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Application of a kind of Boai capsule as liver transporter inhibitor

Active Publication Date: 2017-11-24
YANGTZE RIVER PHARMA GRP BEIJING HAIYAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex chemical composition and pharmacological effects of traditional Chinese medicine, improper combination of Chinese and Western medicine will also reduce the curative effect, increase side effects or cause drug-induced diseases, serious and even life-threatening, so it is necessary to avoid and prevent drug incompatibility at the same time

Method used

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  • Application of a kind of Boai capsule as liver transporter inhibitor
  • Application of a kind of Boai capsule as liver transporter inhibitor
  • Application of a kind of Boai capsule as liver transporter inhibitor

Examples

Experimental program
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Embodiment Construction

[0019] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0020] The concentration mentioned in this example refers to the concentration in sandwich cultured human hepatocytes or rat hepatocytes.

[0021] Boai Capsules can act as a hepatic transporter inhibitor, which has an effective inhibitory effect on hepatic transporters. The main components of Boai Capsules include the following components in parts by weight:

[0022] Arborvitae leaves 20-30%;

[0023] Rehmannia glutinosa 20-30%;

[0024] Artemisia argyi 20~30%;

[0025] Lotus leaf 20-30%.

[0026] In this example, Boai Capsules produced by Yangzijiang Pharmaceutical Group Co., Ltd. with a batch number of 13080642 were specifically used, and the proportions of the components of the Boai Capsules were within the above-mentioned ranges.

[0027] Liver transporters include uptake transporters responsible for the uptake of exogenous substances...

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Abstract

The invention relates to an application of a cacumen platyclad-folium artemisiae argyi capsule as a liver transporter inhibitor. Particularly, the cacumen platyclad-folium artemisiae argyi capsule plays an inhibiting role on the liver transporter (comprising an uptake transporter and an efflux transporter), so that the cacumen platyclad-folium artemisiae argyi capsule can be combined with western medicines in use for preventing or treating diseases, for example, the cacumen platyclad-folium artemisiae argyi capsule used as the liver transporter inhibitor is combined with irbesartan in use for preventing and treating hypertension.

Description

technical field [0001] The invention relates to the application of Boai capsule as a hepatic transporter inhibitor. Background technique [0002] Transporters are functional membrane proteins located on the cell membrane, and are widely expressed in important organs such as the gastrointestinal tract, liver, blood-brain barrier, and kidney, and directly affect the metabolism of most endogenous substances, exogenous chemical foreign substances, or drugs. Absorption, distribution, metabolism and toxic effects. Among them, the hepatic transporter plays an important role in the hepatobiliary transport of drugs. It takes drugs into the liver, undergoes certain metabolic transformation in the liver, and finally excretes them outside the liver through bile. Among them, the uptake-type hepatic transporters OATP1B1 and OATP1B3 and the efflux-type transporters MRP2 and BSEP have become mandatory experimental items for new drug declarations stipulated by the US FDA and the European EM...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/48A61P9/12A61K31/4184
CPCA61K31/4184A61K36/14A61K36/282A61K36/62A61K36/804A61K2300/00
Inventor 王海盛闫利颖蔡正军龙娜张素行张飞鹏张科之
Owner YANGTZE RIVER PHARMA GRP BEIJING HAIYAN PHARMA
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