Preservative composition with anti-acne function

A technology of composition and antiseptic, which is applied in the direction of detergent composition, drug combination, detergent compounding agent, etc., to achieve the effect of reducing the amount of use, small amount of use, and improving the safety of use

Inactive Publication Date: 2015-07-29
BEIJING SUNPU BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing patents focus on the anti-acne effect of the mixture of several or more plants, and explain their preparation methods, and few have the inhibitory effect and oil control effect on Propionibacterium acnes and other common bacteria that are the root cause of acne. show

Method used

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  • Preservative composition with anti-acne function
  • Preservative composition with anti-acne function
  • Preservative composition with anti-acne function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Table 1. Natural plant preservative composition each formula charging amount (weight %)

[0032]

[0033]

[0034] Preparation method: add plant efficacy additives, preservatives, and synergists to the above-mentioned formula solvent in sequence, and stir evenly to obtain a stable anti-acne preservative composition.

Embodiment 2

[0036] Antibacterial (inhibition) test - Determination of the antibacterial ring of preservatives (Oxford cup method).

[0037] Refer to "Technical Specifications for Disinfection (2002 Edition)" in "Technical Specifications for Disinfection Products Inspection No. 2.1.8.2 Antibacterial Ring Test", USP35-Antimicrobial Effectiveness Testing, "Hygienic Specifications for Cosmetics (2007 Edition)" "4th Some microbiological test methods".

[0038] 1. Test strains: Escherichia coli, Staphylococcus aureus, Candida albicans, Staphylococcus, Propionibacterium acnes.

[0039] 2. Test samples: 1#-4# preservative compositions in Example 1, the use concentration is 0.5%, and 40% 1,2-propanediol is used as the blank control.

[0040] 3. Judgment of antibacterial effect: If the diameter of the antibacterial ring is greater than 7mm, it is judged to have antibacterial effect. If the diameter of the antibacterial ring is less than or equal to 7mm, it is judged as having no antibacterial eff...

Embodiment 3

[0045] Antibacterial (inhibitory) test - minimum inhibitory concentration (MIC value)

[0046] The minimum inhibitory concentration (MIC value) of each formula preservative composition was determined by the suspension method, and the results are shown in Table 3.

[0047] Table 3 Determination of minimum inhibitory concentration of preservatives (MIC value)

[0048]

[0049] In Table 3, compared with 1# and 3#, when the content of other ingredients is the same, and the plant extract and synergist are added, the MIC values ​​against Propionibacterium acnes and Staphylococcus epidermidis have decreased, that is, it contains plant ingredients The antibacterial performance of the sample and the synergist has been enhanced; 2# is compared with 6#, the total amount of parabens contained in the formula of 6# is higher than that of 2#, but the MIC values ​​of the two are almost the same, indicating that the antibacterial effect is the same In some cases, adding plant extracts can re...

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Abstract

The invention provides a preservative composition containing various plant anti-acne components. The usage amount of the preservative can be reduced by sufficiently bringing the synergistic antibacterial effect of each component in the composition into play; the preservative composition has broad-spectrum bacteriostasis, is easy to use, safe and effective, harmless to a human body, and can be used for microbial sterilization and corrosion prevention in products of personal care, functional cosmetics, cosmeceuticals and the like; a natural plant preservative raw material is natural, safe, non-toxic, environment-friendly, and harmless to the human body, the used synergetic effect additive and solvent are alcohols, and the three achieve synergistic interaction, so that the preservative composition especially has a good inhibitory effect on propionibacterium acnes and staphylococcus epidermidis.

Description

technical field [0001] The invention relates to a preservative composition containing various natural plant anti-acne ingredients and a synergist, which is mainly used for antiseptic and sterilization of microorganisms in personal care products, functional cosmetics, cosmeceuticals and other products. Background technique [0002] Acne (Acne), also known as acne, is a chronic inflammatory disease of the pilosebaceous glands. According to clinical manifestations, it can be divided into punctate acne, papular acne, pustular acne, and nodular acne. Western medicine treatment mainly adopts oral administration and external application of antibiotics to reduce inflammation and suppress seborrhea. Traditional Chinese medicine believes that the formation of acne is mostly caused by wind-heat in the lung meridian, fumigation of the skin; or excessive consumption of spicy and greasy things, accumulation of damp and heat in the spleen and stomach, eroding the skin, or due to imbalance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/34A61Q19/00A61Q11/00A61Q5/02A61P17/10A61P31/04C11D3/48C11D3/382
Inventor 张慧明杨燕冯士清于跃裴双秀
Owner BEIJING SUNPU BIOCHEM TECH
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