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New nonlinear polymer and preparation and use thereof

A technology of polymers and compounds, which is applied to compounds containing elements of group 8/9/10/18 of the periodic table, medical preparations containing active ingredients, drug combinations, etc., which can solve the problem of low effective rate and limited therapeutic effect And other issues

Inactive Publication Date: 2014-12-03
韩文毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, glucocorticoids, zinc oxide, mometasone furoate and other ointments are used for treatment, but the therapeutic effect is limited and the effective rate is not high
The inventor unexpectedly found that a compound has unexpected effects on the preparation of medicaments for treating eczema, and there is no report on the treatment of eczema for this type of polymer at present

Method used

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  • New nonlinear polymer and preparation and use thereof
  • New nonlinear polymer and preparation and use thereof
  • New nonlinear polymer and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071]

[0072] Example 2

Embodiment 2

[0074] The effect experiment is as follows:

[0075] The sample prepared in embodiment 1-2 is compared with the effect experiment of other various medicines. Specifically:

[0076] The first group is embodiment 1 sample group;

[0077] The second group is embodiment 2 sample group;

[0078] The third group is polyethylene glycol group;

[0079] The fourth group is Ni ion group;

[0080] The fifth group is the positive drug mometasone furoate group;

[0081] Examples of effects:

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PUM

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Abstract

The invention discloses a new nonlinear polymer containing a metal ion structure, and a preparation method and use thereof. A compound with a branch structure is used for construction of the new nonlinear polymer, and the new structure is used for testing in eczema animal models, and the new compound has excellent therapeutic effect on the treatment of eczema disease.

Description

technical field [0001] The invention discloses a non-linear polymer containing a metal ion structure as well as a preparation method and application of the polymer. Background technique [0002] Eczema includes ear eczema, hand and foot eczema, breast eczema, anal genital eczema, calf eczema, etc. Eczema can occur in any part, but it is more common in exposed parts and flexor sides; rashes are often distributed symmetrically. There are many classifications of eczema, the more common classification is divided into acute, subacute and chronic eczema according to the performance characteristics of skin lesions. Among them, acute eczema is most miliary large red papules, papules, or vesicles, with obvious punctate or small sheet erosion, exudate, and incrustation. The boundaries of the damage are unclear. Pustules, purulent exudates, and scabs may appear when co-infected; subacute eczema often develops due to improper treatment of acute stage damage, and the skin lesions are ...

Claims

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Application Information

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IPC IPC(8): C08G65/48C07F15/00A61K31/4015A61K31/765A61P17/00
Inventor 韩文毅丁镇
Owner 韩文毅
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