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Ghrelin receptor agonists for the treatment of achlorhydria

A prodrug, optical isomer technology, applied in the field of medicine for diseases

Inactive Publication Date: 2015-03-25
RAQUALIA PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been possible to provide a preferred drug for achlorhydria so far

Method used

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  • Ghrelin receptor agonists for the treatment of achlorhydria
  • Ghrelin receptor agonists for the treatment of achlorhydria
  • Ghrelin receptor agonists for the treatment of achlorhydria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0503] Measuring pH in Dog Stomach

[0504] Use male beagles. A metal cannula is surgically inserted on the left side of the abdomen at the very bottom of the gastric tissue region near the greater curvature of the distal stomach. Gastric pH was measured continuously with a flexible pH electrode inserted through the gastric fistula. Vehicle or drug is administered orally to dogs. The results are shown in figure 1 .

Embodiment 2

[0506] By a method similar to that described in Example 1, 3 mg / kg of Compound A was orally administered to dogs. The results are shown in figure 2 . Gastric pH was between 2 and 7 in vehicle-treated conscious dogs. In dogs administered Compound A, the intragastric pH decreased rapidly after administration in both dogs, and the lower pH remained below about 2.5 for more than 3 hours.

Embodiment 3

[0508] Compound B was orally administered to dogs by a method similar to that described in Example 1. The gastric pH in dogs decreased immediately after dosing and remained at a low pH for more than 3 hours.

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PUM

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Abstract

The present invention relates to a use of a compound having ghrelin receptor agonistic activity, a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof for the manufacture of a medicament for treatment of diseases including achlorhydria in which abnormal gastric acid secretion is involved. In addition, the present invention relates to the method of treatment including administering to a human or animal. The compound, the pharmaceutically acceptable salt thereof, or pharmaceutical compositions containing them, may be used in combination with one or more second active agents. Further, the present invention relates to pharmaceutical compositions and kits comprising a compound of the present invention or a pharmaceutically acceptable salt thereof for the treatment of said diseases.

Description

technical field [0001] The present invention relates to the provision of a medicament for increasing gastric acid secretion. In detail, the present invention relates to a compound having agonistic activity on ghrelin receptors or a pharmaceutically acceptable salt thereof, comprising a compound for the treatment of diseases including achlorhydria associated with abnormal secretion of gastric acid. Use of pharmaceutical compositions of said compound or pharmaceutically acceptable salts thereof. The present invention relates to the use of the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or salt together with one or more optional second active agents. [0002] The present invention relates to a method for treating diseases including achlorhydria associated with abnormal gastric acid secretion by administering the compound of the present invention or a composition comprising the same to humans or animals. Backgr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5025A61K31/40A61K31/4045A61K31/4162A61K31/435A61K31/454A61K31/55A61K38/00A61P1/04A61P1/14
CPCA61K31/395A61K31/40A61K31/4045A61K31/4164A61K31/437A61K31/444A61K31/445A61K31/45A61K31/454A61K31/5025A61K38/26A61K45/06A61P1/00A61P1/04A61P1/14A61P43/00A61K2300/00A61K31/4162A61K38/12
Inventor 高桥伸行须藤正树岛田薰若林宏明
Owner RAQUALIA PHARMA INC