Mesoporous hemostatic particles having antibacterial properties and their preparation method and use

A technology of hemostatic granules and hemostatic powder, applied in the field of biomaterials, can solve the problems of high difficulty in debridement, poor antibacterial and anti-inflammatory, affecting the use environment and functional efficacy, etc.

Active Publication Date: 2014-11-19
苏州佰济生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) Scattering: Whether the powdered hemostatic product is used for home use or clinical use, there will be dust pollution from the powder material, which will affect the operating environment;
[0005] (2) Difficulty in debridement: because the hemostatic powder is directly sprinkled on the wound to achieve the purpose of rapid hemostasis, but because the hemostatic powder coagulates with the blood, it increases the difficulty of debridement after the wound stops bleeding. At the same time, the debridement process will increase the pain of the patient;
[0006] (3) No antibacterial and anti-inflammatory function: the wound surface will produce secretions during the hemostasis and healing process, which will contaminate the wound and form new wounds and complications. Traditional hemostatic agents mainly play a hemostatic effect on bleeding wounds, and their functions and therapeutic effects are single , poor antibacterial and anti-inflammatory functions
[0007] A new type of hemostatic agent - mesoporous silicon-based powder, with large specific surface area, strong water absorption, and ideal hemostatic effect, but the finer the powder, the stronger the scattering, adhesion, aggregation and hygroscopicity, which seriously affects the use environment and functional efficacy

Method used

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  • Mesoporous hemostatic particles having antibacterial properties and their preparation method and use
  • Mesoporous hemostatic particles having antibacterial properties and their preparation method and use
  • Mesoporous hemostatic particles having antibacterial properties and their preparation method and use

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preparation example Construction

[0058] The preparation method of antibacterial hemostatic granule of the present invention, comprises the following steps:

[0059]a) Dissolve the surfactant in a polar solvent, add the silver source and then add the silicon source, adjust the pH of the system to 2-10, obtain the sol through the sol-gel process, age and dry the sol to obtain silver-containing silicon Xerogel-based hemostatic powder, optionally, mixing the obtained hemostatic powder with an auxiliary agent to obtain a powder;

[0060] (b) Spray the binder solution on the hemostatic powder or powder obtained in step (a) in a granulator, then granulate, and dry and sieve to obtain a hemostatic particle base of 500 microns to 700 microns;

[0061] (c) sintering and shaping the hemostatic particle base obtained in step (b) to obtain antibacterial hemostatic particles with an average particle size of 450 microns-700 microns,

[0062] in,

[0063] The silver source is one or a combination of two or more of silver n...

Embodiment 1

[0102] Preparation of Antibacterial Hemostatic Granules

[0103] Dissolve 3g of P123 (polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer) in 140g of deionized water, mix well, place in a water bath at 35°C, add 1g of AgNO 3 Keep stirring for 4-5 hours in the dark, then add 10g TEOS (tetraethyl orthosilicate) drop by drop, adjust the pH value to about 2 with nitric acid, stir evenly, raise the temperature to 60°C and continue stirring, and react for 5 hours to obtain a stable and transparent The sol, the sol is aged, washed and dried to constant weight to obtain a silicon dioxide powder containing Ag containing P123 ( figure 1 ).

[0104] Mix 10g of silicon dioxide powder containing silver and P123 with 1g of starch to obtain a powder, add it to a swash plate granulator, spray about 10g of an aqueous solution of 5% (w / w) natural clay, and make the powder and aqueous solution In close contact with each other, the spheronizing speed is 80rpm, and the s...

Embodiment 2

[0109] Preparation of Antibacterial Hemostatic Granules

[0110] Dissolve 20g of CTAB (cetyltrimethylammonium bromide) in 400g of deionized water, mix well, place in a water bath at 35°C, add 9g of AgNO 3 Keep stirring for 4-5 hours after avoiding light, then add 75g TEOS (tetraethyl orthosilicate) drop by drop, adjust the pH value to about 10 with NaOH, stir evenly, raise the temperature to 60°C and continue stirring, and react for 5 hours to obtain a stable and transparent The sol is aged, washed, and dried to constant weight to obtain a silicon dioxide powder containing Ag and CTAB.

[0111] 0.5g carboxymethyl cellulose is dissolved in water to prepare 2.5% (w / w) binder solution liquid material, 10g silicon dioxide powder containing Ag and CTAB is added in the swash plate granulator, sprayed into the solution There is about 30g of liquid material of carboxymethyl cellulose, so that silicon dioxide and liquid material are in close contact with each other to form agglomerate...

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Abstract

The invention discloses mesoporous hemostatic particles having antibacterial properties and their preparation method and use. The mesoporous hemostatic particle comprises silver and mesoporous silica and silver is uniformly distributed in the skeleton of the mesoporous silica. The mesoporous hemostatic particles having antibacterial properties are spherical and have an average particle size of 450-700 micrometers. By self-assembling and modeling effects of a surfactant, a silver source and a silicon source as raw materials are subjected to a sol-gel process to form sol, the sol is aged and dried to form silver-containing silica xerogel powder, the xerogel powder and an assistant are mixed, a binder is sprayed on the mixture, the mixture is subjected to granulation, and the hemostatic particle blanks are subjected to sintering setting to form the mesoporous hemostatic particles having antibacterial properties. The mesoporous hemostatic particles having antibacterial properties can be directly used or be used after being put into a non-woven fabric bag, and has the advantages of good hemostatic effects, no agglomeration, no flying dust, low hygroscopicity, operation easiness, storage easiness, carrying easiness, low cost and process simpleness.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a mesoporous hemostatic particle with antibacterial properties and its preparation method and application. Background technique [0002] Bleeding is a prominent manifestation of trauma, therefore, hemostasis is the basic task of trauma care. Effective hemostasis can reduce bleeding, preserve effective blood volume, and prevent shock. Therefore, timely and effective hemostasis is an important technology to save lives, reduce mortality, and win further treatment time for the wounded. In addition, because the surface of the wound generally has a warm and humid environment, pathogens such as Staphylococcus aureus, Candida, and Escherichia coli multiply quickly on the wound and easily cause wound infection. Therefore, while stopping bleeding, wound infection should also be avoided. [0003] Most of the existing hemostatic agents are used in the form of powder, which has thre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/18A61L15/44A61K9/16A61K33/38A61P7/04A61K33/00
Inventor 刘昌胜洪华袁媛王成伟
Owner 苏州佰济生物科技有限公司
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