Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation

A technology for sodium aescinate and hemorrhoids, which is applied in the field of medicine, can solve the problems that sodium aescinate cannot be directly applied externally, etc., and achieve the effects of improving stability, fast action, and enhancing compliance

Active Publication Date: 2015-01-21
MAYINGLONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the clinically limited problem that sodium aescinate cannot be directly applied externally in the prior art, the present invention provides a sodium aescinate preparation for treating hemorrhoids that can effectively reduce the irritation of sodium aescinate rectal mucosa

Method used

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  • Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation
  • Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation
  • Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Component:

[0044]

[0045] Preparation process:

[0046] Take sodium carboxymethyl cellulose and wet it with glycerin and disperse it into 40% purified water of the total formula, and swell for 24 hours to obtain a transparent colorless gel liquid A. Completely dissolve arginine hydrochloride and edetate disodium in 39% purified water of the total formula, add dilute hydrochloric acid and stir evenly, add to the above-mentioned gel liquid A to obtain gel liquid B. Take ethylparaben and dissolve it with a small amount of ethanol, add it into the gel liquid B, and stir evenly. Sodium aescinate is dissolved in about 4% purified water of the total formula, added into the above-mentioned gel system under negative pressure (-0.095Mpa), stirred evenly, filled, and packaged to obtain the finished preparation.

Embodiment 2

[0048] Component:

[0049]

[0050]

[0051] Preparation process:

[0052] Take sodium carboxymethyl cellulose and wet it with glycerin and disperse it in 37% purified water of the total formula, and swell for 24 hours to obtain gel liquid A. Completely dissolve arginine hydrochloride and disodium edetate in 30% purified water of the total formula, add dilute hydrochloric acid and stir evenly, add to gel liquid A to obtain gel liquid B. Dissolve the ethylparaben with a small amount of ethanol and add it to the gel liquid B, and stir evenly. Sodium aescinate is dissolved in about 8% purified water of the total formula, added to the above-mentioned gel system under negative pressure (-0.095Mpa) and stirred evenly, filled and packaged to obtain the finished preparation.

Embodiment 3

[0054] Component:

[0055]

[0056] Preparation process:

[0057]Take sodium carboxymethyl cellulose and wet it with glycerin and disperse it in 24% purified water of the total formula, and swell for 24 hours to obtain gel liquid A. Completely dissolve arginine hydrochloride and edetate disodium in 22% purified water of the total formula, add dilute hydrochloric acid and stir evenly, add to gel liquid A to obtain gel liquid B. Dissolve the ethylparaben with a small amount of ethanol and add it to the gel liquid B, and stir evenly. Sodium aescinate is dissolved in about 16% of the total formula in purified water, and the gel system is added under negative pressure (-0.09Mpa) to stir evenly, filled and packaged to obtain the finished preparation.

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Abstract

The invention discloses a sodium aescinate preparation curing haemorrhoids and a preparation method for the sodium aescinate preparation. The sodium aescinate preparation comprises the effective components of sodium aescinate and arginine hydrochloride; a gelata can be prepared by adding corresponding auxiliary materials. According to the invention, the arginine hydrochloride is adopted to reduce the thrill of the sodium aescinate to rectum mucosa; the sodium aescinate preparation directly acts on haemorrhoids part through part external administration, is fast to play function, enhances compliance of patients, and provides a novel administration route for the patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a sodium aescinate preparation for treating hemorrhoids and a preparation method thereof. Background technique [0002] Hemorrhoids belong to anorectal diseases and are one of the common clinical diseases. According to statistics, 60% of the population suffers from hemorrhoids to varying degrees. Hemorrhoids are soft venous masses formed by congestion, expansion and buckling of the hemorrhoidal venous plexus under the rectal mucosa and under the skin of the anal canal. The main clinical manifestations are bleeding, local discomfort, increased secretions, itching and prolapse. [0003] Sodium aescinin is a saponin sodium salt extracted from the dried mature seeds of Aesculus Wilsonii Rehd. Modern pharmacological studies have shown that sodium aescinate has significant effects in anti-inflammation, anti-exudation, and detumescence. It can restore the normal permeabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K47/18A61K9/06A61P9/14
CPCA61K9/0031A61K9/06A61K31/704A61K47/183
Inventor 陈平严常开江维宋爱华华烨李素娟
Owner MAYINGLONG PHARMA GROUP
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