Ionic hydrophilic polymer coatings for use in medical devices

Abstract

According to one aspect of the disclosure, medical devices are provided which have a negatively charged surface and a lubricous hydrophilic coating comprising a sulf(on)ated species disposed on the negatively charged surface. In various embodiments, the sulf(on)ated species is ionically crosslinked with itself and with the negatively charged species by a multivalent cationic species. In other aspects, medical devices are provided which have a polymeric surface and a lubricous hydrophilic layer comprising a covalently crosslinked sulf(on)ated species disposed on the surface. Still other aspects of the invention pertain to methods of forming such devices and methods of using such devices.

Description

[0001] Statement of relevant application [0002] This application claims the benefit of U.S. Patent Application Serial No. 61 / 728,919, entitled "Ionic Hydrophilic Polymer Coatings for Medical Devices," filed November 21, 2012, the entire contents of which are incorporated by reference way incorporated into this article. Background technique [0003] A hydrophilic coating is a coating that exhibits strong chemical interactions with water, for example by forming hydrogen bonds with surrounding water molecules. In each case, the hydrophilic coating is ionic, thus further facilitating the interaction with water. Hydrogel materials are capable of readily wetting and often form slippery surfaces when in contact with water. [0004] When used in medical devices such as insertable guidewires and catheters, the low coefficient of friction exhibited by hydrogel coatings can reduce the insertion forces associated with such medical devices, allowing such medical devices to be more eas...

AI Technical Summary

Problems solved by technology

However, medical devices of this type are subject to considerable shear stress during use, which can lead to particle release due to cracking of the coating

In addition, in some devices, particle release occurs due to the release and precipitation of chemicals present within the material forming the device

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