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Plant polysaccharide protective washing solution

A plant polysaccharide and washing liquid technology, applied in the field of medicine, can solve the problems of not examining the hemostatic function of the washing liquid, but only considering the surgical washing and anti-adhesion functions of the sodium carboxymethyl cellulose washing liquid, so as to protect biological activity and inhibit bacteria. Growth, non-degradable effect

Inactive Publication Date: 2015-06-24
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above three patents only considered the surgical flushing and anti-adhesion functions of carboxymethylcellulose sodium irrigation solution, and did not investigate the hemostatic function of irrigation solution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~3

[0029] Weigh 0.07g of disodium hydrogen phosphate and 0.03g of potassium dihydrogen phosphate, add 100ml of normal saline, stir to dissolve, and steam sterilize at 121°C for 30min; Dissolve the sodium cellulose in the above solution, measure the pH, filter, fill the filtrate, fill it with nitrogen, and seal it.

[0030] Table 1 Formula of calcium modified sodium carboxymethyl cellulose

[0031] .

Embodiment 4~10

[0033] Preparation example of further adding glycerin and thiourea: Weigh 0.07g of disodium hydrogen phosphate, 0.03g of potassium dihydrogen phosphate, glycerin and thiourea in the formula, add 100ml of normal saline, stir to dissolve, and steam sterilize at 121°C for 30min; Under a sterile environment, dissolve 1 g of sterilized calcium-modified sodium carboxymethylcellulose (calcium content 2.5%, degree of substitution 0.65) in the above solution, measure pH, filter, fill the filtrate, fill with nitrogen, and seal , to obtain final product; the addition amount of glycerol and thiourea is shown in Table 2.

[0034] Table 2 The amount of glycerin and thiourea added

[0035] .

preparation example

[0037] Preparation example for adjusting the amount of buffer substance added: Weigh disodium hydrogen phosphate, potassium dihydrogen phosphate, 1.5 g glycerin and 5 mg thiourea, add 100 ml of normal saline, stir to dissolve, and steam sterilize at 121 ° C for 30 minutes; In a bacterial environment, dissolve 1 g of sterilized calcium-modified sodium carboxymethyl cellulose (calcium content 2.5%, substitution degree 0.65) in the above solution, measure pH, filter, fill the filtrate, fill with nitrogen, seal, That is obtained; the addition amount of disodium hydrogen phosphate and potassium dihydrogen phosphate is shown in Table 3.

[0038] Table 3 The amount of buffer substances added

[0039] .

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Abstract

The invention relates to a plant polysaccharide protective washing solution taking calcium-modified sodium carboxymethylcellulose as a main component. The plant polysaccharide protective washing solution comprises the following components: 0.3%-3% by weight of calcium-modified sodium carboxymethylcellulose, and 0.01%-0.1% by weight of a pH buffer substance and physiological saline, wherein the pH value of the plant polysaccharide protective washing solution is 6.5-7.5. The plant polysaccharide protective washing solution provided by the invention has the effects of performing surgical flushing, preventing adhesion and promoting wound healing, simultaneously has a hemostatic function and is good in stability and difficult to degrade.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a plant polysaccharide protective flushing liquid used for trauma and surgical flushing. Background technique [0002] Before treating various wounds, the wounds should be rinsed to avoid wound infection. The function of the currently used irrigating fluid is relatively single, which only rinses the wound surface and removes necrotic tissue fragments, foreign objects and bacteria. For example, adding coagulation factors to the flushing solution can speed up the process of hemostasis, which will have very important clinical significance. [0003] Carboxymethylcellulose sodium has the advantages of good bacteriostasis and water solubility, and its aqueous solution has a lubricating function. It is clinically used as a flushing solution for surgical flushing and wound cleaning to prevent surgical adhesions. [0004] The patent application number 200610042240.3 disclose...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K33/14A61K31/717A61K31/19A61K47/04A61K47/20A61P17/02A61P7/04A61P41/00A61P31/02A61K31/045
Inventor 董科李素哲王聪卓刘俊英刘媞李璟
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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