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A model-making apparatus for animal models of migraine in an awake state

An animal model, awake state technology, used in physical therapy, artificial respiration, internal electrodes, etc., can solve the problems of large amount of dental cement, easy to break, fall off, and easy to fall off of dental cement as a whole, so as to solve the problem of limited use and increased use Contact surface, reproducible results

Inactive Publication Date: 2017-03-15
于生元 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in practice, the repeated use of this model found the following problems: ① Electrode fixation is to lightly attach the energized electrode to the surface of the dura mater and then fix it with dental cement. After repeated use, the dental cement is easy to fall off as a whole. Meningeal contact cannot be guaranteed; ②The amount of dental cement needed to fix the electrodes is large, covering the top of the rat’s head, which affects the healing of the suture and skin; ③The connecting wire between the electrode and the stimulator is a copper wire outer plastic hose, which is easy to break after repeated use , fall off

Method used

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  • A model-making apparatus for animal models of migraine in an awake state
  • A model-making apparatus for animal models of migraine in an awake state

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Experimental program
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Effect test

Embodiment 1

[0012] Experimental animals (rats are used in this application) are anesthetized by intraperitoneal injection of 10% chloral hydrate (0.4ml / 100g), and the hair in the middle of the head is cut off and fixed on a stereotaxic apparatus. Disinfect and incise the skin, fascia and periosteum layer by layer to expose the skull. On the skull, select 4 mm before the intersection of the coronal suture on the cranial midline as the anterior boundary, and 6 mm behind the intersection as the posterior boundary. Two round holes with a diameter of about 1 mm are drilled with a bench-top dental drill, and 4 ° C saline is used to reduce the drill and The temperature of the hole can prevent the dura mater from being burned; after exposing the dura mater of the superior sagittal sinus, place the monopolar electrode connected to the wire interface in the drilled stimulation hole and gently touch the dura mater, but be careful not to scratch the dura mater and Superior sagittal sinus: After the b...

Embodiment 2

[0015] Experimental animals (rats are used in this application) are anesthetized by intraperitoneal injection of 10% chloral hydrate (0.4ml / 100g), and the hair in the middle of the head is cut off and fixed on a stereotaxic apparatus. Disinfect and incise the skin, fascia and periosteum layer by layer to expose the skull. On the skull, select the anterior boundary 4 mm before the coronal suture intersection of the cranial midline, and 6 mm posterior to the intersection point to expose the dura mater of the superior sagittal sinus. Sand the copper wire exposed at the tail of the built-in copper core screw rivet used in this application to remove the outer insulating layer, and then rotate and fix it on the surface of the skull with a rotation depth of about 1-1.5mm so that the copper wire is close to the surface of the dura. It is flat and will not damage the dura mater, so as to achieve the effect of stimulating the meninges. After fixing the two screws and rivets on the surf...

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Abstract

The invention discloses a modeling instrument for a migraine animal model in a clear-headed state. According to the modeling instrument, a method that electric poles are fixed by copper-core-built-in double-screw rivets is adopted, and the electric poles are fixedly arranged on the surface of a skull of an animal directly and are connected with a stimulator, so that the firmness of the electric poles and the feasibility of reuse of the animal model are improved, the operation is simplified compared with that in the prior art, and the reliability of contact between the electric poles and dura mater of brain is improved.

Description

technical field [0001] The invention relates to an instrument, which can be used for modeling migraine animal models in an awake state. Background technique [0002] Migraine is a primary headache with unknown pathogenesis. The main theories are vascular origin theory, trigeminal neurovascular theory and cortical spreading inhibition theory. At present, the animal models of migraine mainly include: the model of vascular origin, which takes isolated and in vivo intracranial blood vessels as the research object, and mainly studies the pharmacokinetics of migraine drugs; the model of cortical spreading inhibition, which focuses on The electrical activity of cortical neurons is related to migraine aura; the gene correlation model is used to explore the pathogenesis of familial migraine from the aspect of genetics; the trigeminal nerve vascular reflex model is successfully modeled by the activation of trigeminal spinal nucleus neurons According to the modeling method, it can be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/36A61N1/05
Inventor 于生元王晓琳董钊刘若卓
Owner 于生元