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Improved hydroxyapatite as well as preparation method and application thereof

A modified technology of hydroxyapatite, which is applied in the fields of biomedicine and daily necessities, can solve the problems of weak bone induction, high brittleness, and difficulty in forming, and achieve the effect of improving gum bleeding symptoms, oral odor relief, and gum redness.

Active Publication Date: 2015-01-07
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, artificially synthesized hydroxyapatite still has some shortcomings in hard tissue replacement and oral health care, such as unsatisfactory physical and mechanical properties, high brittleness, weak osteoinductive effect, etc.
From the perspective of bionics, it is required to keep the HA in the bone substitute in a nano-state to avoid the agglomeration of HA particles as much as possible. Therefore, the HA particles in the traditionally used ceramic sintered body are generally above microns due to their high crystallinity. The size of natural bone apatite is very different, which limits the application, so generally only HA non-sintered body or HA slurry can be selected when preparing bone repair materials
However, the ensuing problem is that HA products can only obtain better mechanical properties through sintering. Pure HA powder or slurry has difficulty in forming, poor ability to withstand external force and liquid erosion, and cannot be used as a load-bearing bone. tissue repair materials and many other issues

Method used

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  • Improved hydroxyapatite as well as preparation method and application thereof
  • Improved hydroxyapatite as well as preparation method and application thereof
  • Improved hydroxyapatite as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0114] (a) Weigh 200 kg of hydroxyapatite and 2 kg of aluminum hydroxide, add 2.5 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid A;

[0115] (b) Weigh 45 kg of sodium chloride, 6 kg of potassium chloride, and 45 kg of magnesium chloride and mix evenly, add 3 times the amount of purified water by weight, stir to completely dissolve, filter to obtain liquid B;

[0116] (c) Mix the above liquid A and liquid B, add 10% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0117] (d) After continuously stirring the suspension at 30 rpm for 3 hours, stop stirring, leave the material to stand and age at room temperature for 24 hours, filter under pressure filtration, take the precipitate and wash it with deionized water until ...

Embodiment 2

[0119] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0120] (a) Weigh 100 kg of hydroxyapatite and 5 kg of aluminum hydroxide, add 4 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid A;

[0121] (b) Take by weighing 20 kg of sodium chloride, 2 kg of potassium chloride, and 20 kg of magnesium chloride, add 5 times the amount of purified water, stir to completely dissolve, filter to obtain liquid B;

[0122] (c) Mix the above liquid A and liquid B, add 25% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0123] (d) After the suspension was continuously stirred at 50rpm for 2 hours, the stirring was stopped, and the material was left to age at room temperature for 48 hours, filtered by pressure filtration, and the precipitate was washed with deionized water until the filtr...

Embodiment 3

[0125] The preparation method of modified hydroxyapatite described in this embodiment comprises the following steps:

[0126] (a) Weigh 100 kg of hydroxyapatite and 1 kg of aluminum hydroxide, add 2 times by weight of concentrated nitric acid (commercially available) with a mass concentration of about 68%, stir to dissolve completely, and obtain liquid A;

[0127] (b) Weigh 70 kg of sodium chloride, 10 kg of potassium chloride, and 70 kg of magnesium chloride, add 2 times the amount of purified water by weight, stir to completely dissolve, filter to obtain liquid B;

[0128] (c) Mix the above liquid A and liquid B, add 5% sodium hydroxide solution to adjust its pH value to ≥10, and form a white suspension;

[0129] (d) After the suspension was continuously stirred at 20 rpm for 6 hours, the stirring was stopped, and the material was left to age at room temperature for 12 hours, filtered by pressure filtration, and the precipitate was washed with deionized water until the filtr...

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Abstract

The invention belongs to the technical fields of biological medicines and articles of everyday use and in particular relates to improved hydroxyapatite, a preparation method of the hydroxyapatite as well as application of the hydroxyapatite in preparation of hydroxyapatite-chitosan composite gel with the effect of improving the gingivitis. Toothpaste prepared by using the improved hydroxyapatite has good effects of improving symptoms such as red and swollen gums and bleeding gums caused by the gingivitis, has a certain effect of relieving bad breath, does not have an obvious adverse reaction and also has a certain effect of improving and treating the oral mucosa ulcer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and daily necessities, and specifically relates to a modified hydroxyapatite, a preparation method thereof and an application in preparing a hydroxyapatite-chitosan composite gel capable of improving gingival inflammation. Background technique [0002] Vertebrate hard tissues (such as bones and teeth) are composites composed of organic and inorganic nano-hybrids, in which the inorganic matter is mainly nano-sized hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , Hydroxyapatite, referred to as HA], the content of hydroxyapatite in human tooth enamel is more than 95%. Synthetic hydroxyapatite has excellent biocompatibility and has a certain inducing effect on new bone growth, so it stands out among many synthetic bone substitutes and has attracted much attention. In addition, hydroxyapatite has certain remineralization, desensitization and whitening effects on oral health care. There have been many r...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/24A61K8/04A61Q11/00A61P1/02
Inventor 林艺青洪绯潘裕添沈育松
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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