Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Treatment of cancer with pomalidomide in a renally impaired subject

A technology of pomalidomide and subjects, which can be applied to medical preparations containing active ingredients, applications, and resistance to vector-borne diseases, etc., can solve the problem of prolonging the duration of anti-tumor drugs, increasing the toxicity of anti-tumor drugs, and reducing drug Problems such as the speed of elimination

Inactive Publication Date: 2015-09-09
CELGENE CORP
View PDF33 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, impaired renal function reduces the rate of drug elimination, may inadvertently prolong the duration of exposure to antineoplastic agents, and may subsequently increase the toxicity of these antineoplastic agents

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Treatment of cancer with pomalidomide in a renally impaired subject
  • Treatment of cancer with pomalidomide in a renally impaired subject
  • Treatment of cancer with pomalidomide in a renally impaired subject

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0061] 5.1 Definition

[0062] Generally, the nomenclature used herein and the experimental procedures in medicinal chemistry, biochemistry, biology, and pharmacology described herein are those well known and commonly used in the art. Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

[0063] The term "subject" refers to animals including, but not limited to, primates (eg, humans), cows, pigs, sheep, goats, horses, dogs, cats, rabbits, rats, and mice. The terms "subject" and "patient" are used interchangeably herein when referring to, for example, a mammalian subject such as a human subject, in one embodiment a human.

[0064] The term "treating" includes alleviating or eliminating the disorder, disease, or condition, or one or more symptoms associated with the disorder, disease, or condition; or alleviating or eradicating the cau...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a subject with renal impairment, comprising administering to the subject pomalidomide. Also provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a subject with renal impairment, comprising administering to the subject a therapeutically effective amount of pomalidomide and dexamethasone.

Description

[0001] 1. References to related applications [0002] This application claims priority to U.S. Provisional Application Serial No. 61 / 722,722, filed November 5, 2012, and U.S. Provisional Application Serial No. 61 / 764,466, filed February 13, 2013; the disclosure of each is incorporated by reference in its entirety into this article. 2. Technical field [0003] Provided herein are methods of treating, preventing, or managing one or more symptoms of a disease (eg, cancer) in a renally impaired subject comprising administering pomalidomide to the subject. Also provided herein is a method of treating, preventing, or managing one or more symptoms of a disease (e.g., cancer) in a renally impaired subject comprising administering to the subject a therapeutically effective amount of pomalidomide and dexamethasone . 3. Background technology [0004] 3.1 Cancer Pathology [0005] Cancer is primarily characterized by an increase in the number of abnormal cells from a given normal tis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01N43/40A61K31/445
CPCA61K31/454A61K31/573A61P35/00A61P35/02A61P43/00Y02A50/30A61K2300/00
Inventor 克劳迪娅·伊芙·卡塞拉
Owner CELGENE CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com