clinical use, there will be dust pollution from the powder material, which will affect the operating environment;

[0005] (2) Difficulty in debridement: because the hemostatic powder is directly sprinkled on the wound to achieve the purpose of rapid hemostasis, but because the hemostatic powder coagulates with the blood, it increases the difficulty of debridement after the wound stops bleeding. At the same time, the debridement process will increase the pain of the patient;

[0006] (3) No antibacterial and anti-inflammatory function: the wound surface will produce secretions during the hemostasis and healing process, which will contaminate the wound and form new wounds and complications. Traditional hemostatic agents mainly play a hemostatic effect on bleeding wounds, and their functions and therapeutic effects are single , poor antibacterial and anti-inflammatory functions

[0007] A new type of hemostatic agent - mesoporous silicon-based powder, with large specific surface area, strong water absorption, and ideal hemostatic effect, but the finer the powder, the stronger the scattering, adhesion, aggregation and hygroscopicity, which seriously affects the use environment and functional efficacy

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