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Bioactive hyaluronic acid syrup preparation

A hyaluronic acid and biologically active technology, applied in the direction of non-central analgesics, anti-inflammatory agents, drug combinations, etc., can solve problems such as poor effect and no effective treatment methods, so as to relieve discomfort symptoms and increase human body treatment Effect, effect of increasing biological activity

Inactive Publication Date: 2015-04-29
惠觅宙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cause of many patients may be laryngopharyngeal reflux disease. There is currently no effective treatment for this disease, and long-term use of existing pharyngitis drugs does not work well.

Method used

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  • Bioactive hyaluronic acid syrup preparation
  • Bioactive hyaluronic acid syrup preparation
  • Bioactive hyaluronic acid syrup preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Objective: Production method of bioactive hyaluronic acid fragments.

[0030] Method: The raw material is 200-600KD macromolecular hyaluronic acid with a purity of 90.0%-99.9%, which is cut with recombinant human hyaluronidase PH20 produced by CHO cells, and 1000-2000 units of hyaluronidase is used per gram of hyaluronic acid. Digest at 37 degrees for 4-6 hours, pH5.0-5.5, 130-160mM NaCl, 0.5-1.0mMMgSO 4 , 1.5-2.5mM CaCl 2 , the final molecular weight is 0.7KD-100KD hyaluronic acid fragments.

[0031] At least one end of the hyaluronic acid fragment with a molecular weight of 0.7KD-100KD is the end cleaved by recombinant human hyaluronidase PH20 produced by CHO cells that does not cause allergic reactions in humans, has glycation, and can recognize the normal structure of hyaluronic acid. It has the biological activity of promoting cell secretion of defensin 2, killing microorganisms and inhibiting skin and mucous membrane inflammation. The biological activity depends...

Embodiment 2

[0033] Objective: To study the effect of different syrup formulation excipients on the human biological activity of bioactive hyaluronic acid.

[0034] Method: In this experiment, the method of human experiment was used to detect the biological activity of bioactive hyaluronic acid in human body, that is, the effect of different high-concentration ointment and ointment accessories on the effect of bioactive hyaluronic acid on the treatment of laryngeal and pharyngeal inflammation.

[0035] The pre-experiment on small animals in the early stage of this experiment has found that xanthan gum, modified guar gum, carrageenan, pectin, gelatin, vegetarian meat powder, agar, starch (including collagen, soybean protein hydrolyzate) , yeast protein hydrolyzate) all reduce or do not increase the human biological activity of biologically active hyaluronic acid.

[0036]All cases in this experiment were patients with pharyngitis. Experimental group 1 (sorbitol) took sorbitol 40% + bioactiv...

Embodiment 3

[0049] Bioactive Hyaluronic Acid Low Sugar Syrup

[0050] Formula (percentage by weight): 10% bioactive hyaluronic acid, 40% sorbitol, 1% white sugar, 2% brown sugar, 6.7% maltitol, 0.01% mint flavor, 1% honey, 0.3% sodium benzoate, the balance for water. Namely the formula of Experimental Group 1 of Example 1.

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Abstract

The invention discloses a bioactive hyaluronic acid syrup preparation, which comprises bioactive hyaluronic acid with anti-inflammatory activity, and sorbitol having synergistic effect together with the bioactive hyaluronic acid. The syrup preparation can promote the health of mouth and throat mucosa, and treat syndromes such as cough and the like caused by throat inflammation.

Description

technical field [0001] The invention relates to a biologically active hyaluronic acid syrup preparation. Background technique [0002] Throat and throat diseases often have the characteristics of long course and easy recurrence. Many patients have long-term throat symptoms such as itchy throat, foreign body sensation, throat clearing, and throat burning sensation. In recent years, with the deepening of research, many throat diseases have been found Both are closely related to the reflux of gastric contents to the throat. In 2002, the term laryngopharyngeal reflux disease was officially adopted by the American Academy of Otolaryngology-Head and Neck Surgery. The cause of many patients may be laryngopharyngeal reflux disease. There is no effective treatment for this disease at present, and the long-term use of existing pharyngitis drugs by patients is not effective. [0003] Recent foreign studies have shown that the extracellular matrix macromolecule hyaluronic acid is activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61K31/728A61K9/08A61P29/00
Inventor 惠觅宙
Owner 惠觅宙
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