A single-nozzle multi-source biological 3D printing device and method thereof

Abstract

The invention discloses a single-sprayer multi-source biological 3D (three-dimension) printing device and a method thereof, and belongs to the field of tissue engineering and biological 3D printing. The single-sprayer multi-source biological 3D printing device comprises a motor fixing base, an electric motor, an active gear, a fixing rotary shaft, a turntable joining piece, a sprayer body, a unidirectional connecting valve, a spring sheet, a feeding pipe joint and other structures; the fixing rotary shaft is installed and fixed, the electric motor drives a turntable to rotate through a gear transmission belt; the unidirectional connecting valve on the turntable is clamped and pressed through two spring sheets, a height difference delta h forms between the unidirectional connecting valve and the sprayer body; when the unidirectional connecting valve is rotated to the sprayer body, the sprayer body props up the unidirectional connecting valve, and a steel ball is propped up to connect the sprayer body with the unidirectional connecting valve; the spring sheet is popped up to press the unidirectional connecting valve; meanwhile, biological materials enter through the feeding pipe joint so as to realize the printing process. Through rotating the turntable, the printing material can be switched to print multiple biological materials with a single sprayer. The single-sprayer multi-source biological 3D (three-dimension) printing device is simple and ingenious in structure, reduces cost, and is easy to realize the flexible control; besides, the printing efficiency is greatly improved.

Description

technical field [0001] The invention relates to a biological 3D printing device with a single nozzle and multiple material sources and a method thereof, which are used for printing cells and biological materials, and belong to the field of tissue engineering technology and biological 3D printing. Background technique [0002] For the treatment of damaged large soft tissues and internal organs, human tissue and organ transplantation is an extremely effective treatment method. However, due to the shortage of organ donor sources, immune rejection and other problems, there are insurmountable difficulties in the practical application of organ transplantation. The proposal of tissue engineering has opened up a new way to solve the above problems. Tissue engineering is to attach living cells to biomaterial matrices or prepared scaffolds by a certain method to construct functional tissue substitutes. Then the constructed tissue substitutes are cultured and implanted into the patie...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of complex multi-material and multi-nozzle parallel printing mechanism, large volume, mutual interference of printing nozzles and inflexible control, and provide a single-nozzle multi-material source biological 3D printing with ingenious structure and easy control Apparatus and method thereof

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