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Pharmaceutical composition for treating endometriosis (EMT) and adenomyosis (AM) and preparation method and use thereof

A technology for adenomyosis and endometrium, which is applied in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of unacceptable genital removal patients, inappropriate fertility requirements, and high treatment costs. , to achieve the effect of convenient clinical application, clear efficacy, and improved clinical efficacy

Inactive Publication Date: 2015-07-01
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The treatment of EMT and AM is still very difficult. Western medicine mainly uses surgery and hormonal drug therapy. Although hysterectomy can achieve the goal of radically curing dysmenorrhea and menorrhagia, it is difficult for some patients to accept reproductive organ removal, especially for young people who want to have children. Inappropriate
Although western medicine hormonal drug treatment can make dysmenorrhea disappear, menstrual volume decrease, endometrium atrophy, uterus shrink, but the treatment cost is high, and there are side effects such as low estrogen symptoms, osteoporosis, liver function damage, etc. There is still a high recurrence rate

Method used

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  • Pharmaceutical composition for treating endometriosis (EMT) and adenomyosis (AM) and preparation method and use thereof
  • Pharmaceutical composition for treating endometriosis (EMT) and adenomyosis (AM) and preparation method and use thereof
  • Pharmaceutical composition for treating endometriosis (EMT) and adenomyosis (AM) and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of pharmaceutical tablet of the present invention

[0022] Prescription composition: Daxueteng 100g, Banzhilian 100g, rhubarb (wine-roasted) 50g, peach kernel 50g, wood beetle 50g, leech 50g, trigonum 75g, curcuma 75g, turtle shell 75g, oyster 100g, Fritillaria 75g, coix Jen 100g.

[0023] Preparation method: the above twelve flavors, 37.5g of leeches, curcuma, and fritillary fritillaria are crushed into fine powder, sieved, mixed, and set aside. Add the remaining nine flavors such as Fritillaria fritillaria and the rest of Daxueteng and other nine flavors to decoct three times, add 5 times the amount of water for the first time, and decoct for 1 hour. Add 3 times the amount of water for the second and third times, decoct for 40 minutes, combine the decoction, filter, and concentrate the filtrate into a thick paste with a relative density of 1.30-1.40 (80°C), add the above fine powder, 35g of starch, and sucrose powder 65g, mixed, granulated, ...

Embodiment 2

[0026] Embodiment 2 Preparation of pharmaceutical capsules of the present invention

[0027] Take the prescription raw materials: Daxueteng 80g, Banzhilian 80g, rhubarb 40g, peach kernel 40g, wood beetle 40g, leech 40g, trigonum 60g, curcuma 60g, turtle shell 60g, oyster 80g, Zhejiang Fritillaria 60g, coix seed 80g ; According to the method described in Example 1, granulate and pack into capsules to obtain capsules.

Embodiment 3

[0028] Embodiment 3 The preparation of medicinal powder of the present invention

[0029] 120g Daxueteng, 120g Scutellaria barbata, 60g rhubarb, 60g peach kernel, 60g wood beetle, 60g leech, 90g trigonum, 90g curcuma, 90g turtle shell, 120g oyster, 90g fritillaria, 120g coix seed, powdered and sieved directly , prepared into a powder.

[0030] Prove the beneficial effect of the present invention by specific pharmacodynamic test or clinical test below.

[0031] Control drug:

[0032] Danazol Capsules (positive control drug of Western medicine in this experiment): it is a synthetic 17α-ethynyl testosterone derivative, which has weak androgenic activity, but no progestin and estrogen activity, can inhibit the secretion of Gn-RH, and directly inhibit steroid hormones synthesis, directly inhibits and competes with estrogen and progesterone receptors in the endometrium. It is mainly used clinically for the treatment of EMT. 100mg / tablet, calculated according to the adult daily d...

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Abstract

The invention provides a pharmaceutical composition for treating endometriosis (EMT) and adenomyosis (AM). The pharmaceutical composition is a preparation prepared from the following raw pharmaceutical materials in parts by weight: 80-120 parts of sargentgloryvine stem, 80-120 parts of barbat skullcap, 40-60 parts of rhubarb root, 40-60 parts of peach kernels, 40-60 parts of ground beetle, 40-60 parts of leeches, 60-90 parts of rhizoma sparganii, 60-90 parts of zedoary, 60-90 parts of turtle shell, 80-120 parts of oyster shell, 60-90 parts of Zhejiang fritillary bulb and 80-120 parts of coix seed. The invention further provides a preparation method and use of the pharmaceutical composition. Drugs prepared from the pharmaceutical composition are used for treating EMT and AM, are definite in drug effect and have the advantages of stable quality, convenience in carrying, easiness in storage and convenience in batch production compared with traditional Chinese medicine decoctions; clinical application is better facilitated, the tolerability and acceptability to the drugs of patients are improved, difficult problems in the treatment of EMT and AM by using the decoctions at present are solved, the clinical treatment effect is further improved, professional special-disease traditional Chinese medicine treatment characteristics are strengthened, and a new option is provided for the clinical treatment of EMT and AM.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating endometriosis and adenomyosis. Background technique [0002] Endometriosis (EMT) and adenomyosis (adenomyosis, AM) are difficult gynecological diseases, mainly manifested as pelvic pain, dysmenorrhea, infertility, abnormal menstruation, etc., seriously affecting women's health and quality of life. Because of its complex pathogenesis, extensive lesions, and malignant biological behavior of infiltration and recurrence, it has become a hot and difficult issue in basic and clinical research in gynecology. [0003] Traditional Chinese medicine has no records of the names of "endometriosis" and "adenomyosis", but according to their clinical manifestations and characteristics, they belong to the motherland's medicine "dysmenorrhea", "abdominal mass", "infertility", " Irregular menstruation" and other disease categories. According to the clinical characteristics and pathological mechanism of ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P15/00A61K35/62A61K35/64A61K35/618A61K35/586
Inventor 魏绍斌王妍季晓黎石玲胡云华杨成成
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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