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Extraction method for achyranthes aspera extract

An extraction method, the technology of Achyranthes bidentata, applied in the field of medicine

Inactive Publication Date: 2015-02-18
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But prepare the medicine for the treatment of alcoholic hepatitis with Achyranthes bidentata or Achyranthes bidentata extract and there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 100g of Achyranthes bidentata medicinal material, crush it, add 15 times the amount of ethanol and ether mixed solution to reflux extraction (the volume ratio of ethanol and ether is 1:9) for 30 minutes, recover ethanol and ether, filter to obtain medicinal residues, add medicinal residues Extract with 10 times water, decoct for 30 minutes, collect the filtrate after filtration, concentrate to a relative density of 1.15 (80°C) at a temperature of 80°C and a vacuum of 0.06MPa, add the same volume of mixed solution of chloroform and n-butanol (The volume ratio of chloroform and n-butanol is 5:1), remove the white flocculent precipitate in the middle, and concentrate the water layer at a temperature of 80°C and a vacuum of 0.06MPa to a relative density of 1.23 (80°C) to obtain the earth cow Knee Extract 21g.

Embodiment 2

[0026] Take 100g of Achyranthes bidentata medicinal material, crush it, add 10 times the amount of ethanol and ether mixed solution to reflux extraction (volume ratio of ethanol and ether is 1:9) for 40 minutes, recover ethanol and ether, filter to obtain medicinal residues, add medicinal residues Extract with 20 times water, decoct for 20 minutes, collect the filtrate after filtration, concentrate to a relative density of 1.12 (80°C) at a temperature of 70°C and a vacuum of 0.06MPa, add the same volume of mixed solution of chloroform and n-butanol (The volume ratio of chloroform and n-butanol is 5:1), remove the white flocculent precipitate in the middle, and concentrate the water layer at a temperature of 80°C and a vacuum of 0.06MPa to a relative density of 1.20 (80°C) to obtain the earth cow Knee Extract 23g.

Embodiment 3

[0028] Take 100g of Achyranthes bidentata medicinal material, crush it, add 30 times the amount of ethanol and ether mixed solution to reflux extraction (the volume ratio of ethanol and ether is 1:9) for 20 minutes, recover ethanol and ether, filter to obtain medicinal residues, add medicinal residues Extract with 40 times water, decoct for 40 minutes, collect the filtrate after filtration, concentrate to a relative density of 1.13 (80°C) at a temperature of 80°C and a vacuum of 0.06MPa, add the same volume of mixed solution of chloroform and n-butanol (The volume ratio of chloroform and n-butanol is 5:1), the white flocculent precipitate in the middle was removed, and the water layer was concentrated to a relative density of 1.22 (80°C) at a temperature of 80°C and a vacuum of 0.04MPa to obtain the soil cow Knee Extract 19g.

[0029] Clinical Trials:

[0030] 1. General Information

[0031] 84 cases were diagnosed according to the diagnostic criteria of alcoholic hepatiti...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to an extraction method for an achyranthes aspera extract. The achyranthes aspera extract obtained through the extraction method can be used for preparing a medicine for treating alcoholic hepatitis. The achyranthes aspera extract provided by the invention can effectively treat alcoholic hepatitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for extracting Achyranthes bidentata extract. Background technique [0002] Alcoholic hepatitis is a liver disease caused by long-term heavy drinking. Severe alcoholism can induce extensive liver cell necrosis and even liver failure. The disease is one of the common liver diseases in our country. Seriously endanger people's health. Alcoholic hepatitis is also a clinical type of alcoholic liver disease. It is a group of clinicopathological syndromes caused by massive necrosis of liver cells in a short period of time. It can occur on the basis of liver cirrhosis with or without liver cirrhosis. The main manifestations are elevated serum ALT and AST and serum total bilirubin were significantly increased, which may be accompanied by fever and elevated neutrophils in peripheral blood. Severe alcoholic hepatitis refers to the manifestations of liver failure in ...

Claims

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Application Information

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IPC IPC(8): A61K36/21A61P1/16
CPCA61K36/21A61K2236/35A61K2236/51A61K2236/53A61K2236/55
Inventor 银胜高王孝勋辛华施学丽辛宁郭敏黄语梦
Owner GUANGXI UNIV OF CHINESE MEDICINE
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