A kind of fermentation-separation coupling prepares the method for lactic acid and/or lactate

A technology of lactic acid and magnesium lactate, applied in chemical instruments and methods, preparation of organic compounds, separation/purification of carboxylic acid compounds, etc., can solve problems such as low yield and long lactic acid cycle, and achieve cost reduction, pollution reduction, Good economic and social benefits

Active Publication Date: 2018-01-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems of long period and low yield of lactic acid produced by fermentation of starch hydrolyzate, the present invention uses starch as fermentation raw material and magnesium salt as neutralizer to ferment and produce lactic acid, and uses fermentation-separation coupling technology to separate and purify lactic acid or lactic acid Salt, substantially free of any solid or liquid waste discharge, providing an environmentally friendly method of producing lactic acid or lactate

Method used

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  • A kind of fermentation-separation coupling prepares the method for lactic acid and/or lactate

Examples

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Effect test

Embodiment 1

[0033] 2L of defatted rice bran hydrolyzate is used as a medium, 15g / L rice bran protein hydrolyzate is used as a nitrogen source, inoculated with 10% Lactobacillus rhamnosus, the temperature is 42°C, the speed is 280rpm, 20% magnesium oxide is used as a neutralizer, and the pH is controlled at 6.2- 6.25 After a fermentation period of 60 hours, a magnesium salt fermentation liquid with a lactic acid content of 156 g / L was obtained. The first batch of fermented liquid was left to settle at room temperature for 2 hours, and the crystallization rate of magnesium lactate was 50%, and the supernatant was returned to the fermenter for the second batch of fermentation; the lactic acid content of the second batch of fermented liquid reached 140g / L, and the crystallization rate was 48%; The third batch of fermentation reached 140g / L, and the crystallization rate was 47%; this cycle continued until the productivity decreased significantly.

[0034] Magnesium lactate crystals were washed...

Embodiment 2

[0036] Magnesium salt fermented liquid as described in embodiment 1.

[0037] Magnesium lactate crystals were washed with water at 4°C to remove soluble impurities to obtain crude magnesium lactate; redissolved in distilled water to 100g / L, removed impurities with an ultrafiltration membrane with a molecular weight cut-off of 6KDa, evaporated and recrystallized at 70°C and 0.09MPa , The crystals were dried at 0.9MPa, 50°C for 3h, and the finished product of magnesium lactate with a purity of 96% was obtained. The recrystallization supernatant was adjusted to pH 2.5 with sulfuric acid; the acid hydrolysis feed solution was decolorized and impurity-removed with an ultrafiltration membrane with a molecular weight cut-off of 3KDa; the ultrafiltration feed solution was removed with Dow NF270 at 1.0 MPa and 40°C to remove multivalent ions and small molecular impurities ; The nanofiltration permeate liquid is concentrated at 70°C into a finished product of lactic acid with a purity o...

Embodiment 3

[0039] Magnesium salt fermented liquid as described in embodiment 1.

[0040]Magnesium lactate crystals were washed with water at 0°C to remove soluble impurities to obtain crude magnesium lactate; redissolved in distilled water to 60g / L; adjusted to pH 2.3 with sulfuric acid; impurity was removed by an ultrafiltration membrane with a molecular weight cut-off of 3KDa; Use Dow NF270 at 0.8 MPa and 50°C to remove multivalent ions and small molecular impurities; the nanofiltration permeate liquid is concentrated at 70°C to produce lactic acid with a purity of 85%. Magnesium sulfate in the nanofiltration retentate is crystallized to obtain magnesium sulfate with a purity of 96%. .

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Abstract

The invention relates to a method for preparing a lactic acid and / or lactate through fermentation-separation coupling. According to the method, starch is used as fermenting materials; magnesium salt is used as a neutralizing agent for fermentation production of the lactic acid; the fermentation-separation coupling technique is utilized for separation and purification so as to obtain the lactic acid or lactate. Substantially, no solid or liquid waste is discharged, so that the method is friendly to the environment.

Description

technical field [0001] The invention relates to a method for preparing lactic acid and / or lactate through fermentation-separation coupling, and belongs to the field of biotechnology. Background technique [0002] Lactic acid (LA) is one of the three recognized organic acids in the world and is widely used in food, brewing, medicine, leather, cigarette, chemical and printing and dyeing industries. Recently, it has also been found that the polymer of lactic acid is biodegradable, and its application can be extended to medicine, plastics and other fields, and its application value is increasingly valued by people. [0003] Magnesium lactate, white to cream-colored crystal powder or granular, odorless. Soluble in hot water, widely used in food, beverage, dairy products, flour, nutrient solution and pharmaceuticals. Magnesium lactate is an excellent and economical magnesium organic fortifier. It is widely added to various foods to supplement the lack of magnesium in food. It ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/56C07C51/41C07C51/42C07C59/08
CPCC07C51/412C07C51/42C12P7/56C07C59/08
Inventor 谭天伟贺美玲王勇秦培勇吕永琴
Owner BEIJING UNIV OF CHEM TECH
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