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Drug composition for treating neurasthenia and preventing senile dementia

A technology for senile dementia and neurasthenia, applied in the field of biomedicine, can solve problems such as difficult to obtain raw materials and side effects of drugs, and achieve the effect of high drug efficacy, high content of active ingredients, and strong operability

Active Publication Date: 2015-01-07
YUNNAN ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the problems in the prior art that raw materials for preventing senile dementia, antidepressant and antitumor drugs are difficult to obtain, and current drugs have side effects, the present invention provides a pharmaceutical composition for treating neurasthenia and preventing senile dementia, using pure Preparation of anti-senile dementia, neurasthenia, and anti-tumor drugs from plant materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The pharmaceutical composition for treating neurasthenia and preventing senile dementia consists of the following components in mass percentage:

[0035] Garlic Neural Acid 2%,

[0036] Tofu fruit glycosides 6%,

[0037] Coixenolide 5%,

[0038] Excipients 87%,

[0039] The auxiliary materials are dextrin, lactose, sodium carboxymethyl starch, microcrystalline cellulose, and starch.

[0040] Wherein the garlic fruit nerve acid is extracted and purified according to the following steps:

[0041] (1) Remove the shell and epidermis of the garlic fruit seeds, according to the solid-liquid ratio g / mL of 10:50, mash with phosphate buffer solution with a concentration of 20mM and pH=6.0 at 4°C, and then ultrasonically pulverize 40min, extract overnight at 3°C, then filter with 4 layers of gauze, then centrifuge at 6000 r / min for 40min at 3°C, repeat twice, remove the supernatant to obtain the residue; The salt buffer solution is prepared according to the following operati...

Embodiment 2

[0052] The pharmaceutical composition for treating neurasthenia and preventing senile dementia consists of the following components in mass percentage:

[0053] Garlic Nervous Acid 1%,

[0054] Tofu glucoside 10%,

[0055] Coix Seed Lactone 10%,

[0056] Excipients 79%,

[0057] The auxiliary materials are dextrin, lactose, sodium carboxymethyl starch, microcrystalline cellulose, starch, and hydroxypropyl cellulose.

[0058] Wherein the garlic fruit nerve acid is extracted and purified according to the following steps:

[0059] (1) Remove the shell and epidermis of the garlic fruit seeds, according to the solid-to-liquid ratio g / mL of 1:30, mash with phosphate buffer solution with a concentration of 20mM and pH=7.0 at 3°C, and then ultrasonically pulverize 50min, extract overnight at 4°C, then filter with 4 layers of gauze, then centrifuge at 5000r / min at 4°C for 35min, repeat twice, remove the supernatant to obtain the residue; the phosphate buffer The solution is prepar...

Embodiment 3

[0070] The pharmaceutical composition for treating neurasthenia and preventing senile dementia consists of the following components in mass percentage:

[0071] Garlic Nervous Acid 10%,

[0072] Tofu glucoside 1%,

[0073] Coixenolide 1%,

[0074] Excipients 88%,

[0075] The auxiliary materials are dextrin, lactose, sodium carboxymethyl starch, microcrystalline cellulose, starch, and hydroxypropyl cellulose.

[0076] Wherein the garlic fruit nerve acid is extracted and purified according to the following steps:

[0077](1) Remove the shell and epidermis of the garlic fruit seeds, according to the solid-to-liquid ratio g / mL of 8:5, mash with phosphate buffer solution with a concentration of 20mM and pH=7.0 at 4°C, and then ultrasonically pulverize 30min, extract overnight at 4°C, then filter with 4 layers of gauze, then centrifuge at 8000 r / min at 4°C for 30min, repeat twice, remove the supernatant to obtain the residue; The buffer solution is prepared according to the fo...

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Abstract

The invention discloses a drug composition for treating neurasthenia and preventing senile dementia. The drug composition comprises the following raw materials in percentage by mass: 1%-10% of malania oleifera nervonic acid, 1%-10% of helicid, 1%-10% of semen coicis lactone and the balance of auxiliary materials. The drug provided by the invention is helpful for prolonging the sleeping time of old people; the semen coicis lactone is capable of preventing cancers and inhibiting proliferation of various cancer cells; malania oleifera nervonic acid, helicid and semen coicis lactone are combined for effectively preventing and controlling the occurrence of the senile dementia and healing the senile dementia; a safe and effective plant composition extracted from pure plants is provided for the whole world with increasingly severe aging problems. According to the drug composition, the raw materials are reasonable in medicine compatibility and are all from natural plants; meanwhile, a preparation method of the drug composition provided by the invention is strong in operability; especially, an extraction process is involved according to the chemical properties of the effective ingredients of various Chinese herbal medicines, and the effective ingredient content of obtained extract is high; the drug composition has the advantages of high drug effect, low clinical dosage and the like, and the process is stable and suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a pharmaceutical composition for treating neurasthenia and preventing senile dementia. Background technique [0002] With the development of my country's economy and the implementation of population policy, the age structure of my country's population has undergone great changes. China's life expectancy rose from 68.4 years in 1990 to 73.8 years in 2008, and the proportion of the elderly population in the total population is increasing. According to the data provided by the Organization for Economic Cooperation and Development, relative to China's total population, it is estimated that The proportion of the population over the age of 65 will rise from 7.8% in 2005 to 16.3% in 2030. [0003] The researchers found that after the shark's brain tissue was severely injured, it can automatically recover its function, because the shark's brain tissue contains a substance called "nervo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K36/8962A61P25/00A61P25/28C07H15/203A61K31/7034
CPCA61K9/0053A61K9/08A61K31/201A61K31/423A61K31/7034A61K36/185A61K36/8994A61K2300/00Y02P20/54
Inventor 王娟施蕊杨宇明陈中华吴飞林杨敏肖丰坤缪福俊原晓龙
Owner YUNNAN ACAD OF FORESTRY
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