High-efficient anti-quenching neodymium-doped rare earth infrared fluorescent probe and synthetic method thereof

A fluorescent probe, neodymium-doped technology, applied in the direction of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of reducing fluorescence intensity, achieve high fluorescence quantum yield, and improve the down-conversion fluorescence quantum of neodymium The effect of yield and fluorescence stability, strong anti-fade effect

Inactive Publication Date: 2015-02-04
FUDAN UNIV
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Problems solved by technology

However, for the reported Nd 3+ For fluorescent probes, the fluorescence intensity is often affected by the contact between the luminescent center and the outside world. For example, th

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  • High-efficient anti-quenching neodymium-doped rare earth infrared fluorescent probe and synthetic method thereof
  • High-efficient anti-quenching neodymium-doped rare earth infrared fluorescent probe and synthetic method thereof
  • High-efficient anti-quenching neodymium-doped rare earth infrared fluorescent probe and synthetic method thereof

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Example Embodiment

[0020] Example 1:

[0021] (1) Preparation of the shell precursor. Preparation of Gd-OA (0.1 M) precursor: Take a 50 mL three-necked round bottom flask as a reaction vessel, and add 2.5 mmol GdCl in sequence 3 , 10 mL oleic acid (OA), 15 mL octadecene (ODE). Under vacuum and magnetic stirring conditions, it was heated to 140 degrees Celsius and kept for 1 hour, and finally a clear and transparent Gd-OA (0.1 M) precursor was obtained.

[0022] Preparation of Na-TFA-OA precursor: Take a 25 mL three-necked round bottom flask as a reaction vessel, add 4 mmol sodium trifluoroacetate and 10 mL oleic acid successively, and dissolve at room temperature under vacuum and stirring conditions to obtain a colorless, transparent and clear Na-TFA-OA precursor solution.

[0023] (2) Synthesis of down-conversion luminous core. Take a 50 mL three-necked round bottom flask as the reaction vessel, and first add 0.95 mmol GdCl 3 , 0.5 mmol NdCl 3 Then add 6 mL oleic acid (OA) and 15 mL octadecene (OD...

Example Embodiment

[0026] Example 2: The surface of the neodymium-doped rare earth core-shell structure nanocrystals prepared in Example 1 with high efficiency and anti-quenching is hydrophobic, and the obtained nanocrystals can be made water-soluble by modifying them with amphiphilic molecules, so that they have better properties. Biocompatibility. Through fluorescence spectroscopy, we found that the core-shell structured nanocrystals synthesized by the continuous layer-by-layer growth method have higher anti-quenching effect than the core-shell structured nanocrystals synthesized by the traditional cladding method, and when the encapsulated shell layer The thicker, the stronger the anti-quenching effect.

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Abstract

The invention belongs to the technical field of nano-biomaterials and particularly provides a high-efficient anti-quenching neodymium-doped rare earth infrared fluorescent probe and a synthetic method thereof. The fluorescent probe is a nano-crystal in a core-shell structure and includes two parts: a down-conversion luminescent core and an inert shell layer, wherein the down-conversion luminescent core is a neodymium-doped rare earth nano-crystal and is totally coated with the inert shell layer for enhancing a luminescent stability and a luminescent efficiency of the nano-crystal. In the invention, a high-boiling-point solution and a sodium/potassium/lithium/barium trifluoroacetate solution are employed as precursors and a shell-layer precursor solution is introduced at a high temperature in a continuously alternate manner for achieving layer-by-layer coating of the neodymium-doped nano-crystal nucleus. By means of control of the amount of the shell-layer precursor dropwisely added every time, continuous adjustment of thickness of the shell layer is achieved. In the invention, the synthetic method can improve down-conversion luminescent quantum yield and the luminescent stability of neodymium and can reduce a quenching effect of down-conversion luminescence doped by neodymium ions due to environment.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a synthesis method of an efficient anti-quenching neodymium ion-doped rare-earth infrared fluorescent probe. Background technique [0002] In the past ten years, biological imaging has attracted extensive attention of scientific researchers because of its outstanding performance in early diagnosis and treatment of diseases. Among the existing bioimaging techniques, tomographic imaging including CT, PET, MRI, etc. has been widely used because these tomographic imaging are not limited by the penetration depth. However, tomographic imaging has some unavoidable disadvantages, such as limited spatial resolution and inability to observe in real time (because it takes a long time to take pictures, and it often takes several minutes to tens of minutes to obtain a picture). In contrast, optical bioimaging based on the principle of photoluminescence has the a...

Claims

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Application Information

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IPC IPC(8): C09K11/61C09K11/85C09K11/78C09K11/84C09K11/56C09K11/02G01N21/64B82Y30/00B82Y40/00
Inventor 张凡王睿
Owner FUDAN UNIV
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