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Piroxicam-containing transdermal-absorption preparation and preparation method thereof

A technology of piroxicam and absorption enhancer, which is applied in the direction of medical preparations containing active ingredients, medical preparations without active ingredients, anti-inflammatory agents, etc., which can solve the problems of anti-inflammatory and analgesic effects, high cost, and side effects. problems, to achieve high anti-inflammatory and analgesic effects, good percutaneous absorption, and high efficacy

Active Publication Date: 2014-12-03
苏州盛泽科技创业园发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The percutaneous absorption preparation containing piroxicam disclosed in the above-mentioned patent has a high anti-inflammatory and analgesic effect without inhibiting the drug release of piroxicam, but the dosage of oxybucaine is high, the cost is high, the side effects are large, and the anti-inflammatory The analgesic effect needs to be improved

Method used

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  • Piroxicam-containing transdermal-absorption preparation and preparation method thereof
  • Piroxicam-containing transdermal-absorption preparation and preparation method thereof
  • Piroxicam-containing transdermal-absorption preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Mixed with 0.5% piroxicam / 10% levobupivacaine

[0060] A topical patch containing both piroxicam and levobupivacaine was prepared as follows:

[0061] Table 1

[0062] components

[0063] liquid paraffin

[0064] Piroxicam was previously dissolved in N-methyl-2-pyrrolidone, levobupivacaine was dissolved in toluene, and they were mixed with the remaining matrix components previously dissolved in toluene. The mixture was coated on a release film, dried to remove toluene and N-methyl-2-pyrrolidone, and bonded to a PET film support to obtain the desired transdermal preparation (adhesive layer thickness: 100 μm).

Embodiment 2～ Embodiment 6

[0066] According to the mixing shown in Table 2 below, the transdermal preparations of Examples 2 to 6 of the present invention were obtained by the method described in Example 1 above. In addition, in Table 2, the mixing of Example 1 is also described together.

[0067] Table 2

[0068]

[0069]

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Abstract

The invention relates to a piroxicam-containing transdermal-absorption preparation and a preparation method thereof. The transdermal-absorption preparation comprises piroxicam serving as an active ingredient, and levobupivacaine or pharmaceutically acceptable salt thereof serving as an absorption enhancer. According to the transdermal absorption preparation, the piroxicam has extremely excellent transdermal absorbability due to the absorption promoting effect of the levobupivacaine, and the effect is a specific effect generated by the combination of levobupivacaine and piroxicam, wherein a relatively good effect can be achieved as long as a small amount of levobupivacaine is provided. The piroxicam-containing transdermal absorption preparation, namely a patch, is extremely useful in clinical application and has a great medical effect.

Description

technical field [0001] The present invention relates to a percutaneous absorption preparation, in particular to piroxicam (Piroxicam) containing a non-steroidal anti-inflammatory analgesic as a medicinal component and levobupivacaine (Piroxicam) as a local anesthetic and as an absorption accelerator of piroxicam ( Levobupivacaine Hydrochloride) or a pharmaceutically acceptable salt thereof. Background technique [0002] Conventionally, various developments and researches have been conducted on a percutaneous absorption preparation, ie, a patch, in which various local anesthetics are mixed as transdermal absorption enhancers of non-steroidal anti-inflammatory analgesics. [0003] This is based on the consideration that, along with the release of the absorption accelerator mixed in the patch preparation, the release of the non-steroidal anti-inflammatory analgesic drug is promoted, and as a result, it shows excellent transdermal absorbability, making it effective Transdermal ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/5415A61K47/28A61P29/00
Inventor 朱忠良
Owner 苏州盛泽科技创业园发展有限公司
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