Preparation method of paracetamol capsule

A technology of Kahuangmin capsules and caffeine, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of uneven raw material utilization rate of raw material drug mixing, hinder the disintegration and dissolution rate of drugs, and the therapeutic effect. Not ideal and other problems, to achieve the effect of rapid disintegration and dissolution, low production cost, and improved utilization rate

Inactive Publication Date: 2014-12-24
安徽安科恒益药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the invention is to solve the problem of mixing the raw materials and granulating the raw materials in the production of Anka Huangmin Capsules in the prior art, which may easily cause uneven mixing of the raw

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: A preparation method of Ankahuangmin capsules, the raw materials include the following components: acetaminophen, caffeine, chlorpheniramine maleate, starch, fossil powder and dextrin. The raw materials are weighed, and each component includes by weight: 3 parts of acetaminophen, 6 parts of caffeine, 2 parts of chlorpheniramine maleate, 18 parts of starch, 13 parts of fossil powder, and 35 parts of dextrin. Mix acetaminophen, fossil powder, starch and dextrin in a high-speed mixing granulator. After mixing, add caffeine, chlorpheniramine maleate and ethanol to the mixed material and put it into a swinging granulator to granulate. After being granulated, it is put into the fluidized granulator, and then the material taken out of the fluidized granulator is screened. After adopting this embodiment, the content uniformity is good, the utilization rate of raw materials is improved, the medicine disintegrates and dissolves rapidly, can eliminate heat and reliev...

Embodiment 2

[0014] Embodiment 2: A preparation method of Ankahuangmin capsules, the raw materials include the following components: acetaminophen, caffeine, chlorpheniramine maleate, starch, fossil powder and dextrin. The raw materials are weighed, and each component includes by weight: 10 parts of acetaminophen, 3 parts of caffeine, 5 parts of chlorpheniramine maleate, 13 parts of starch, 7 parts of fossil powder, and 41 parts of dextrin. Mix acetaminophen, fossil powder, starch and dextrin in a high-speed mixing granulator. After mixing, add caffeine, chlorpheniramine maleate and ethanol to the mixed material and put it into a swinging granulator to granulate. After being granulated, it is put into the fluidized granulator, and then the material taken out of the fluidized granulator is screened. After adopting this embodiment, the content is more uniform, the utilization rate of raw materials is improved, the drug disintegrates and dissolves rapidly, can eliminate heat and relieve pain,...

Embodiment 3

[0015] Embodiment 3: A kind of preparation method of Anka Huangmin Capsules, the raw material comprises the following components: acetaminophen, caffeine, chlorpheniramine maleate, starch, fossil powder, dextrin, microcrystalline cellulose, lemon acid, disodium edetate, coffee tannin, xylose and glucose. The raw materials are weighed, and each component includes by weight: 13 parts of paracetamol, 4 parts of caffeine, 7 parts of chlorpheniramine maleate, 13 parts of starch, 10 parts of fossil powder, 47 parts of dextrin, 3 parts of microcrystalline cellulose, 5 parts of citric acid, 11 parts of disodium edetate, 1 part of coffee tannic acid, 4 parts of xylose, and 5 parts of glucose. Put acetaminophen, fossil powder, starch and dextrin into a high-speed mixing granulator and mix them. After mixing, add caffeine, chlorpheniramine maleate, ethanol, microcrystalline cellulose, citric acid, Disodium edetate, coffee tannin, xylose and glucose are put into a swing granulator for gr...

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PUM

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Abstract

The invention discloses a preparation method of a paracetamol capsule. The paracetamol capsule comprises the following components of acetaminophen, caffeine, chlorpheniramine maleate, starch, fossil meal and dextrin, and further comprises microcrystalline cellulose, citric acid, ethylene diamine tetraacetic acid, caffetannic acid, and one or more of xylose and glucose. The materials are weighed, blended in a high-speed blending granulator, granulated in an oscillating granulator, and put into a boiling granulator after the granulation, and then the materials taken out from the boiling granulator are screened. By adoption of the method, the utilization ratios of the materials are increased, the content uniformity of the prepared paracetamol capsule is good, the production cost is low, the medicine disintegrates and dissolves rapidly, the drug action is good, and the medicine reduces fever and stops pain, and can effectively treat nasal obstruction, headache, sore throat, fever and the like caused by cold.

Description

technical field [0001] The invention relates to a preparation method of Anka Huangmin Capsules. Background technique [0002] A cold is a disease with headache, nasal congestion, runny nose, sneezing, aversion to wind and cold, fever, and floating pulse caused by external pathogens invading the human body. There are countless medicines for treating colds all over the world, and they emerge in endlessly. As a large country with a population of 1.3 billion, our country has a huge cold medicine market, and our country has a traditional habit of using traditional Chinese medicine. There are more types of Chinese medicine, Western medicine and compound preparations for cold treatment than other countries. Anka Huangmin Capsule is a medicine suitable for relieving fever, headache, sore limbs, sneezing, runny nose, nasal congestion, sore throat and other symptoms caused by colds. In the prior art, when making Amka Huangmin Capsules, the raw materials are mixed and then granulated...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/48A61P11/00A61P29/00A61K31/4402A61K31/167
Inventor 朱卫兵姚勇周月萍张荣平
Owner 安徽安科恒益药业有限公司
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