Hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent with ultrasound contrast function and preparation method of hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent

A Prussian blue, hollow mesoporous technology, applied in the field of nanomaterial technology and biomedical materials, to achieve the effect of excellent photothermal conversion performance

Active Publication Date: 2015-04-01
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented nanoparticle medicine called HTPB (Human Microbial Protein B) helps improve thermal energy transfer during medical procedures by generating images that show how well they are doing with cancerous tissue. It also allows them to monitor their progress over time through an invisible method like X rays or magnetic resonance techniques. Overall this innovation makes better ways to treat diseases more effectively while minimizing potential harmful health risks associated therewith.

Problems solved by technology

Technologies for developing new types of photoacoustic transducers called nanospongeners have potential applications in various fields such as medicine and healthcare science. They offer promise because they provide better control over cellular processes involved in diseases like malignancy and radiation resistance compared to existing methods. Additionally, they also allow for enhanced photosensitization at specific wavelength regions through laser activation without causing harmful side effects. Overall, these technical advancements make them ideal candidates for future uses in advanced diagnostic techniques.

Method used

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  • Hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent with ultrasound contrast function and preparation method of hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent
  • Hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent with ultrasound contrast function and preparation method of hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent
  • Hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent with ultrasound contrast function and preparation method of hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent

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[0031] The invention relates to an ultrasonic nano-diagnosis and treatment agent based on hollow mesoporous nanoparticles used in ultrasonic imaging and photothermal treatment of tumors and a preparation method thereof. The nano-diagnostic agent is composed of hollow mesoporous nanoparticles formed by a single component with excellent light-to-heat conversion performance as a carrier, loaded with temperature-sensitive PCM. The nano-diagnosis and treatment agent of the present invention is based on HMPB, and is filled with hydrophobic fluorocarbon isothermal-sensitive PCM through a vacuum infusion method.

[0032]The HMPB of the present invention is composed of a single component of Prussian blue, and has excellent photothermal conversion performance (strong absorption in the near-infrared region, high photothermal conversion efficiency and photothermal stability). The highly dispersed, uniform and controllable HMPB nanoparticles have a simple preparation method, low cost of ra...

Embodiment 1

[0055] Weigh 132 mg of potassium iron(III) cyanide and 3 g of polyvinylpyrrolidone K~30 (PVP) in 40 mL of 0.01M hydrochloric acid, stir for 30 min to fully dissolve to form a yellow transparent solution, and place it in an oven at 80 °C for 20 h. Centrifuge at 11000 r / min for 10 min and wash with water once to obtain mesoporous Prussian blue nanoparticles (MPB). MPB was dissolved in 20 mL of 1M hydrochloric acid to disperse uniformly, hydrothermally etched at 140°C for 4 h, centrifuged at 11000 r / min for 10 min, washed once with water to obtain hollow mesoporous Prussian blue (HMPB) and dried for later use. The TEM images of the prepared HMPB before and after etching and the SEM images of HMPB are as follows figure 2 shown;

[0056] Depend on figure 2 In (a), it can be seen that the prepared mesoporous Prussian blue nanocubes have good dispersibility, and the particle size is relatively uniform, ranging from 100 to 500 nm. After etching with 1M hydrochloric acid, a hollow...

Embodiment 2

[0058] Weigh 132 mg of potassium iron (III) cyanide and 3 g of PVP in 40 mL of 0.1 M hydrochloric acid, stir for 30 min to fully dissolve to form a yellow transparent solution, and place it in an oven at 80 °C for 20 h. Centrifuge at 11000r / min for 10min, wash once with water to obtain mesoporous Prussian blue nanoparticles, dissolve in 20mL of 1M hydrochloric acid and disperse uniformly, hydrothermally etch at 140°C for 4h, centrifuge at 11000r / min for 10min, and wash once with water to obtain hollow mesoporous Prussian blue.

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Abstract

The invention relates to a hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent with an ultrasound contrast function, and a preparation method of the hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent. The hollow mesoporous prussian blue nano photo-thermal diagnosis and treatment agent comprises prussian blue nano particles and a thermo-sensitive type phase-change material, wherein the surfaces of the prussian blue nano particles are provided with mesopores; the internal parts of the prussian blue nano particles are hollow; and the thermo-sensitive type phase-change material is loaded in the prussian blue nano particles and comprises a fluorocarbon compound and/or menthol.

Description

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Claims

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Application Information

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Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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