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Non-connection model building method for hypertrophy bone connected with femoral shaft gristle of big mouse

A method of establishing a femoral shaft, which is applied in the field of medical models, can solve problems that affect the accuracy of research conclusions and nonunions that do not meet clinical treatment conditions, and achieve the effects of less trauma, simple operation, and low animal mortality

Active Publication Date: 2015-04-22
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

The design purpose of these methods is only to achieve nonunion, but it does not conform to the clinical treatment situation and the process of nonunion formation. Experimental research with these nonunion models will eventually affect the results of experimental research and research conclusions accuracy

Method used

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  • Non-connection model building method for hypertrophy bone connected with femoral shaft gristle of big mouse
  • Non-connection model building method for hypertrophy bone connected with femoral shaft gristle of big mouse
  • Non-connection model building method for hypertrophy bone connected with femoral shaft gristle of big mouse

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Embodiment Construction

[0035] The method of the present invention will be specifically described below in conjunction with the accompanying drawings and embodiments.

[0036] 1 Materials and methods

[0037] 1.1 Material

[0038] Animals and grouping: 18 healthy male SD rats, weighing 250-300 g, were used in the experiment, provided by Shandong Academy of Medical Sciences. They were randomly divided into 2 groups with 9 rats in each group, namely the experimental group and the control group.

[0039] In the experimental group, a rat femoral external fixator with a fixed stress of 4.5N / mm was used, that is, the low stiffness group; in the control group, a rat femoral external fixator with a fixed stress of 18.6N / mm was used, that is, the high stiffness group.

[0040] Main materials and equipment: The steel needle of the external fixation bracket is made of Italian Orphfix products;

[0041] Titanium alloy screws were purchased from Johnson & Johnson;

[0042] Le...

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Abstract

The invention provides a non-connection model building method for a hypertrophy bone connected with femoral shaft gristle of a big mouse. The method comprises: fixing a support outside the femora of the big mouse; fixing a catagmatic femoral shaft of the big mouse, and obtaining the non-connection model for the hypertrophy bone connected with the femoral shaft gristle of the big mouse. The non-connection model building method for the hypertrophy bone connected with the femoral shaft gristle of the big mouse has the advantages of being simple in operation, small in damage, low in animal mortality, fitting in non-connection clinical characters of the clinical hypertrophy bone, easy in operation, and scientific and reasonable. The non-connection model building method for the hypertrophy bone connected with the femoral shaft gristle of the big mouse has the great significance for the intensive study of the reason of the non-connection development of the hypertrophy bone, and the therapeutic method.

Description

technical field [0001] The invention belongs to the technical field of medical models, and relates to a method for establishing a hypertrophic nonunion model of femoral shaft cartilage connection in rats. Background technique [0002] The ultimate goal of fracture treatment is to heal the fracture and restore normal function to the limb. With the development of the times and science and technology, although the concepts and methods of fracture treatment have made significant progress, nonunion is still a common complication in fracture treatment, and it is also an important factor affecting the achievement of fracture treatment goals. Therefore, how to promote fracture healing and avoid the occurrence of nonunion is an important problem to be solved urgently in orthopedic clinic. [0003] According to the cause of nonunion, X-ray findings and histological characteristics, nonunion is usually divided into hypertrophic nonunion, atrophic nonunion, dystrophic nonunion, inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61B17/60A61B2503/40A61B2503/42A61D1/00
Inventor 张俊忠王瑛罗慧黎立刘效敏
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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