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A kind of porous polyurethane film with gradient pore structure for artificial skin and its preparation method

A polyurethane film, gradient hole technology, applied in medical science, prosthesis and other directions, can solve the problems of difficulty in resisting the invasion of external bacteria, the upper layer of silicone rubber has too large pore size, and cannot be used for a long time, so as to keep the wound moist, excellent mechanical properties, The effect of good water permeability

Active Publication Date: 2016-06-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the artificial skin still has some disadvantages in clinical use: it cannot be used for a long time, has high requirements on the wound surface, and requires secondary skin grafting to cover the wound surface
Although it can give better protection to the wound, it is still not suitable for deep third-degree burns. At the same time, the upper layer of silicone rubber has too large a pore size, which makes it difficult to resist the invasion of external bacteria, and cannot achieve the effect of waterproofing.

Method used

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  • A kind of porous polyurethane film with gradient pore structure for artificial skin and its preparation method
  • A kind of porous polyurethane film with gradient pore structure for artificial skin and its preparation method
  • A kind of porous polyurethane film with gradient pore structure for artificial skin and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Dissolve four parts of 25g of medical-grade polyurethane in 200mL of N,N-dimethylformamide at 60°C, then add 60g, 80g, 100g, and 120g of sodium citrate with a particle size of 75-150μm, and stir mechanically After 1 hour, defoam for 20 minutes at room temperature under a vacuum of 0.06 MPa. The defoamed suspension was evenly poured into a polytetrafluoroethylene mold with a film thickness of 2mm, and then placed in absolute ethanol at 25°C for phase separation and solidified to form a film. The cured polyurethane porous membrane was soaked in deionized water at 25°C for 72 hours to fully filter out the porogen, and the water was changed every 24 hours. The polyurethane porous membrane from which the porogen was removed was dried in a blast oven at 40° C. to obtain a porous polyurethane membrane with a gradient pore structure.

Embodiment 2

[0054] Dissolve 25g of medical-grade polyurethane in 200mL of N,N-dimethylformamide at 60°C, then add 80g of sodium citrate with a particle size of 75-150μm, stir mechanically for 1 hour, and then dissolve it at room temperature under a vacuum of 0.06 Degassing at MPa for 20min. The defoamed suspension was evenly poured into the polytetrafluoroethylene mold for three times, and the film thickness was 1mm each time. After the film was coated, it was put into 25°C absolute ethanol for phase separation, and solidified to form a film. The polyurethane porous membrane cured for the third time was soaked in deionized water at 25°C for 72 hours to fully filter out the porogen, and the water was changed every 24 hours. The polyurethane porous membrane from which the porogen was removed was dried in a blast oven at 40° C. to obtain a porous polyurethane membrane with a gradient pore structure.

Embodiment 3

[0056] Dissolve 10g of medical-grade polyurethane in 200mL of N,N-dimethylformamide at 20°C, then add 10g of sodium citrate with a particle size of 20-75μm, stir mechanically for 1h, and then dissolve it at room temperature under a vacuum of 0.06 Degassing at MPa for 10 minutes. Pour the defoamed suspension evenly into a glass mold with a coating film thickness of 1mm, then put it in absolute ethanol at 20°C for phase separation, and solidify to form a film. The cured polyurethane porous membrane was soaked in deionized water at 5°C for 72 hours to fully filter out the porogen, and the water was changed every 24 hours. The polyurethane porous membrane from which the porogen was removed was dried in a blast oven at 40° C. to obtain a porous polyurethane membrane with a gradient pore structure.

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Abstract

The invention discloses a preparation method of a porous polyurethane film with a gradient porous structure. The preparation method is characterized by comprising the following steps: adding polyurethane into a solvent for dissolving, adding a pore-foaming agent, and mechanically stirring for a period of time to obtain suspension; defoaming the suspension in vacuum, carrying out film casting on a mold, carrying out curing film formation in absolute ethyl alcohol coagulation bath, soaking the film in deionized water to dissolve the pore-foaming agent and completely remove the pore-foaming agent; taking out the film, drying the film in a blast oven to obtain the porous polyurethane film with the gradient porous structure, the upper and lower surfaces of the porous polyurethane film are trim and not curled, and the hand feeling is good. The film can be used as artificial skin and has the advantages of good water and air permeability, high water absorption, excellent mechanical properties, good biological affinity, etc.

Description

[0001] technology field, [0002] The invention relates to a porous polyurethane film with a gradient pore structure for artificial skin and a preparation method thereof, belonging to the technical field of bioengineering materials. Background technique [0003] The skin is the largest organ of the human body and a natural barrier to protect the human body. It plays the role of perception, temperature regulation, secretion, excretion and absorption to the human body, and it is the first line of defense of the human immune system. When the skin is severely traumatized or burned, it may lead to a series of serious problems such as water and electrolyte imbalance, shock, and infection. At this time, autologous skin is urgently needed to cover the wounded surface. However, the source of autologous skin is limited, so it is particularly important to temporarily replace the dermis with an artificial skin that has a certain mechanical strength, toughness, waterproof and breathable, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/56A61L27/18C08J5/18C08J9/26C08J3/11
Inventor 夏和生吴军李志超罗高兴翟天亮赵健徐瑞
Owner SICHUAN UNIV
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