A kind of preparation method of cordycepin proliposome

A proliposome and cordycepin technology, applied in the field of medicine, can solve the problem of limiting pharmacological activity such as anti-tumor, achieve the effect of increasing tumor targeting performance, increasing activity, and avoiding degradation
CN104473874BActive Publication Date: 2017-09-12LIAONING UNIVERSITY
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LIAONING UNIVERSITY
Publication Date
2017-09-12

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of cordycepin precursor liposome. The technical scheme adopted is: dissolving lecithin and cholesterol in an appropriate amount of chloroform as the oil phase; the cordycepin phosphate buffer as the water phase; ultrasonically forming an emulsion, placing it on a rotary evaporator to remove the chloroform under reduced pressure, and forming it on the bottle wall colloidal, add an appropriate amount of distilled water, and continue to rotary evaporation to form a cordycepin liposome suspension; add a lactose solution to the cordycepin liposome suspension, pre-freeze at ‑20~‑70°C for 4‑24 hours, and pump Vacuum, continue freeze-drying for 40-60h to obtain cordycepin proliposomes. The cordycepin liposome prepared by the method of the invention is relatively stable, and the results of pharmacokinetic study in rats show that the cordycepin liposome can increase the bioavailability of cordycepin, and has a certain long-acting and slow-release effect in vivo .
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method of cordycepin proliposome. Background technique

[0002] Cordycepin, also known as cordycepin, is a nucleoside alkaloid with the molecular formula C 10 h 13 N 5 o 3 (Molecular structure shown in I), relative molecular weight 251, melting point 231 ℃.

[0003]

[0004] Studies have shown that, as an active ingredient in Cordyceps militaris, cordycepin has a variety of pharmacological effects: such as anti-virus, antibacterial, immune regulation and anti-tumor. It has potential therapeutic effects on many clinical diseases, and has very broad application prospects and markets.

[0005] The anti-tumor effect of cordycepin is more significant. Studies have shown that cordycepin has a significant inhibitory effect on human tissue lymphoma cells U937, Ehrlich ascites tumor cells, leukemia cells HL-60 and human cervical cancer HeLa cells, and has inhibitor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More