Extraction process of salinomycin

An extraction process, the technology of salinomycin, applied in the field of veterinary drug antibiotic production, can solve the problems of long production cycle and high energy consumption, and achieve the effect of improving production efficiency, reducing production cost and shortening production time

Inactive Publication Date: 2015-04-29
SHANXI XINYUAN HUAKANG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention overcomes the deficiencies of the prior art, and what is to be solved is the problems of long production cycle and high energy consumption in the existing production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of extraction process of salinomycin, comprises the steps:

[0023] 1) Fermentation broth pretreatment

[0024] First, add 3wt.% flocculant to the fermentation broth, stir well, keep it at 30°C for 22 minutes, then add 8wt.% light calcium carbonate and 3wt.% NaHCO 3 Obtain the pretreated fermented liquid after stirring evenly;

[0025] 2) filter

[0026] Filtrating the fermented liquid pretreated in step 1) to obtain a filter cake containing salinomycin;

[0027] 3) Granulation

[0028] The filter cake is extruded and granulated, dried and mixed with auxiliary materials to obtain the finished salinomycin medicine.

Embodiment 2

[0030] A kind of extraction process of salinomycin, comprises the steps:

[0031] 1) Fermentation broth pretreatment

[0032] First, add 2wt.% flocculant to the fermentation broth, stir well, keep it at 35°C for 20 minutes, then add 10wt.% light calcium carbonate and 3wt.% NaHCO 3 Obtain the pretreated fermented liquid after stirring evenly;

[0033] 2) filter

[0034] Filtering the fermented liquid pretreated in step 1) with a plate frame to obtain a filter cake containing salinomycin;

[0035] 3) Granulation

[0036] The filter cake is extruded and granulated, dried and mixed with auxiliary materials to obtain the finished salinomycin medicine.

Embodiment 3

[0038] A kind of extraction process of salinomycin, comprises the steps:

[0039] 1) Fermentation broth pretreatment

[0040] First, add 4wt.% flocculant to the fermentation broth, stir well, keep it at 25°C for 30 minutes, then add 5wt.% light calcium carbonate and 2wt.% NaHCO 3 Obtain the pretreated fermented liquid after stirring evenly;

[0041] 2) filter

[0042] Filtrating the fermented liquid pretreated in step 1) to obtain a filter cake containing salinomycin;

[0043] 3) Granulation

[0044] The filter cake is extruded and granulated, dried and mixed with auxiliary materials to obtain the finished salinomycin medicine.

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PUM

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Abstract

The invention discloses an extraction process of salinomycin, particularly relates to an extraction process of fermented salinomycin, belongs to the technical field of veterinary antibiotics detection, and aims at solving the problems of high production cycle and high energy consumption in an existing production process. According to the technical scheme, the extraction process of salinomycin specifically comprises the following steps: (1) firstly, adding 2-5wt.% of a flocculating agent to a fermentation liquor, stirring evenly, carrying out heat preservation at 250-35 DEG C, standing for 20-30 minutes, adding 5-10wt.% of light calcium carbonate and 2-4wt.% of a filter aid, and stirring evenly to obtain pretreated fermentation liquor; (2) filtering the fermentation liquor pretreated from the step (1), obtaining a filter cake containing salinomycin, and filtering by an optimized sheet frame; and (3) extruding, pelletizing and drying the filter cake, and mixing auxiliary materials, so as to obtain a salinomycin drug product.

Description

technical field [0001] The invention relates to a process for extracting salinomycin, in particular to a process for extracting salinomycin after fermentation, and belongs to the technical field of production of veterinary drug antibiotics. Background technique [0002] Salinomycin is a polyether monocarboxylic acid antibiotic, which can strongly bind to alkali metal ions in cells, especially potassium, sodium, and rubidium ions, and enhance the penetration of cations necessary for biology through the lipid barrier on the cell membrane Sex, inhibit the normal ion balance of sporozoites and schizonts, thereby killing coccidia. Therefore, this product has a high susceptibility to Gram-positive bacteria, fungi, viruses and malaria parasites. As an antiprotozoal drug, it is mainly used for the treatment of poultry coccidiosis, and can also promote the growth of cattle and pigs. [0003] At present, the extraction process of salinomycin after fermentation is mainly as follows: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/351A61P31/04C07D493/20
Inventor 马爱民
Owner SHANXI XINYUAN HUAKANG CHEM
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