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A plga/tio 2 Porous composite particle and its preparation method using microfluidic technology

A microfluidic technology and composite particle technology, which is applied in the field of PLGA/TiO2 porous composite particles and its preparation using microfluidic technology, can solve the problems of porogen residue and uneven hole size

Inactive Publication Date: 2016-08-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the size of the pores produced by this method is not uniform enough, and there is a problem of residual porogens

Method used

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  • A plga/tio <sub>2</sub> Porous composite particle and its preparation method using microfluidic technology
  • A plga/tio <sub>2</sub> Porous composite particle and its preparation method using microfluidic technology
  • A plga/tio <sub>2</sub> Porous composite particle and its preparation method using microfluidic technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The microfluidic chip made by photolithography is used as a device for preparing composite particles, that is, a layer of 200 μm photoresist is cast on a single crystal silicon wafer, and then the designed mask pattern ( figure 1 (shown) below is exposed for 1000s, and then the unexposed photoresist is washed away by developing to obtain the designed pattern. Then, the pattern obtained on the single crystal silicon is overmolded with polydimethylsiloxane PDMS to form a microchannel, and then this channel is used for oxygen plasma sealing with glass for 10 minutes to obtain the following: figure 1 The setup for preparing composite particles is shown. Weigh 0.2g PLGA (M w =30 kDa) and 1g TBT were added to 10ml dimethyl carbonate as the dispersed phase; 10wt% glycerol in 2wt% PVA aqueous solution was added as the continuous phase. When the flow rate of the continuous phase is 2ml / h and the flow rate of the dispersed phase is 0.2ml / h, that is, when the flow rate ratio is ...

Embodiment 2

[0040] The microfluidic chip made by photolithography is used as a device for preparing composite particles, that is, a layer of 200 μm photoresist is cast on a single crystal silicon wafer, and then the designed mask pattern ( figure 1 Shown) Expose for 1000s below, and then wash off the unexposed photoresist by developing to get the designed pattern. Then, the pattern obtained on the monocrystalline silicon is overmolded with polydimethylsiloxane PDMS to form a microchannel, and then this channel is used for oxygen plasma sealing with glass for 10 minutes to obtain the following: figure 1 The setup for preparing composite particles is shown. Weigh 0.6g PLGA (M w =50 kDa) and 0.8g TBT were added to 10ml dichloromethane as the dispersed phase; 30wt% glycerol was added to 5wt% PVA aqueous solution as the continuous phase. When the flow rate of the continuous phase is 2ml / h and the flow rate of the dispersed phase is 0.25ml / h, that is, when the flow rate ratio is 8:1, an oil-i...

Embodiment 3

[0043] The microfluidic chip is made by laser etching as a device for preparing composite particles, that is, the designed pattern is printed out by laser etching silicon wafer ( figure 1 As shown), the thickness is about 200 μm, and then the obtained pattern on the silicon wafer is molded by PDMS to form a microchannel, and then the channel is sealed with glass by oxygen plasma for 8 minutes to obtain the following figure 1 The setup for preparing composite particles is shown. . Weigh 1.2g PLGA (M w =100 kDa) and 0.4g TBT were added to 10ml chloroform as the dispersed phase; adding 50wt% glycerol in 2wt% PVA aqueous solution was used as the continuous phase. When the flow rate of the continuous phase is 1.8ml / h and the flow rate of the dispersed phase is 0.3ml / h, that is, when the flow rate ratio is 6:1, an oil-in-water single emulsion is formed by shearing. The prepared droplets were collected in 4wt% PVA aqueous solution and placed at 20°C for 12h to obtain PLGA / TiO 2 C...

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Abstract

The present invention discloses PLGA / TiO2 porous composite particles and a preparation method applying a microfluidic technology. The preparation method comprises: a, adopting a micro-processing technology to produce a microfluidic chip; b, dispersing PLGA and an organic titanate in an organic solvent to form a mixed solution adopted as a dispersed phase; c, dissolving PVA in pure water, and adding a certain percentage of glycerol, wherein the obtained solution is adopted as a continuous phase; d, injecting the dispersed phase and the continuous phase into the microfluidic chip, and regulating the flow rate ratio between the two phases to form a single emulsion in the micro-channel; e, collecting the prepared droplets into the PVA aqueous solution, and placing for a certain time at a certain temperature to obtain the cured composite particles; and f, filtering, completely washing the collected composite particles with deionized water, and drying in an oven. The prepared PLGA / TiO2 composite particles have characteristics of a variety of different morphologies and porous particle internal.

Description

technical field [0001] The invention relates to an inorganic-organic composite particle and a preparation method thereof, in particular to a PLGA / TiO2 porous composite particle and a preparation method using microfluidic technology. Background technique [0002] Microfluidic technology is a technology that precisely manipulates, processes and controls fluids or samples at the micro-nano scale. The micro-nano particles prepared by this technology have uniform particle size, good monodispersity, and various appearance shapes. In general, the preparation of micro-nanoparticles in various shapes such as spheres, ellipsoids, discs, and rods in microfluidic channels is achieved by photopolymerization [Sugiura, S.; Oda, T.; Izumida, Y.; Aoyagi, Y.; Satake, M.; Ochiai,A.; Ohkohchi, N.; Nakajima, M., Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials 2005, 26,(16) , 3327-3331. Dendukuri, D.; Tsoi, K.; Hatton, T. A.; Doyle, P. S., C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08L29/04C08K3/22C08J9/28C08J3/12
Inventor 董华唐冠男
Owner SOUTH CHINA UNIV OF TECH