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A composition with the function of activating hsf‑1 transcription and its use

A technology of HSF-1 and composition, which can be applied to medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve the problems such as cell senescence and death that have not been seen

Inactive Publication Date: 2017-09-12
赵伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such factors have not yet been developed but have promising targets, but at present, there is no application of regulating HSF1 and its encoded HSPs to prevent or delay cell aging and death at home and abroad

Method used

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  • A composition with the function of activating hsf‑1 transcription and its use
  • A composition with the function of activating hsf‑1 transcription and its use
  • A composition with the function of activating hsf‑1 transcription and its use

Examples

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Effect test

Embodiment 1

[0025] Embodiment 1: An embodiment of the composition of the present invention having the function of activating HSF-1 transcription

[0026] The composition is a mixture of resveratrol, β-hydroxymethyl butyrate, 3,4-dichloroisocoumarin and polyinosinic acid cytosine nucleotides, and the dosage of the resveratrol is 0.035 parts by weight, the consumption of the β-hydroxymethyl butyrate is 0.200 parts by weight, the consumption of 3,4-dichloroisocoumarin is 0.010 parts by weight, and the consumption of polyinosinic acid cytosine nucleotides is 0.020 parts by weight. The composition can be obtained by mixing the above materials according to the above weight parts, and the composition here is called composition A.

Embodiment 2

[0027] Embodiment 2: An embodiment of the composition with the function of activating HSF-1 transcription according to the present invention

[0028] The composition is a mixture of resveratrol, β-hydroxymethyl butyrate, 3,4-dichloroisocoumarin and polyinosinic acid cytosine nucleotides, and the dosage of the resveratrol is 0.500 parts by weight, the consumption of the β-hydroxymethyl butyrate is 3.000 parts by weight, the consumption of 3,4-dichloroisocoumarin is 0.200 parts by weight, and the consumption of polyinosinic acid cytosine nucleotides is 0.050 parts by weight. The composition can be obtained by mixing the above materials according to the above weight parts, and the composition here is called composition A.

Embodiment 3

[0029] Embodiment 3: An embodiment of the composition having the function of activating HSF-1 transcription according to the present invention

[0030] The composition is a mixture of resveratrol, β-hydroxymethyl butyrate, 3,4-dichloroisocoumarin and polyinosinic acid cytosine nucleotides, and the dosage of the resveratrol is 0.20 parts by weight, the consumption of the β-hydroxymethyl butyrate is 1.00 parts by weight, the consumption of 3,4-dichloroisocoumarin is 0.10 parts by weight, and the consumption of polyinosinic acid cytosine nucleotides is 0.03 parts by weight. The composition can be obtained by mixing the above materials according to the above weight parts, and the composition here is called composition A.

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Abstract

The invention provides a composition with the function of activating HSF-1 transcription. The composition with the function of activating HSF-1 transcription can induce the increase of in vivo HSF-1 activity, the increase of in vivo HSF-1 activity can conduct competition and synergy of a transcription enhancer NF-kappa B, so as to specifically increase the activity of adenyl cyclase, Sirt1 and Sirt3, and assist protein folding and protective properties collaboratively with HSPs, and activate anti-aging enzyme pathway. The important part of the invention is that the HSF-1 and the heat shock protein HSPs, the transcription of which is completed by HSF-1, closely involve in the expression and activity regulation of the anti-ageing enzyme. The process by activating the in vivo stress effect factor specifically activates the antioxidant and anti-apoptosis pathway, thereby achieveing the purpose of anti-aging. Therefore, the invention provides a novel target for the activation of the anti-aging enzyme pathway, and provides an effective regulator for the aging regulation and control of cells at the gene level.

Description

technical field [0001] The invention relates to a composition, in particular to a composition with the function of activating HSF-1 transcription and its use. Background technique [0002] Stress is the response of cells to various unfavorable factors in the living environment. Temperature changes, protein misfolding, oxidative damage, and virus invasion can all cause cell stress. It changes the homeostasis of the body and initiates corresponding signal transduction. pathways, giving rise to a cascade of molecular events that have broad and profound effects. One of the typical characteristics of stress response is the activation of cellular heat shock factor (heat shock factor, HSF), and then the expression of one or several heat shock proteins (heat shock protein, HSP). Heat shock transcription factors are a class of highly conserved proteins that play important roles in cell growth, development, stress response and disease progression. In the human genome, four heat shoc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K8/34A61K8/37A61K8/49A61K8/44A61K8/64A61K31/22A61K31/366A61K31/343A61K31/787A23L33/00A61P39/06A61Q19/08A61K31/192
Inventor 赵伟李波
Owner 赵伟
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