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Treatment of cancer with pomalidomide in a renally impaired subject

A technology of pomalidomide and subjects, which can be applied to medical preparations containing active ingredients, applications, and resistance to vector-borne diseases, etc., can solve the problem of prolonging the duration of anti-tumor drugs, increasing the toxicity of anti-tumor drugs, and reducing drug Problems such as the speed of elimination

Inactive Publication Date: 2015-09-09
CELGENE CORP
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, impaired renal function reduces the rate of drug elimination, may inadvertently prolong the duration of exposure to antineoplastic agents, and may subsequently increase the toxicity of these antineoplastic agents

Method used

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  • Treatment of cancer with pomalidomide in a renally impaired subject
  • Treatment of cancer with pomalidomide in a renally impaired subject
  • Treatment of cancer with pomalidomide in a renally impaired subject

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Embodiment Construction

[0061] 5.1 Definition

[0062] Generally, the nomenclature used herein and the experimental procedures in medicinal chemistry, biochemistry, biology, and pharmacology described herein are those well known and commonly used in the art. Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

[0063] The term "subject" refers to animals including, but not limited to, primates (eg, humans), cows, pigs, sheep, goats, horses, dogs, cats, rabbits, rats, and mice. The terms "subject" and "patient" are used interchangeably herein when referring to, for example, a mammalian subject such as a human subject, in one embodiment a human.

[0064] The term "treating" includes alleviating or eliminating the disorder, disease, or condition, or one or more symptoms associated with the disorder, disease, or condition; or alleviating or eradicating the cau...

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Abstract

Provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a subject with renal impairment, comprising administering to the subject pomalidomide. Also provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a subject with renal impairment, comprising administering to the subject a therapeutically effective amount of pomalidomide and dexamethasone.

Description

[0001] 1. References to related applications [0002] This application claims priority to U.S. Provisional Application Serial No. 61 / 722,722, filed November 5, 2012, and U.S. Provisional Application Serial No. 61 / 764,466, filed February 13, 2013; the disclosure of each is incorporated by reference in its entirety into this article. 2. Technical field [0003] Provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (eg, cancer) in a renally impaired subject comprising administering pomalidomide to the subject. Also provided herein is a method of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a renally impaired subject comprising administering to the subject a therapeutically effective amount of pomalidomide and dexamethasone . 3. Background technology [0004] 3.1 Cancer Pathology [0005] Cancer is primarily characterized by an increase in the number of abnormal cells from a given normal tis...

Claims

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Application Information

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IPC IPC(8): A01N43/40A61K31/445
CPCA61K31/454A61K31/573A61P35/00A61P35/02A61P43/00Y02A50/30A61K2300/00
Inventor 克劳迪娅·伊芙·卡塞拉
Owner CELGENE CORP
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