Method for determining contents of ginsenosides Rg1 and Re in Xinnaoning tablet

A ginsenoside and determination method technology, applied in the field of medical analysis, can solve the problems of poor separation, high cost, long time consumption, etc., and achieve the effects of high recovery rate, high precision and good stability

Inactive Publication Date: 2015-07-29
NO 371 HOSPITAL PLA
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  • Abstract
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Problems solved by technology

[0006] One of the purposes of the present invention is to aim at the active ingredient ginsenoside Rg in the center naoning tablet of the prior art 1 The separation degree of the quantitative determination method of Re and Re is poor, need detect respectively and detect and detect t

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  • Method for determining contents of ginsenosides Rg1 and Re in Xinnaoning tablet
  • Method for determining contents of ginsenosides Rg1 and Re in Xinnaoning tablet
  • Method for determining contents of ginsenosides Rg1 and Re in Xinnaoning tablet

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Embodiment 1

[0021] 1. Prescription

[0022] Ginseng 250g

[0023] Chuanxiong 500g

[0024] Angelica 500g

[0025] Astragalus 500g

[0026] 2. Preparation method

[0027] Take 120g each of ginseng and astragalus, and crush them into 100-mesh fine powder for later use; take Chuanxiong, angelica and the remaining ginseng and astragalus, powder them into 10-mesh coarse powder, add water to decoct twice, and the amount of water used is 8 times the weight of the medicinal materials. The decoction time is 2 hours / time, filter, combine the secondary filtrate, and concentrate to form a thick paste with a relative density of 1.15-1.30 and a mass of 3kg at 80°C; take the above thick paste, add the above fine powder and appropriate amount of starch Mix well, dry into a dry paste, pulverize, granulate with dilute syrup through a 14-16 mesh sieve, dry at 50-60°C, granulate with a 14-mesh sieve, add 1% magnesium stearate, mix evenly, and press into tablets , coated, and made into 1000 tablets.

[...

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Abstract

The invention belongs to the technical field of medical analysis and particularly relates to a method for determining the contents of ginsenosides Rg1 and Re in a Xinnaoning tablet. According to the method, the technical difficult problems that active pharmaceutical ingredients of the Xinnaoning tablet are difficult to separate, and the contents of the ginsenosides Rg1 and Re in the Xinnaoning tablet cannot be simultaneously determined by adopting a high performance liquid chromatography method, which are always expected to be solved by people but still are not solved, are solved. By using the provided gradient elution high performance liquid chromatography method, the ginsenosides Rg1 and Re are successfully separated from other peaks. The method disclosed by the invention has the advantages of simplicity and convenience in operation, lower cost and shorter detection time, and can be used as a standard quantitative determination method in the drug standard of the Xinnaoning tablets.

Description

technical field [0001] The invention belongs to the technical field of medical analysis, in particular to a kind of ginsenoside Rg in Xinnaoning Tablets 1 And the determination method of Re content. Background technique [0002] Xinnaoning Tablet is a new type of drug for the treatment of ischemic stroke, which is formulated according to the principle of treating both symptoms and root causes. It is made from ginseng, angelica, chuanxiong, and astragalus. Among them, ginsenoside Rg 1 , Re is the main active ingredient of ginseng in the prescription, in order to control the quality of the drug and ensure the curative effect, the ginsenoside Rg in the prescription is required 1 , Re is measured to ensure that its content is within the specified range. [0003] In the prior art, high performance liquid chromatography (HPLC) is usually used to measure ginsenoside Rg in Xinnaoning Tablets. 1 , Re content. However, the composition of compounds in Chinese medicinal materials ...

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Application Information

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IPC IPC(8): G01N30/02
Inventor 申晋昌谢国旗郝少君苏峰王同渠王希东张正臣
Owner NO 371 HOSPITAL PLA
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