Preparation method of 2-nitro-4-methyl sulfone benzoic acid

Abstract

The invention discloses a preparation method of 2-nitro-4-methyl sulfone benzoic acid. The preparation method comprises the following steps: preparing 2-nitro-4-methyl sulfone toluene in a concentrated sulfuric acid medium by using 4-methyl sulfone toluene as an initial material and nitric acid as a nitrating agent, directly adding water to dilute reaction liquid without separating the nitrating product of 2-nitro-4-methyl sulfone toluene, and dropping an oxidizing agent prepared by mixing hydrogen peroxide and concentrated sulfuric acid in the presence of a copper sulfate catalyst to prepare 2-nitro-4-methyl sulfone benzoic acid. The preparation method has the beneficial effects that 2-nitro-4-methyl sulfone benzoic acid is prepared by a one-pot process, so that the separation process of an intermediate is saved, the production process is simplified, the production cost is reduced, the yield is high, and the use amount of sulfuric acid and hydrogen peroxide is lowered. The preparation method is efficient, energy-saving, environment-friendly and more suitable for industrial production.

Description

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AI Technical Summary

Benefits of technology

This patented technology uses four different chemical reactions: 1) two steps are involved with producing 2-aminobenzonitrile (BEN), reducing manufacturing time and expenses;2) continuous use of sulphuric acid during the first step helps save on expensive materials while still providing effective results at lower temperatures than previous methods without this additionally requiring separate processes or equipment;3) utilizing copper salt instead of sulphone dichloroacetic acid as a promoter makes it easier to achieve higher yields compared to traditional methods due to its ability to reduce acidity by forming soluble salts that improve their effectiveness when mixed together with other reactants).4） making efficient and environment friendly degrading agents from H2O2.

Problems solved by technology

This patents describes methods for making certain substances from 2-aminothiachromanone (also called 1 - aminobenzimidazole) or another type of molecule known as tetrahydropathionatebenzoquinones. These compounds have various applications such as pharmaceutical products like antifungals, antihypercholesterolemics, immunosuppressants, etc., but they also find their importance due to their ability to function effectively within cells without causing harmful side effects during manufacturing processes.